Zobrazeno 1 - 10
of 42
pro vyhledávání: '"H R Ha"'
Autor:
Simon Hebeisen, Stephan Krähenbühl, D Konrad, H R Ha, Katri Maria Waldhauser, Daniel Bur, Karin Brecht
Publikováno v:
British Journal of Pharmacology. 155:585-595
Background and purpose: Amiodarone (2-n-butyl-3-[3,5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran, B2-O-CH2CH2-N-diethyl) is an effective class III antiarrhythmic drug demonstrating potentially life-threatening organ toxicity. The principal aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b2a15b353b56bc06205c8a00d17d4d
https://doi.org/10.1038/bjp.2008.287
https://doi.org/10.1038/bjp.2008.287
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0290733 (2023)
BackgroundOlder adults frequently attend the Emergency Department (ED) with poorly defined symptoms, often called nonspecific complaints (NSC). NSC such as 'weakness' and 'not feeling well', often lead to an extensive differential diagnosis. Patients
Externí odkaz:
https://doaj.org/article/5b1a59b9f28f4b7ab0909bd9fc7a0d98
Publikováno v:
Xenobiotica. 31:239-248
1. Amiodarone (AMI) is a potent anti-arrhythmic drug and mono-N-desethylamiodarone (MDEA) is its only known metabolite. It was found recently that in rabbit liver microsomes MDEA was biotransformed to n-3-hydroxybutyl-MDEA (3OH-MDEA). 2. In liver mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49f314e718e3ba520efb72034cf2f90
https://doi.org/10.1080/00498250110046442
https://doi.org/10.1080/00498250110046442
Publikováno v:
Journal of Liquid Chromatography. 18:2243-2255
An isocratic, rapid, sensitive and selective reversed phase high-performance liquid chromatographic (HPLC) assay with ultraviolet detection has been used to quantify the in vitro nimodipine metabolism in rat liver microsomes. (±) Nimodipine and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d0aea50390884067004d19cc3d09299
https://doi.org/10.1080/10826079508010268
https://doi.org/10.1080/10826079508010268
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Publikováno v:
British Journal of Clinical Pharmacology. 31:279-286
1. Population pharmacokinetic parameters of quinidine were determined based on 260 serum drug concentration measurements in 60 patients treated for arrhythmias with quinidine sulphate or quinidine bisulphate (Kinidin duriles) orally. 2. Quinidine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a48400811c1fa1e0e4ece90ace685b3
https://doi.org/10.1111/j.1365-2125.1991.tb05531.x
https://doi.org/10.1111/j.1365-2125.1991.tb05531.x
Publikováno v:
European Journal of Clinical Pharmacology. 38:509-513
The pharmacokinetics of oral and i.v. propafenone and its major metabolites have been investigated in 8 healthy subjects. The total body clearance of propafenone was 963 ml/min, the terminal half-life 198 min and its absolute bioavailability was 15.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4007f9c7571619783648c88595109c
https://doi.org/10.1007/bf02336693
https://doi.org/10.1007/bf02336693
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 757(2)
Amiodarone (AMI) is a potent antiarrhythmic drug. In vivo and in vitro, AMI is biotransformed to mono-N-desethylamiodarone (MDEA). Recently, it was observed that MDEA was further hydroxylated to n-3'-hydroxybutyl-MDEA (3'OH-MDEA). The performance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3918390d194482718dd8c7828f5421ca
https://pubmed.ncbi.nlm.nih.gov/11417876
https://pubmed.ncbi.nlm.nih.gov/11417876
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(2)
Amiodarone (AMI) is a potent antiarrhythmic drug, but its metabolism has not yet been fully documented. Mono-N-desethylamiodarone (MDEA) is its only known metabolite. Our preliminary investigations using rabbit liver microsomes had shown that in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c9305e4b5274bdb379f97ad90bdc297
https://pubmed.ncbi.nlm.nih.gov/11159805
https://pubmed.ncbi.nlm.nih.gov/11159805