Výsledky vyhledávání - "H S Auerbach"

Molecular basis of complement C3 deficiency in guinea pigs

Autor: H S Auerbach, R Burger, Harvey R. Colten, A Dodds

Publikováno v: Journal of Clinical Investigation. 86:96-106

In experiments to ascertain the biochemical basis of a genetically determined deficiency of the third component of complement (C3) in guinea pigs, we found that C3-deficient liver and peritoneal macrophages contain C3 messenger RNA of normal size (ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbbf7ff0c3ab60e174aef2e3d319826
https://doi.org/10.1172/jci114721

Zobrazit plný text záznamu

Tissue-specific pretranslational regulation of complement production in human mononuclear phagocytes

Autor: F S Cole, H S Auerbach, G Goldberger, H R Colten

Publikováno v: The Journal of Immunology. 134:2610-2616

The net production of the complement protein C2, C4, and factor B differ among mononuclear phagocytes from peripheral blood and different tissues in experimental animals and in humans. To examine the mechanisms that regulate these differences in huma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4d0d28f692f1a1eede6a8052910d08e
https://doi.org/10.4049/jimmunol.134.4.2610

Zobrazit plný text záznamu

Isolation of guinea pig macrophages bearing surface C4 by fluorescence-activated cell sorting: correlation between surface C4 antigen and C4 protein secretion

Autor: H S Auerbach, M E Lalande, S Latt, H R Colten

Publikováno v: The Journal of Immunology. 131:2420-2426

Studies of complement (C) secretion by single cells indicate that only a subset of a guinea pig macrophage population is capable of secreting the second (C2) and fourth (C4) components of C. Moreover, cell-surface bound C4 antigen is also found on a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1df4752c4f412ffa5da34fe80f75f9cd
https://doi.org/10.4049/jimmunol.131.5.2420

Zobrazit plný text záznamu

Biosynthesis of a structurally abnormal C2 complement protein by macrophages from C2-deficient guinea pigs

Autor: G Goldberger, F S Cole, L P Einstein, H S Auerbach, D Bitter-Suermann, H R Colten

Publikováno v: The Journal of Immunology. 129:2061-2065

In order to characterize a genetic deficiency of C2 in guinea pigs, production of C2 by peritoneal macrophage cultures derived from four normal, four heterozygous deficient, and four homozygous deficient animals was measured functionally and immunoch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc6eb67edd3d6275a733b70d74f59679
https://doi.org/10.4049/jimmunol.129.5.2061

Zobrazit plný text záznamu

The α1-Antitrypsin Gene Is Expressed in a Human Intestinal Epithelial Cell Line

Autor: H S Auerbach, H S Winter, K De Schryver-Kecskemeti, David H. Perlmutter, David H. Alpers, J D Daniels

Publikováno v: Journal of Biological Chemistry. 264:9485-9490

alpha 1-Antitrypsin (alpha 1-AT) is considered a typical plasma protein and a prototype of the serine proteinase inhibitor (serpin) family. It is synthesized in hepatocytes and, to a lesser extent, in macrophages. In this study we show that the alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d1a74cfd38d75660739ee03f1d6d4c6
https://doi.org/10.1016/s0021-9258(18)60557-5

Zobrazit plný text záznamu

C1s-induced vascular permeability in C2-deficient guinea pigs

Autor: C J Strang, H S Auerbach, F S Rosen

Publikováno v: The Journal of Immunology. 137:631-635

Normal guinea pigs that have been intradermally injected with C1s exhibit increased vascular permeability at the injection site. Guinea pigs that are genetically deficient in complement component C2 do not exhibit increased vascular permeability when

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc3099dae7ef2e2339d1d7a3960b8bf5
https://doi.org/10.4049/jimmunol.137.2.631

Zobrazit plný text záznamu

Macrophage maturation: differences in complement secretion by marrow, monocyte, and tissue macrophages detected with an improved hemolytic plaque assay

Autor: S E Alpert, H S Auerbach, F S Cole, H R Colten

Publikováno v: The Journal of Immunology. 130:102-107

In order to examine one function of mononuclear phagocytes during maturation from bone marrow precursors to tissue macrophages, an improved hemolytic plaque assay for the detection of synthesis of the second (C2) and fourth (C4) components of C by si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a311e4884bd477de1703a0e2fa274cb9
https://doi.org/10.4049/jimmunol.130.1.102

Zobrazit plný text záznamu

The Molecular Basis for Genetic Deficiency of the Second Component of Human Complement

Autor: H R Colten, P Kilbridge, T Lint, F S Cole, H S Auerbach, H J Zeitz, A S Whitehead

Publikováno v: New England Journal of Medicine. 313:11-16

Genetic deficiency of the second component of complement (C2) is the most common complement-deficiency state among Western Europeans and is frequently associated with autoimmune diseases. To examine the molecular basis of this deficiency, we establis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef23722ef2097c82a9296137c3b509d
https://doi.org/10.1056/nejm198507043130103

Zobrazit plný text záznamu