Interaction between polymorphisms in the renin-angiotensin-system and angiotensin-converting enzyme inhibitor or beta-blocker use and the risk of myocardial infarction and stroke

Autor: C M van Duijn, A. Hofman, B.H.Ch. Stricker, J. C. M. Witteman, Olaf H. Klungel, A. de Boer, M.M.B. Breteler, H Schelleman

Publikováno v: Pharmacogenomics Journal, 8(6), 400-407. Nature Publishing Group

This study investigates whether the interaction between angiotensin-converting enzyme (ACE) inhibitors or beta-blockers and the ACE insertion/deletion (I/D) polymorphism or angiotensin receptor II type 1 (AGTR1) 573C/T polymorphism modifies the risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a57b024628d1f8c18331d8b3a984955c
https://doi.org/10.1038/sj.tpj.6500493

Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or β-blockers

Autor: Moygan Yazdanpanah, Monique M.B. Breteler, Cornelia M. van Duijn, A.H. Jan Danser, H Schelleman, Bruno H. Stricker, Jacqueline C.M. Witteman, Olaf H. Klungel, Anthonius de Boer, Albert Hofman

Publikováno v: European Journal of Human Genetics, 15(4), 478-484. Nature Publishing Group

Angiotensinogen is an essential component of the renin-angiotensin system. ACE-inhibitors and beta-blockers both have a direct influence on this system. To investigate whether the association between use of ACE-inhibitors or beta-blockers and the ris

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590149a93f9379c2a822ca0542489dc5
https://doi.org/10.1038/sj.ejhg.5201789

DAT1, DRD4, and DRD5 polymorphisms are not associated with ADHD in Dutch families

Autor: Peter L. Pearson, Emma van der Meulen, Nicole Oteman, H Schelleman, Jan K. Buitelaar, Richard J. Sinke, Steven C. Bakker

Publikováno v: American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 132B, 1, pp. 50-52
American Journal of Medical Genetics. Part B : Neuropsychiatric Genetics, 132B, 50-52

Recent meta-analyses have indicated that the dopamine transporter gene (DAT1) and the dopamine receptor genes D4 (DRD4) and D5 (DRD5) are associated with attention-deficit hyperactivity disorder (ADHD), although single studies frequently failed to sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ec2565c1c740e08c3f489d929f94a6
https://hdl.handle.net/2066/57108

Drug-gene interactions between genetic polymorphisms and antihypertensive therapy

Autor: Anthonius de Boer, Olaf H. Klungel, Cornelia M. van Duijn, Monique W. M. Verschuren, Abraham A. Kroon, Bruno H. Stricker, H Schelleman, Bruce M. Psaty

Publikováno v: Drugs, 64, 1801-1816. Adis

Genetic factors may influence the response to antihypertensive medication. A number of studies have investigated genetic polymorphisms as determinants of cardiovascular response to antihypertensive drug therapy. In most candidate gene studies, no suc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ae3e38af4c858625afc4e19a73d603
https://pubmed.ncbi.nlm.nih.gov/15301563

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