Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors

Autor: Daniël Verhoef, Koen M. Visscher, C. Ruben Vosmeer, Ka Lei Cheung, Pieter H. Reitsma, Daan P. Geerke, Mettine H. A. Bos

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)

A major drawback in the clinical use of the oral anticoagulants that directly inhibit factor Xa in order to prevent blood clot formation is the potential for life threatening bleeding events. Here the authors describe factor Xa variants that are refr

Externí odkaz: https://doaj.org/article/b141be2853c5434db46bb976a6a0ac12

SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

Autor: Marjon H. Cnossen, Iris van Moort, Simone H. Reitsma, Moniek P.M. de Maat, Roger E.G. Schutgens, Rolf T. Urbanus, Hester F. Lingsma, Ron A.A. Mathot, Samantha C. Gouw, Karina Meijer, Annelien L. Bredenoord, Rieke van der Graaf, Karin Fijnvandraat, Alexander B. Meijer, Emile van den Akker, Ruben Bierings, Jeroen C.J. Eikenboom, Maartje van den Biggelaar, Masja de Haas, Jan Voorberg, Frank W.G. Leebeek, Ryanne A. Arisz, Minka Zivkovic, E. Shannon van Hoorn, Laura H. Bukkems, Tine M.C.H.J. Goedhart, Lorenzo G.R. Romano, Wala Al Arashi, Michael E. Cloesmeijer, Alexander Janssen, Martijn R. Brands, Lieke Baas, Jessica del Castillo Alferez, Huan Zhang, Sebastiaan N.J. Laan, Johan Boender, Johanna G. van der Bom, Mettine H.A. Bos, Lex Burdorf, Michiel Coppens, Mariette Driessens, Kathelijne F. Fischer, Lotte Haverman, Jan A. Hazelzet, Elise J. Huisman, Natalie Jansen, Sean de Jong, Marieke Kruip, Nikki van Leeuwen, Felix van der Meer, Stephan Meijer, Hans Kristian Ploos van Amstel, Suzanne Polinder, Saskia E.M. Schols, Guus Wijfjes, Kees Kluft, Waander L. van Heerde, Geertje Goedhart, Carin Uyl, Jasmijn Timp, Anke Stekelenburg, Floor Moenen, Paula Ypma, Laurens Nieuwenhuizen, Arnoud Plat

Publikováno v: Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. Wiley
Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. Wiley-Blackwell
Journal of thrombosis and haemostasis, 20(9), 2001-2011. Wiley-Blackwell
Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. WILEY
Journal of Thrombosis and Haemostasis, 20(9), 2001-2011. Wiley-Blackwell Publishing Ltd
SYMPHONY consortium 2022, ' SYMPHONY consortium : Orchestrating personalized treatment for patients with bleeding disorders ', Journal of Thrombosis and Haemostasis, vol. 20, no. 9, pp. 2001-2011 . https://doi.org/10.1111/jth.15778

Background: Treatment choices for individual patients with an inborn bleeding disorder are increasingly challenging due to increasing options and rising costs for society. We have initiated an integrated interdisciplinary national research program. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f106600596b9764406a2984249fa8169
https://hdl.handle.net/1887/3494538

Clinical profile of patients with adult-onset eosinophilic asthma

Autor: Jantina C. de Groot, Huib Storm, Marijke Amelink, Selma B. de Nijs, Edwin Eichhorn, Bennie H. Reitsma, Elisabeth H.D. Bel, Anneke ten Brinke

Publikováno v: ERJ Open Research, Vol 2, Iss 2 (2016)

Adult-onset eosinophilic asthma is increasingly recognised as a severe and difficult-to-treat subtype of asthma. In clinical practice, early recognition of patients with this asthma subtype is important because it may have treatment implications. The

Externí odkaz: https://doaj.org/article/b5b5f8f52f99459d8899d1b63b7f0658

Changes in Dietary Fat Content Rapidly Alters the Mouse Plasma Coagulation Profile without Affecting Relative Transcript Levels of Coagulation Factors.

Autor: Audrey C A Cleuren, Vicky T Blankevoort, Janna A van Diepen, Daniël Verhoef, Peter J Voshol, Pieter H Reitsma, Bart J M van Vlijmen

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0131859 (2015)

Obesity is associated with a hypercoagulable state and increased risk for thrombotic cardiovascular events.Establish the onset and reversibility of the hypercoagulable state during the development and regression of nutritionally-induced obesity in mi

Externí odkaz: https://doaj.org/article/a06c9576e6704ba9ba6a1579c9ac5cc9

Single nucleotide variants in the protein C pathway and mortality in dialysis patients.

Autor: Gürbey Ocak, Christiane Drechsler, Carla Y Vossen, Hans L Vos, Frits R Rosendaal, Pieter H Reitsma, Michael M Hoffmann, Winfried März, Willem H Ouwehand, Raymond T Krediet, Elisabeth W Boeschoten, Friedo W Dekker, Christoph Wanner, Marion Verduijn

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e97251 (2014)

The protein C pathway plays an important role in the maintenance of endothelial barrier function and in the inflammatory and coagulant processes that are characteristic of patients on dialysis. We investigated whether common single nucleotide variant

Externí odkaz: https://doaj.org/article/e4e2071c45534a77a476402036bd1f81