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Randomized, Controlled Study of the Safety and Efficacy of Intravenous Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS

Autor: Francoise Kramer, Gary N. Holland, David V. Ives, D W Northfelt, W D Hardy, A E Ruby, Gary L. Simon, Jacob Lalezari, R. J. Stagg, Carol A. Kemper, G F McKinley, M Youle, Richard A. Wolitz, David V. Weinberg, M. Johnson, Baruch D. Kuppermann, R Nelson, H. S. Jaffe, Richard A. Lewis

Publikováno v: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 17:339-344

To assess the effect of intravenous cidofovir on delaying progression of previously treated, relapsing cytomegalovirus (CMV) retinitis, we conducted a randomized, controlled comparison of two maintenance dose levels of cidofovir. One hundred and fift

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d624e098cc2515cff20d9dd19a469b
https://doi.org/10.1097/00042560-199804010-00008

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Anti‐Human Immunodeficiency Virus (HIV) Activity, Safety, and Pharmacokinetics of Adefovir Dipivoxil (9‐[2‐(bis‐pivaloyloxymethyl)‐phosphonylmethoxyethyl]adenine) in HIV‐Infected Patients

Autor: Kenneth C. Cundy, D. Ebeling, Paul S. Lietman, J. Toole, Craig W. Hendrix, H. S. Jaffe, Patricia Barditch-Crovo

Publikováno v: The Journal of Infectious Diseases. 176:406-413

A randomized, double-blind, placebo-controlled, dose-escalation study of adefovir dipivoxil, an oral prodrug of adefovir, was conducted in 36 human immunodeficiency virus (HIV)-infected subjects to evaluate its anti-HIV activity, safety, and pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abe05a665469a2ff9b295477ac2fccc
https://doi.org/10.1086/514057

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Cidofovir, a New Agent with Potent Anti-Herpesvirus Activity

Autor: Michael J. M. Hitchcock, John C. Martin, R. J. Stagg, H. S. Jaffe

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:115-127

Cidofovir is a potent, broad spectrum antiviral agent with activity in vitro and in vivo against cytomegalovirus and other members of the herpesvirus family, as well as certain other DNA viruses. After uptake into cells it is converted enzymatically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b979c2782dc6a1cabed63bf53cae2a82
https://doi.org/10.1177/095632029600700301

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Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

Autor: Ann C. Collier, Patricia Barditch-Crovo, Kenneth C. Cundy, D. Ebeling, R E Walker, H. S. Jaffe, J. Toole

Publikováno v: Antimicrobial Agents and Chemotherapy. 39:2401-2405

The pharmacokinetics and bioavailability of adefovir [9-[2-(phosphonomethoxy)ethyl]adenine] were examined at two dose levels in three phase I/II studies in 28 human immunodeficiency type 1-infected patients. The concentrations of adefovir in serum fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d55586ad32ff5255293930c7893e0cc
https://doi.org/10.1128/aac.39.11.2401

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(S)-1-[3-Hydroxy-2-(Phosphonylmethoxy)propyl]cytosine (Cidofovir): Results of a Phase I/II Study of a Novel Antiviral Nucleotide Analogue

Autor: J. Hannigan, J. C. Martin, W L Drew, P. E. Fisher, K. Cundy, Christopher J. James, J. Flaherty, E. Glutzer, H. S. Jaffe, D. Miner, Jacob Lalezari

Publikováno v: Journal of Infectious Diseases. 171:788-796

Cidofovir, (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine, is a novel antiviral nucleotide analogue with potent in vitro and in vivo activity against cytomegalovirus (CMV) and other herpesviruses. Thirty-one human immunodeficiency virus-seropo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b90245c8005c307ef8e5d76d1c47bf2
https://doi.org/10.1093/infdis/171.4.788

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Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruria

Autor: H S Jaffe, P. E. Fisher, Barbara F. Baird, J F Manischewitz, Robert E. Walker, Richard T. Davey, Judith Falloon, J A Kovacs, Spooner Km, Michael A. Polis

Publikováno v: Antimicrobial Agents and Chemotherapy. 39:882-886

Cidofovir (HPMPC; (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine) is a nucleotide analog with activity against human cytomegalovirus (CMV). A phase I/II dose escalation trial was conducted with asymptomatic human immunodeficiency virus (HIV)-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f061ba13487a6af5552a2aa57498988
https://doi.org/10.1128/aac.39.4.882

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Prolonged recombinant interferon-gamma therapy in chronic granulomatous disease: evidence against enhanced neutrophil oxidase activity

Autor: R C, Woodman, R W, Erickson, J, Rae, H S, Jaffe, J T, Curnutte

Publikováno v: Blood. 79:1558-1562

Recombinant interferon-gamma (rIFN-gamma) therapy has become an effective form of prophylaxis for patients with chronic granulomatous disease (CGD). Preliminary studies with CGD suggested that rIFN-gamma treatment enhanced phagocyte oxidase activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8421dc8bbc327131e45fd43e95203e7f
https://doi.org/10.1182/blood.v79.6.1558.bloodjournal7961558

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Recombinant Human Interferon- as Adjunct Therapy for Aspergillus Infection in a Patient with Chronic Granulomatous Disease

Autor: Howard M. Lederman, Jan Bernhisel-Broadbent, Edwaldo E. Camargo, H. S. Jaffe

Publikováno v: Journal of Infectious Diseases. 163:908-911

The hallmark of chronic granulomatous disease (CGD) is defective killing of ingested microorganisms by phagocytic cells. Invasive aspergillosis in CGD patients is particularly virulent and has a mortality rate of approximately 50%. A patient with aut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bad8d3c75505e7af60a773c11c83308
https://doi.org/10.1093/infdis/163.4.908

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Human recombinant interferon gamma enhances neonatal polymorphonuclear leukocyte activation and movement, and increases free intracellular calcium

Autor: Nancy H. Augustine, H S Jaffe, Harry R. Hill

Publikováno v: The Journal of Experimental Medicine

In previous studies, we have reported that after chemotactic factor stimulation, PMNs from neonates fail to undergo certain critical activation steps. Furthermore, the concentration of free intracellular calcium reached is significantly below that of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90c22b7c834bda0d9fa7a34a67c5f01
https://doi.org/10.1084/jem.173.3.767

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Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infection

Autor: J. F. Rooney, Michel Bossens, Robert Snoeck, H. S. Jaffe, B. Delaere, E. De Clercq, M. S. Wulfsohn, Dominique Parent, Jean Christophe Noël, M. Van Ranst, H. Degreef

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 33(5)

Genital condylomata acuminata are nonmalignant human papillomavirus (HPV)-induced tumors in which HPV types 6 and 11 are most commonly found. Usual treatments for condylomata acuminata are nonspecific and are based on the destruction or removal of in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c6b13a95f46d43ac0beb6a0dd595b2
https://pubmed.ncbi.nlm.nih.gov/11477525

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