Zobrazeno 1 - 10
of 121
pro vyhledávání: '"H Peter, Larsson"'
Autor:
Alessia Golluscio, Jodene Eldstrom, Jessica J Jowais, Marta Elena Perez, Kevin Peter Cunningham, Alicia De La Cruz, Xiaoan Wu, Valentina Corradi, D Peter Tieleman, David Fedida, H Peter Larsson
Publikováno v:
eLife, Vol 13 (2024)
In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause long QT syndrome (LQTS), a syndrome with a prolo
Externí odkaz:
https://doaj.org/article/3b70b86ed7a5417386c6095c41baafa2
Autor:
Briana M Bohannon, Jessica J Jowais, Leif Nyberg, Vanessa Olivier-Meo, Valentina Corradi, D Peter Tieleman, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 12 (2023)
Voltage-gated potassium (KV) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. KV channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for
Externí odkaz:
https://doaj.org/article/7551a63ea06f42c399ecf18db23a441f
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
The congenital Long QT Syndrome (LQTS) is an inherited disorder in which cardiac ventricular repolarization is delayed and predisposes patients to cardiac arrhythmias and sudden cardiac death. LQT1 and LQT5 are LQTS variants caused by mutations in KC
Externí odkaz:
https://doaj.org/article/b82245643f194de493efe87c08a421c1
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Wu et al. demonstrate that KCNE1 exerts its effects on potassium channel KCNQ1 function by regulating the coupling between the voltage-sensing domain and pore domain via KCNE1-induced rotation. As a consequence of this rotation, residue clashes occur
Externí odkaz:
https://doaj.org/article/5b4b4545350a401c9a25abae93fba693
Autor:
Lei Chen, Gary Peng, Thomas W. Comollo, Xinle Zou, Kevin J. Sampson, H. Peter Larsson, Robert S. Kass
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
ML277 and R-L3 are two small-molecule activators of KCNQ1, the pore-forming subunit of the slowly activating potassium channel IKs. KCNQ1 loss-of-function mutations prolong cardiac action potential duration and are associated with long QT syndrome, w
Externí odkaz:
https://doaj.org/article/dc0f7846b506456bab9039c7f4785f9f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are essential for rhythmic activity in the heart and brain. Here authors reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between
Externí odkaz:
https://doaj.org/article/2e930f15eab946698c97b37cf9434cbf
Autor:
Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 9 (2020)
Externí odkaz:
https://doaj.org/article/916e39ef8eff457f849713b47ca7bd82
Autor:
Briana M Bohannon, Alicia de la Cruz, Xiaoan Wu, Jessica J Jowais, Marta E Perez, Derek M Dykxhoorn, Sara I Liin, H Peter Larsson
Publikováno v:
eLife, Vol 9 (2020)
The cardiac ventricular action potential depends on several voltage-gated ion channels, including NaV, CaV, and KV channels. Mutations in these channels can cause Long QT Syndrome (LQTS) which increases the risk for ventricular fibrillation and sudde
Externí odkaz:
https://doaj.org/article/e07a4e0605884ed9905949525bae0d17
Publikováno v:
Cell Reports, Vol 24, Iss 11, Pp 2908-2918 (2018)
Summary: Polyunsaturated fatty acid (PUFA) analogs represent a new class of potential anti-arrhythmic KV7.1 and KV7.1+KCNE1 channel activators. In this study, we describe dual independent activating effects of negatively charged PUFA analogs on KV7.1
Externí odkaz:
https://doaj.org/article/1aad31143aca4177bd176e648363e273
Autor:
Gerhard P. Dahl, Gregory E. Conner, Feng Qiu, Junjie Wang, Edward Spindler, Jason A. Campagna, H. Peter Larsson
Publikováno v:
EBioMedicine, Vol 10, Iss C, Pp 291-297 (2016)
Clevidipine, a dihydropyridine (DHP) analogue, lowers blood pressure (BP) by inhibiting l-type calcium channels (CaV1.2; gene CACNA1C) predominantly located in vascular smooth muscle (VSM). However, clinical observations suggest that clevidipine acts
Externí odkaz:
https://doaj.org/article/3196549b2b8c4a0a8ac181bd695efb67