Zobrazeno 1 - 10
of 17
pro vyhledávání: '"H R Sagara Wijeratne"'
Autor:
Byungwook Kim, Luke Child Dabin, Mason Douglas Tate, Hande Karahan, Ahmad Daniel Sharify, Dominic J. Acri, Md Mamun Al-Amin, Stéphanie Philtjens, Daniel Curtis Smith, H. R. Sagara Wijeratne, Jung Hyun Park, Mathias Jucker, Jungsu Kim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract SPI1 was recently reported as a genetic risk factor for Alzheimer’s disease (AD) in large-scale genome-wide association studies. However, it is unknown whether SPI1 should be downregulated or increased to have therapeutic benefits. To inve
Externí odkaz:
https://doaj.org/article/e22ff5166e4e49748b9eeaf45df4118e
Autor:
Daniel C. Smith, Hande Karahan, H. R. Sagara Wijeratne, Mamun Al-Amin, Brianne McCord, Younghye Moon, Jungsu Kim
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) genetics studies have identified a coding variant within ABI3 gene that increases the risk of developing AD. Recently, we demonstrated that deletion of the Abi3 gene locus dramatically exacerbates AD neuropathology in a tra
Externí odkaz:
https://doaj.org/article/4c9d09bed26248b2be1b1fe6387aba95
Autor:
Tatiana Popovitchenko, Yongkyu Park, Nicholas F. Page, Xiaobing Luo, Zeljka Krsnik, Yuan Liu, Iva Salamon, Jessica D. Stephenson, Matthew L. Kraushar, Nicole L. Volk, Sejal M. Patel, H. R. Sagara Wijeratne, Diana Li, Kandarp S. Suthar, Aaron Wach, Miao Sun, Sebastian J. Arnold, Wado Akamatsu, Hideyuki Okano, Luc Paillard, Huaye Zhang, Steven Buyske, Ivica Kostovic, Silvia De Rubeis, Ronald P. Hart, Mladen-Roko Rasin
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Translational regulation of isoforms in the developing nervous system is not well understood. Here, the authors report translational de-repression of RNA binding protein isoforms at their 5′UTRs in the neocortex and show the neurodevelopmental risk
Externí odkaz:
https://doaj.org/article/26ec0393d8414ff985171a47ea4a1728
Autor:
Nicole L. Volk, Ronald P. Hart, Xiaobing Luo, Yongkyu Park, Nicholas F. Page, Iva Salamon, Huaye Zhang, Yuan Liu, Sejal M. Patel, Sebastian J. Arnold, Mladen-Roko Rasin, Jessica D. Stephenson, H. R. Sagara Wijeratne, Kandarp S. Suthar, Silvia De Rubeis, Wado Akamatsu, Hideyuki Okano, Zeljka Krsnik, Miao Sun, Tatiana Popovitchenko, Diana Li, Aaron Wach, Ivica Kostović, Matthew L. Kraushar, Luc Paillard, Steven Buyske
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1674. ⟨10.1038/s41467-020-15412-8⟩
Nature Communications, 2020, 11 (1), pp.1674. ⟨10.1038/s41467-020-15412-8⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.1674. ⟨10.1038/s41467-020-15412-8⟩
Nature Communications, 2020, 11 (1), pp.1674. ⟨10.1038/s41467-020-15412-8⟩
Neurodevelopment requires precise regulation of gene expression, including post-transcriptional regulatory events such as alternative splicing and mRNA translation. However, translational regulation of specific isoforms during neurodevelopment and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9feab16cc46e4785cf2ff5b0b3dcff59
http://link.springer.com/article/10.1038/s41467-020-15412-8
http://link.springer.com/article/10.1038/s41467-020-15412-8
Autor:
Brady K. Atwood, Yuxin Li, Gonzalo Viana Di Prisco, Mamun Al-Amin, Junmin Peng, H. R. Sagara Wijeratne, Shaoyou Chu, Daniel C. Smith, Byung-Wook Kim, Adrian L. Oblak, Hande Karahan, Taylor Pennington, Brianne McCord, Jungsu Kim, Peter Bor-Chian Lin, Luke C. Dabin
Publikováno v:
Science Advances
Description
A cytoskeleton-associated protein regulates microglial function and affects Alzheimer’s disease phenotypes.
Recently, large-scale human genetics studies identified a rare coding variant in the ABI3 gene that is associated with
A cytoskeleton-associated protein regulates microglial function and affects Alzheimer’s disease phenotypes.
Recently, large-scale human genetics studies identified a rare coding variant in the ABI3 gene that is associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac23eb34d3d9a5303a2cf8722fcaa31
https://doi.org/10.1126/sciadv.abe3954
https://doi.org/10.1126/sciadv.abe3954
Autor:
Aruna B. Wijeratne, Amber L. Mosley, Edward Simpson, Jonah Z. Vilseck, Jose F. Victorino, H. R. Sagara Wijeratne, Guihong D. Qi, Sarah A. Peck Justice, Monica P. Barron
Publikováno v:
J Biol Chem
Temperature-sensitive (TS) missense mutants have been foundational for characterization of essential gene function. However, an unbiased approach for analysis of biochemical and biophysical changes in TS missense mutants within the context of their f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a5ec9c9135de9f846ed7af6a48fc4be
https://pubmed.ncbi.nlm.nih.gov/32878984
https://pubmed.ncbi.nlm.nih.gov/32878984
Autor:
Shelton S. Bradrick, H. R. Sagara Wijeratne, Rafael K. Campos, Mariano A. Garcia-Blanco, Premal Shah
Publikováno v:
Nucleic Acids Research
Dengue virus (DENV) and other mosquito-borne flaviviruses are highly dependent on the ribosomal stalk proteins, RPLP1 and RPLP2 (RPLP1/2), for efficient infection. Here, we show that RPLP1/2 function to relieve ribosome pausing within the DENV envelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106b35fa1bcb864787e18520a49ec80d
Autor:
Kathryn E. Hamilton, Lauren Simon, H. R. Sagara Wijeratne, Shun Liang, Stefanie Marti, David Lee, Fernando Cid Samper, Sarah F. Andres, Priya Chatterji, Louis Parham, Premal Shah, Gian Gaetano Tartaglia, Veronique Giroux, Emma Lundsmith, Gary D. Wu, Lillian Chau, Benjamin J. Wilkins, Kelly A. Whelan, Patrick A. Williams, Rei Mizuno
Publikováno v:
EMBO Rep
RNA binding proteins, including IMP1/IGF2BP1, are essential regulators of intestinal development and cancer. Imp1 hypomorphic mice exhibit gastrointestinal growth defects, yet the specific role for IMP1 in colon epithelial repair is unclear. Our prio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6927d39f6f7d79d1f61f4ec667da68
https://europepmc.org/articles/PMC6549032/
https://europepmc.org/articles/PMC6549032/
Autor:
H R Sagara Wijeratne, Scott A Goldberg, Christopher G Strother, Kevin Munjal, Avital Porat, Nadine Q Lim, Greisy Sanchez
Publikováno v:
Prehospital Emergency Care. 21:14-17
Patient handoff occurs when responsibility for patient diagnosis, treatment, or ongoing care is transferred from one healthcare professional to another. Patient handoff is an integral component of quality patient care and is increasingly identified a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b046c006321185e3008fbc2ceaaf486
https://doi.org/10.1080/10903127.2016.1194930
https://doi.org/10.1080/10903127.2016.1194930
Autor:
Priya Chatterji, Shun Liang, Premal Shah, Kathryn E. Hamilton, Anil K. Rustgi, Philip Hicks, Christopher J. Lengner, Amanda T. Mah, Jason R. Pitarresi, H. R. Sagara Wijeratne, Laurianne Van Landeghem, Andres J. Klein-Szanto, Brian D. Gregory, Lauren Simon, Sarah F. Andres, Blair B. Madison, Shawn W. Foley, Rei Mizuno
RNA-binding proteins (RBPs) are expressed broadly during both development and malignant transformation, yet their mechanistic roles in epithelial homeostasis or as drivers of tumor initiation and progression are incompletely understood. Here we descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55c9891451436aca7a5c710d79a14e7b
https://europepmc.org/articles/PMC6075153/
https://europepmc.org/articles/PMC6075153/