Zobrazeno 1 - 10
of 770
pro vyhledávání: '"H Phillip Koeffler"'
Autor:
Rong Wang, Yuanyuan Mi, Jiang Ni, Yang Wang, Lingwen Ding, Xuebin Ran, Qiaoyang Sun, Soo Yong Tan, H Phillip Koeffler, Ninghan Feng, Yong Q Chen
Publikováno v:
Advanced Science, Vol 11, Iss 9, Pp n/a-n/a (2024)
Abstract Treatment of castration‐resistant prostate cancer (CRPC) is a long‐standing clinical challenge. Traditionally, CRPC drugs work by either reducing dihydrotestosterone biosynthesis or blocking androgen receptor (AR) signaling. Here it is d
Externí odkaz:
https://doaj.org/article/598b79c327864817bc781b8e5e7ce0ef
Autor:
Yueyuan Zheng, Benjamin Ziman, Allen S. Ho, Uttam K. Sinha, Li-Yan Xu, En-Min Li, H Phillip Koeffler, Benjamin P. Berman, De-Chen Lin
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-31 (2023)
Abstract Background As one of the most common malignancies, esophageal cancer has two subtypes, squamous cell carcinoma and adenocarcinoma, arising from distinct cells-of-origin. Distinguishing cell-type-specific molecular features from cancer-specif
Externí odkaz:
https://doaj.org/article/6b59f1cedad94224a5e59061095d1407
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0232068 (2020)
Cyclin Dependent Kinase 9 (CDK9) associates with Bromodomain and Extra-Terminal Domain (BET) proteins to promote transcriptional elongation by phosphorylation of serine 2 of RNAP II C-terminal domain. We examined the therapeutic potential of selectiv
Externí odkaz:
https://doaj.org/article/bd4947c0061948b79c7175703f612703
Autor:
Haiyan Yan, Kaishun Hu, Wenjing Wu, Yu Li, Huan Tian, Zhonghua Chu, H Phillip Koeffler, Dong Yin
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159954 (2016)
Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial. For example, overe
Externí odkaz:
https://doaj.org/article/1f4e52cae0e840dc92bd868b83d3725e
Autor:
Soichiro Sakamoto, Hiroshi Kawabata, Taro Masuda, Tatsuki Uchiyama, Chisaki Mizumoto, Katsuyuki Ohmori, H Phillip Koeffler, Norimitsu Kadowaki, Akifumi Takaori-Kondo
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139915 (2015)
Ferritin is an iron-storage protein composed of different ratios of 24 light (L) and heavy (H) subunits. The serum level of ferritin is a clinical marker of the body's iron level. Transferrin receptor (TFR)1 is the receptor not only for transferrin b
Externí odkaz:
https://doaj.org/article/7b73c2c52bdc4926882ec85019a0c0e6
Autor:
Hosadurga K Keerthy, Manoj Garg, Chakrabhavi D Mohan, Vikas Madan, Deepika Kanojia, Rangappa Shobith, Shivananju Nanjundaswamy, Daniel J Mason, Andreas Bender, Basappa, Kanchugarakoppal S Rangappa, H Phillip Koeffler
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e107118 (2014)
The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles from alcohols, malanonitrile and phenols
Externí odkaz:
https://doaj.org/article/ec334f3735274b5a85eba3c8c2d4fc77
Autor:
Suren Sarkissyan, Marianna Sarkissyan, Yanyuan Wu, Jessica Cardenas, H Phillip Koeffler, Jaydutt V Vadgama
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103534 (2014)
Studies from our laboratory and others have shown that cysteine-rich 61 (Cyr61) may be involved in tumor proliferation and invasion. In earlier studies, we demonstrated increased insulin-like growth factor-I (IGF-1) is associated with breast tumor fo
Externí odkaz:
https://doaj.org/article/6a5c4f81233d4b65b36cc48e8f35c39f
Autor:
Ryoko Okamoto, Sigal Gery, Adrian F Gombart, Xuping Wang, Lawrence W Castellani, Tadayuki Akagi, Shuang Chen, Moshe Arditi, Quoc Ho, Aldons J Lusis, Quanlin Li, H Phillip Koeffler
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85341 (2014)
The CCAAT/enhancer binding proteins (C/EBPs) are transcription factors involved in hematopoietic cell development and induction of several inflammatory mediators. C/EBPε is expressed only in myeloid cells including monocytes/macrophages. Atheroscler
Externí odkaz:
https://doaj.org/article/a0f767b34e7e42c9ae4630ef2b72ad4f
Autor:
Dhruva K Mishra, Yanyuan Wu, Marianna Sarkissyan, Suren Sarkissyan, Zujian Chen, Xiying Shang, May Ong, David Heber, H Phillip Koeffler, Jaydutt V Vadgama
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57967 (2013)
Vitamin D plays a role in cancer development and acts through the vitamin D receptor (VDR). Although African-Americans have the lowest levels of serum vitamin D, there is a dearth of information on VDR gene polymorphisms and breast cancer among Afric
Externí odkaz:
https://doaj.org/article/db58245ddd2d437789ce787d7e4b5b94
Autor:
Dong Yin, Wangrong G Yang, Jack Weissberg, Catherine B Goff, Weikai Chen, Yoshio Kuwayama, Amanda Leiter, Hongtao Xing, Antonie Meixel, Daria Gaut, Fikret Kirkbir, David Sawcer, P Thomas Vernier, Jonathan W Said, Martin A Gundersen, H Phillip Koeffler
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43891 (2012)
Nanosecond pulsed electric fields (nsPEF) induce apoptotic pathways in human cancer cells. The potential therapeutic effective of nsPEF has been reported in cell lines and in xenograft animal tumor model. The present study investigated the ability of
Externí odkaz:
https://doaj.org/article/b4aae9c2b5254419b1ea48d99254aad2