Výsledky vyhledávání - "H Peter, Kleine"

Discovery of N-(4-Fluoro-3-methoxybenzyl)-6-(2-(((2S,5R)-5-(hydroxymethyl)-1,4-dioxan-2-yl)methyl)-2H-tetrazol-5-yl)-2-methylpyrimidine-4-carboxamide. A Highly Selective and Orally Bioavailable Matrix Metalloproteinase-13 Inhibitor for the Potential Treatment of Osteoarthritis

Publikováno v: Journal of Medicinal Chemistry. 59:313-327

Matrix metalloproteinase-13 (MMP-13) is a zinc-dependent protease responsible for the cleavage of type II collagen, the major structural protein of articular cartilage. Degradation of this cartilage matrix leads to the development of osteoarthritis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1bf588f2b187240a5d8f4d5ee2e305b
https://doi.org/10.1021/acs.jmedchem.5b01434

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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 3. Process Research and Development of a Diisopropylcarbodiimide and Catalytic 1-Hydroxybenzotriazole Peptide Coupling

Publikováno v: Organic Process Research & Development. 13:1088-1093

Studies directed toward the process research, development, and scale-up preparation of the potential αvβ3 integrin antagonist 1 are described. A convergent approach is detailed wherein tetrahydropyrimidine hydroxybenzoic acid 2 is linked to the β-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::733dff69b6ebf02a64d61a4be7a9b658
https://doi.org/10.1021/op900173f

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Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation

Autor: Johnson Timothy Allan, Kim Alfonsi, David Austen Perry, Thomas Lee Fevig, Mark H. Stefaniak, Mark A. Nagy, Sandra M. Jennings, H. Peter Kleine, Juan Colberg, Peter J. Dunn, Craig J. Knight

Publikováno v: Green Chem.. 10:31-36

Influencing and improving the environmental performance of a large multi-national pharmaceutical company can be achieved with the help of electronic education tools, backed up by site champions and strong site teams. This paper describes the developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49f76c1c6b89b7fd919ac47e0a94208b
https://doi.org/10.1039/b711717e

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R-Isomers of Arg-Gly-Asp (RGD) mimics as potent αvβ3 inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry. 15:3783-3800

The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discovery of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8d38d74f8d90c225cd3716f76ef91f6
https://doi.org/10.1016/j.bmc.2007.03.034

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Pilot-Plant Preparation of an αvβ3 Integrin Antagonist. Part 2. Synthesis of N-[2-(5-Hydroxy-4,6-tetrahydropyrimidine)]-3-amino-5-hydroxybenzoic Acid

Autor: Gerald A. Weisenburger, Joe T. Collins, D. Keith Anderson, Jerry D. Clark, H. Peter Kleine

Publikováno v: Organic Process Research & Development. 8:571-575

Studies directed toward the process research and development of a scalable method for preparing tetrahydropyrimidine 2, a key intermediate to the αvβ3 integrin antagonist 1, are described. A linear approach employing 3-amino-5-hydroxybenzoic acid,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66e51ecd058d17a4721b0649981a0c54
https://doi.org/10.1021/op049968w

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Pilot Plant Preparation of an αvβ3 Integrin Antagonist. Part 1. Process Research and Development of a (S)-β-Amino Acid Ester Intermediate: Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction

Autor: Edney Albert D, Carl M. Knable, Pierre-Jean Colson, D. Keith Anderson, Thomas Rogers, Donald J. Gallagher, Ajit S. Shah, H. Peter Kleine, Jerry D. Clark, James Murphy, Christine M. V. Moore, Neil Storer, Bruce E. Wise, Peter G. Ruminski, Gerald A. Weisenburger, Melissa K. Lantz

Publikováno v: Organic Process Research & Development. 8:51-61

Described are four process research investigations directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key intermediate to the αvβ3 integrin antagonist 1. Reported are an asymmetric Michael reac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54f87a82dd31eb7ccfa9af86ec1e1272
https://doi.org/10.1021/op034094j

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R-isomers of Arg-Gly-Asp (RGD) mimics as potent alphavbeta3 inhibitors

Publikováno v: Bioorganicmedicinal chemistry. 15(11)

The integrin alpha(v)beta(3), vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the discov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a0bd91c9e67f6a65c308d5b53b9f248
https://pubmed.ncbi.nlm.nih.gov/17399986

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Akademický článek

Green chemistry tools to influence a medicinal chemistry and research chemistry based organisation.

Autor: Kim Alfonsi, Juan Colberg, Peter J. Dunn, Thomas Fevig, Sandra Jennings, Timothy A. Johnson, H. Peter Kleine, Craig Knight, Mark A. Nagy, David A. Perry, Mark Stefaniak

Publikováno v: Green Chemistry; Jan2008, Vol. 10 Issue 1, p31-36, 6p

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Akademický článek

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