Zobrazeno 1 - 10
of 95
pro vyhledávání: '"H R, Bourne"'
Publikováno v:
Journal of Biological Chemistry. 265:2671-2676
The biochemical properties of three stimulatory guanine nucleotide-binding protein (G-protein) alpha subunits, the large and small forms of Gs, Gs-l (52 kDa) and Gs-s (45 kDa), and the olfactory specific G-protein, Golf, have been compared. Complemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e337de3273bfd26a750e642333ddfea
https://doi.org/10.1016/s0021-9258(19)39853-9
https://doi.org/10.1016/s0021-9258(19)39853-9
Autor:
H R, Bourne
Publikováno v:
Ernst Schering Foundation symposium proceedings. (2)
From the point of view of a participant observer, I tell the discovery stories of trimeric G-proteins and GPCRs, beginning in the 1970s. As in most such stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe02ae4321c810e2643e206fe8c6e839
https://pubmed.ncbi.nlm.nih.gov/17703575
https://pubmed.ncbi.nlm.nih.gov/17703575
Autor:
H. R. Bourne
Publikováno v:
Ernst Schering Foundation Symposium Proceedings ISBN: 9783540489818
From the point of view of a participant observer, I tell the discovery stories of trimeric G-proteins and GPCRs, beginning in the 1970s. As in most such stories, formidable obstacles, confusion, and mistakes make eventual triumphs even more exciting.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::556dfe456b4ec9fb2873493eadfaeedc
https://doi.org/10.1007/2789_2006_001
https://doi.org/10.1007/2789_2006_001
Autor:
H R, Bourne, E C, Meng
Publikováno v:
Science (New York, N.Y.). 289(5480)
Members of the seven transmembrane receptor superfamily bind a remarkable variety of ligands, from neurotransmitters to odorants, and activate a spectacular array of G protein signaling molecules. These G-protein coupled receptors (GPCRs) are importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::913dc9aea29101a57d21e941f40fe6ed
https://pubmed.ncbi.nlm.nih.gov/10926528
https://pubmed.ncbi.nlm.nih.gov/10926528
Publikováno v:
The Journal of biological chemistry. 274(26)
The subcellular location of a signaling protein determines its ability to transmit messages accurately and efficiently. Three different lipid modifications tether heterotrimeric G proteins to membranes: alpha subunits are myristoylated and/or palmito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0054cdbf5f0d059c85f4eee68c67664d
https://pubmed.ncbi.nlm.nih.gov/10373496
https://pubmed.ncbi.nlm.nih.gov/10373496
Autor:
S P, Sheikh, J P, Vilardarga, T J, Baranski, O, Lichtarge, T, Iiri, E C, Meng, R A, Nissenson, H R, Bourne
Publikováno v:
The Journal of biological chemistry. 274(24)
The seven transmembrane helices of serpentine receptors comprise a conserved switch that relays signals from extracellular stimuli to heterotrimeric G proteins on the cytoplasmic face of the membrane. By substituting histidines for residues at the cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a8310ed764eebf6a9fb74f067ac63fe
https://pubmed.ncbi.nlm.nih.gov/10358054
https://pubmed.ncbi.nlm.nih.gov/10358054
Autor:
T J, Baranski, P, Herzmark, O, Lichtarge, B O, Gerber, J, Trueheart, E C, Meng, T, Iiri, S P, Sheikh, H R, Bourne
Publikováno v:
The Journal of biological chemistry. 274(22)
Hormones and sensory stimuli activate serpentine receptors, transmembrane switches that relay signals to heterotrimeric guanine nucleotide-binding proteins (G proteins). To understand the switch mechanism, we subjected 93 amino acids in transmembrane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0eec837980388f5b1c5162a24c60085b
https://pubmed.ncbi.nlm.nih.gov/10336477
https://pubmed.ncbi.nlm.nih.gov/10336477
Publikováno v:
The Journal of biological chemistry. 273(44)
G proteins transmit signals from cell surface receptors to intracellular effectors. The intensity of the signal is governed by the rates of GTP binding (leading to subunit dissociation) and hydrolysis. Mutants that cannot hydrolyze GTP (e.g. GsalphaQ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1cfc51030392a904884168e47a04873
https://pubmed.ncbi.nlm.nih.gov/9786851
https://pubmed.ncbi.nlm.nih.gov/9786851
Publikováno v:
Molecular biology of the cell. 9(1)
Three covalent attachments anchor heterotrimeric G proteins to cellular membranes: the alpha subunits are myristoylated and/or palmitoylated, whereas the gamma chain is prenylated. Despite the essential role of these modifications in membrane attachm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fbf704cbd00f138bc9ce9dd2f11f12a
https://pubmed.ncbi.nlm.nih.gov/9436987
https://pubmed.ncbi.nlm.nih.gov/9436987
Autor:
E R, Neptune, H R, Bourne
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(26)
Many chemoattractants cause chemotaxis of leukocytes by stimulating a structurally distinct class of G protein-coupled receptors. To identify receptor functions required for chemotaxis, we studied chemotaxis in HEK293 cells transfected with receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ce974870ccb83f5cba48a2cc5e15968
https://pubmed.ncbi.nlm.nih.gov/9405640
https://pubmed.ncbi.nlm.nih.gov/9405640