Výsledky vyhledávání - "H R, Gralnick"

Platelet adhesion to collagen types I through VIII under conditions of stasis and flow is mediated by GPIa/IIa (alpha 2 beta 1-integrin)

Autor: E U, Saelman, H K, Nieuwenhuis, K M, Hese, P G, de Groot, H F, Heijnen, E H, Sage, S, Williams, L, McKeown, H R, Gralnick, J J, Sixma

Publikováno v: Blood. 83:1244-1250

Platelet adhesion to fibrillar collagens (types I, II, III, and V) and nonfibrillar collagens (types IV, VI, VII, and VIII) was investigated in the presence of physiologic concentrations of divalent cations under conditions of stasis and flow. Under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c67fbaff5b8c6bd312d3073cac56071
https://doi.org/10.1182/blood.v83.5.1244.bloodjournal8351244

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Platelet adhesion to cyanogen-bromide fragments of collagen alpha 1(I) under flow conditions

Autor: E U, Saelman, L F, Horton, M J, Barnes, H R, Gralnick, K M, Hese, H K, Nieuwenhuis, P G, de Groot, J J, Sixma

Publikováno v: Blood. 82:3029-3033

The aim of this investigation was to identify domains of collagen type I that can support platelet adhesion under flow conditions. Four cyanogen bromide (CB) fragments composing 87% of the collagen alpha 1(I)-chain were studied under static and flow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc59fc7ecdf40a3e8fb32e20f76a562b
https://doi.org/10.1182/blood.v82.10.3029.bloodjournal82103029

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Platelet adhesion to cyanogen-bromide fragments of collagen alpha 1(I) under flow conditions

Autor: L. F. Horton, K. M. Hese, H. K. Nieuwenhuis, E. U. M. Saelman, H. R. Gralnick, J. J. Sixma, P. G. De Groot, Michael J. Barnes

Publikováno v: Blood. 82:3029-3033

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44f37a6833d32d5a6f3c1972fc7171ff
https://doi.org/10.1182/blood.v82.10.3029.3029

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Gamma-interferon modulates von Willebrand factor release by cultured human endothelial cells

Autor: S H, Tannenbaum, H R, Gralnick

Publikováno v: Blood. 75:2177-2184

Endothelial cells (EC) synthesize and secrete von Willebrand factor (vWF), a multimeric glycoprotein required for normal hemostasis. Within human endothelial cells, vWF multimers of extremely high molecular weight are stored in rod-shaped organelles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d5fe46d2ca3a04e6db367387850ab8
https://doi.org/10.1182/blood.v75.11.2177.bloodjournal75112177

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Platelet von Willebrand factor in Hermansky-Pudlak syndrome

Autor: L P, McKeown, K E, Hansmann, O, Wilson, W, Gahl, H R, Gralnick, K E, Rosenfeld, S J, Rosenfeld, M K, Horne, M E, Rick

Publikováno v: American journal of hematology. 59(2)

The Hermansky-Pudlak Syndrome (HPS) is an autosomal recessive inherited disorder characterized by oculocutaneous albinism, tissue accumulation of ceroid pigment, and a mild to moderate bleeding diathesis attributed to storage-pool deficient (SPD) pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50e3c5a3b4888ceb13d603abada54c58
https://pubmed.ncbi.nlm.nih.gov/9766795

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Fibrinolytic and coagulant responses to regional limb perfusions of tumor necrosis factor, interferon-gamma, and/or melphalan

Autor: P, Merryman, S H, Tannenbaum, H R, Gralnick, K, Yu, W S, Arnold, H R, Alexander, D, Fraker, M K, Horne

Publikováno v: Thrombosis and haemostasis. 77(1)

Regional limb perfusion with antineoplastic agents stresses the local vasculature in a variety of ways. However, by monitoring the perfusates from limbs treated with melphalan alone or with melphalan plus tumor necrosis factor (TNF) and interferon-ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9653035e74cd2c20514b58d48e759e66
https://pubmed.ncbi.nlm.nih.gov/9031449

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1-Desamino-8-arginine-vasopressin corrects the hemostatic defects in type 2B von Willebrand's disease

Autor: L P, McKeown, G, Connaghan, O, Wilson, K, Hansmann, P, Merryman, H R, Gralnick

Publikováno v: American journal of hematology. 51(2)

DDAVP is effective treatment in most types of von Willebrand's disease; however, in type 2B von Willebrand's disease the use of DDAVP has been contraindicated due to DDAVP-induced thrombocytopenia. Several reports have confirmed the thrombocytopenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7455c3f989b7af8c15456d1ba5d1f3bf
https://pubmed.ncbi.nlm.nih.gov/8579058

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Heparin enhances endothelial cell von Willebrand factor content by growth factor dependent mechanisms

Autor: S H, Tannenbaum, E S, Chao, H R, Gralnick

Publikováno v: Thrombosis and haemostasis. 72(5)

Von Willebrand factor (vWf), a multimeric adhesive glycoprotein synthesized, stored, and secreted in megakaryocytes and endothelial cells, is normally found in plasma, platelets and subendothelium. While many substances mediate the release of vWf fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ff658ec3dd5601ed9a9b6467f2f03320
https://pubmed.ncbi.nlm.nih.gov/7900084

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