Zobrazeno 1 - 10
of 52
pro vyhledávání: '"H S, Luthra"'
Publikováno v:
The Journal of Immunology. 156:2761-2768
A series of 101 peptides each 20 amino acids in length (10-residue overlap) spanning the helical portion of the mature alpha-chain of human type II collagen (CII) was synthesized. DBA/1 (H-2q) mice were immunized with individual peptides, and drainin
Oral administration of an immunodominant human collagen peptide modulates collagen-induced arthritis
Publikováno v:
The Journal of Immunology. 155:3653-3659
Human type II collagen (HuCII) may be one of the autoantigens involved in human rheumatoid arthritis (RA). By using over-lapping peptides, we have previously described an immunodominant region (HuCII.250-270) on HuCII. In the present study, this 21-m
Autor:
M M Griffiths, G H Nabozny, J Hanson, D S Harper, S McCall, K G Moder, G W Cannon, H S Luthra, C S David
Publikováno v:
The Journal of Immunology. 153:2758-2768
B10.Ek alpha transgenic mice were mated with H2-E B10.Q and SWR mice. F1 and F1 x parental strain backcross progeny were tested for arthritis and autoimmune reactivity to mouse type II collagen (MII) after immunization with bovine, chick, deer, or hu
Publikováno v:
The Journal of Immunology. 147:1189-1193
The role of T cell-mediated and humoral immunity to type II collagen has been well documented in collagen-induced arthritis (CIA). Previous work from our laboratory has indicated that genomic deletions of TCR V beta genes may play a role in CIA resis
Is rheumatoid arthritis care more costly when provided by rheumatologists compared with generalists?
Publikováno v:
Arthritis and rheumatism. 44(7)
Controversy surrounds the cost-effectiveness of rheumatologist care compared with generalist care for patients with rheumatoid arthritis (RA). Rheumatologists can provide 2 distinct types of care for RA patients: primary care and specialist care. We
Autor:
D M, Menke, H, Griesser, K G, Moder, A, Tefferi, H S, Luthra, M D, Cohen, G, Colon-Otero, R V, Lloyd
Publikováno v:
American journal of clinical pathology. 113(2)
Cell cycle dysregulation as measured by p53 protein expression and latent Epstein-Barr (EBV) infection are important in the pathogenesis of lymphoma, particularly in immunosuppressed patients. Although latent EBV commonly is detected in lymphomas ari
Publikováno v:
Tissue Antigens. 17:442-443
Relapsing polychondritis is a systemic disease of unknown cause in which various inflammatory reactions recur in the cartilage structures of the ears, nose, and trachea (Kaye & Sones 1964). Although the cause of this disease is unknown, several immun
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(9)
We have generated transgenic (tg) mice expressing HLA-DQ8alphabeta (DQA1*0301/DQB*0302) or HLA-DQ6alphabeta (DQA1*0103/DQB1*0601) molecules lacking endogenous murine class II expression (A beta0) to investigate the ability of these HLA class II to pr
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(1)
Although association of HLA-B27 with human spondyloarthropathies has been known for several years, its role in disease pathogenesis is not understood. Recently, a few investigators have proposed that presentation of B27-derived peptides by MHC class
Autor:
M A, Gonzalez-Gay, E, Zanelli, S D, Khare, C J, Krco, M M, Griffiths, H S, Luthra, C S, David
Publikováno v:
Immunogenetics. 44(5)
Collagen-induced arthritis (CIA) is an animal model of auto-immune inflammatory polyarthritis which has features similar to rheumatoid arthritis (RA). Much like RA, susceptibility to mouse CIA is influenced by the major histocompatibility complex (MH