Výsledky vyhledávání

Identification of an immunodominant sequential epitope in glycoprotein G of herpes simplex virus type 2 that is useful for serotype-specific diagnosis

Autor: H S, Marsden, K, MacAulay, J, Murray, I W, Smith

Publikováno v: Journal of medical virology. 56(1)

A series of 67 oligopeptides that spanned the open reading frame of herpes simplex virus type 2 (HSV-2) glycoprotein G (gG2) were synthesized and tested for reactivity with 173 serum specimens collected from 117 individuals. The oligopeptides were ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e861d2faf8ba1fcb8a564faacbe03fa2
https://pubmed.ncbi.nlm.nih.gov/9700637

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The herpes simplex virus type 1 strain 17 open reading frame RL1 encodes a polypeptide of apparent M(r) 37K equivalent to ICP34.5 of herpes simplex virus type 1 strain F

Autor: E. M. McKay, H. S. Marsden, S M Brown, B. McVey, Alasdair Roderick Maclean

Publikováno v: The Journal of general virology. 74

The region between the 'a' sequence and the 5' end of the IE1 gene within the long repeat sequence of the herpes simplex virus (HSV) genome plays an important role in the neurovirulence of both HSV-1 strain F and HSV-1 strain 17. However, there has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9388c706651bc7d4d664b7a0fd7d5667
https://pubmed.ncbi.nlm.nih.gov/8245868

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Production and characterization of monoclonal antibodies to cervine herpesvirus-1

Autor: J R, Lyaku, J A, Sinclair, P F, Nettleton, H S, Marsden

Publikováno v: Veterinary microbiology. 32(3-4)

Fourteen hybridoma cell lines secreting monoclonal antibodies (Mab) to cervine herpesvirus-1 (CerHV-1) produced following the fusion of NSO myeloma cells with splenocytes of BALB/c mice previously immunized with gradient purified CerHV-1 were selecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d33c7372513e94db593ee759802eeb20
https://pubmed.ncbi.nlm.nih.gov/1333671

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Advantages of branched peptides in serodiagnosis. Detection of HIV-specific antibodies and the use of glycine spacers to increase sensitivity

Autor: H S, Marsden, A M, Owsianka, S, Graham, G W, McLean, C A, Robertson, J H, Subak-Sharpe

Publikováno v: Journal of immunological methods. 147(1)

The reactivities of antibodies with branched and monomeric peptides were compared in ELISA assays. We found that lower amounts of antibodies could be detected with branched peptides than with monomeric peptides. This was observed with a monoclonal an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4bf5ecb4f8b082e7f57dae4013c54f70
https://pubmed.ncbi.nlm.nih.gov/1541843

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Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor

Autor: Lindsey Moore, J C Glorioso, Anne Margrete Øyan, Nina Langeland, A Cross, Lars Haarr, H S Marsden

We have previously shown that aminoglycosides such as neomycin and the polyamino acids polylysine and polyarginine selectively inhibit the binding of herpes simplex virus type 1 (HSV-1) to the cellular receptor, whereas HSV-2 infection is unaffected.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830910904f1a525cb34af82f6a81920a
https://europepmc.org/articles/PMC249243/

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Purification of the herpes simplex virus type 1 65-kilodalton DNA-binding protein: properties of the protein and evidence of its association with the virus-encoded DNA polymerase

Autor: M L Gallo, H S Marsden, Deborah S. Parris, M Murphy, D H Jackwood

Publikováno v: Journal of Virology. 62:2874-2883

Using a combination of conventional column chromatography and velocity sedimentation, we have purified the 65-kilodalton DNA-binding protein (65KDBP) encoded by herpes simplex virus (HSV) greater than 625-fold. The HSV type 1 (HSV-1)-encoded DNA poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621d63cfaa444f7225207b118db0e74f
https://doi.org/10.1128/jvi.62.8.2874-2883.1988

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Control of Protein Synthesis in Herpesvirus-infected Cells: Analysis of the Polypeptides Induced by Wild Type and Sixteen Temperature-sensitive Mutants of HSV strain 17

Autor: I. K. Crombie, J. H. Subak-Sharpe, H. S. Marsden

Publikováno v: Journal of General Virology. 31:347-372

Summary The polypeptides induced in cells infected with a Glasgow isolate of HSV-1 (17 syn +) have been characterized by SDS polyacrylamide gel electrophoresis. Study of the kinetics of synthesis in three cell lines has detected a total of 52 polypep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c882b199e22cb7aa8f36ff4fa63974f1
https://doi.org/10.1099/0022-1317-31-3-347

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Identification of the gene encoding the 65-kilodalton DNA-binding protein of herpes simplex virus type 1

Autor: A Cross, H S Marsden, Deborah S. Parris, M Murphy, A Orr, D J McGeoch, M C Frame, L Haarr

Publikováno v: Journal of Virology. 62:818-825

Hybrid arrest of in vitro translation was used to localize the region of the herpes simplex virus type 1 genome encoding the 65-kilodalton DNA-binding protein (65KDBP) to between genome coordinates 0.592 and 0.649. Knowledge of the DNA sequence of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d449168c7bb2af151d925d94cd2454
https://doi.org/10.1128/jvi.62.3.818-825.1988

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Two-dimensional Gel Analysis of HSV Type 1-induced Polypeptides and Glycoprotein Processing

Autor: L. Haarr, H. S. Marsden

Publikováno v: Journal of General Virology. 52:77-92

Two hundred and thirty virus-induced polypeptides have been detected in BHK cells infected with herpes simplex virus type 1 (HSV-1; strain 17) by means of two-dimensional gel electrophoresis. The polypeptides have been characterized by both relative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b67ab377ccef7a4aa1dd7fc47233921
https://doi.org/10.1099/0022-1317-52-1-77

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