Výsledky vyhledávání - "H P, Willems"

Akademický článek

Tranexamic acid to prevent operation in chronic subdural haematoma (TORCH): study protocol for a randomised placebo-controlled clinical trial

Autor: S. Immenga, R. Lodewijkx, Y. B. W. E. M. Roos, S. Middeldorp, C. B. L. M. Majoie, H. C. Willems, W. P. Vandertop, D. Verbaan

Publikováno v: Trials, Vol 23, Iss 1, Pp 1-13 (2022)

Abstract Background Chronic subdural haematoma (cSDH) occurs mainly in the elderly. Surgical evacuation is effective, but in these old, often frail, patients with multi-comorbidity, surgery carries significant risks for future cognitive functioning a

Externí odkaz: https://doaj.org/article/e598cf3937a34b71b014f6dd042e9375

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Akademický článek

The impact and challenges of implementing CTCA according to the 2019 ESC guidelines on chronic coronary syndromes: a survey and projection of CTCA services in the Netherlands

Autor: T. P. W. van den Boogert, B. E. P. M. Claessen, S. M. Boekholdt, T. Leiner, R. Vliegenthart, S. F. Schuiling, J. R. Timmer, S. C. A. M. Bekkers, M. Voskuil, H. J. Siebelink, W. van Es, H. J. Lamb, M. Prokop, P. Damman, J. Stoker, H. C. Willems, J. P. Henriques, R. N. Planken

Publikováno v: Insights into Imaging, Vol 12, Iss 1, Pp 1-11 (2021)

Abstract Background The 2019 ESC-guidelines on chronic coronary syndromes (ESC-CCS) recommend computed tomographic coronary angiography (CTCA) or non-invasive functional imaging instead of exercise ECG as initial test to diagnose obstructive coronary

Externí odkaz: https://doaj.org/article/9199273cd0c54143a0fa73f119741475

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Akademický článek

Investigating the effectiveness of care delivery at an acute geriatric community hospital for older adults in the Netherlands: a protocol for a prospective controlled observational study

Autor: Rosanne van Seben, Bianca M Buurman, Marthe E Ribbink, Janet L Macneil-Vroomen, Irène Oudejans, R Franssen, W J Frenkel, M J Henstra, M A van Maanen, J L Parlevliet, E P van Poelgeest, M N Resodikromo, K J Kaland, N van der Velde, M E Visser, H C Willems

Publikováno v: BMJ Open, Vol 10, Iss 3 (2020)

Introduction Hospital admission in older adults with multiple chronic conditions is associated with unwanted outcomes like readmission, institutionalisation, functional decline and mortality. Providing acute care in the community and integrating effe

Externí odkaz: https://doaj.org/article/4ab40b3eb074498ea409062ebf6892ab

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Akademický článek

The Clinical Relevance of Hyperkyphosis: A Narrative Review

Autor: M. C. Koelé, W. F. Lems, H. C. Willems

Publikováno v: Frontiers in Endocrinology, Vol 11 (2020)

The kyphosis angle of the thoracic spine tends to increase with aging. Hyperkyphosis is a kyphosis angle, exceeding the normal range. This narrative literature review aims to provide an overview of the current literature concerning kyphosis measureme

Externí odkaz: https://doaj.org/article/d38e77587b0d4e9dbfbeddd87499a1a2

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Akademický článek

Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication

Autor: Gijs G. Zom, Marian M. J. H. P. Willems, Selina Khan, Tetje C. van der Sluis, Jan Willem Kleinovink, Marcel G. M. Camps, Gijsbert A. van der Marel, Dmitri V. Filippov, Cornelis J. M. Melief, Ferry Ossendorp

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)

Abstract Background Ligands for the Toll-like receptor (TLR) family can induce activation of cells of the innate immune system and are widely studied for their potential to enhance adaptive immunity. Conjugation of TLR2-ligand Pam3CSK4 to synthetic l

Externí odkaz: https://doaj.org/article/709a690ddcf245d583864fadeb597229

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Akademický článek

Design, automated synthesis and immunological evaluation of NOD2-ligand–antigen conjugates

Autor: Marian M. J. H. P. Willems, Gijs G. Zom, Nico Meeuwenoord, Ferry A. Ossendorp, Herman S. Overkleeft, Gijsbert A. van der Marel, Jeroen D. C. Codée, Dmitri V. Filippov

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1445-1453 (2014)

The covalent attachment of an innate immune system stimulating agent to an antigen can provide active vaccine modalities capable of eliciting a potent immune response against the incorporated antigen. Here we describe the design, automated synthesis

Externí odkaz: https://doaj.org/article/8ba07bdc89314fe592a28a8770e53ec6

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Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells

Autor: Herman S. Overkleeft, Ferry Ossendorp, Selina Khan, Nico J. Meeuwenoord, Niels R. M. Reintjens, Gijsbert A. van der Marel, Jeroen D. C. Codée, Gijs G. Zom, Dmitri V. Filippov, Marian M. J. H. P. Willems, Elena Tondini

Publikováno v: Bioconjugate Chemistry
Bioconjugate Chemistry, 30(4), 1150-1161

Simultaneous triggering of Toll-like receptors (TLRs) and NOD-like receptors (NLRs) has previously been shown to synergistically activate monocytes, dendritic cells and macrophages. We applied these properties in a T-cell vaccine setting by conjugati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfa099c31bf01da719c355cf100f9d3
https://doi.org/10.1021/acs.bioconjchem.9b00087

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Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication

Autor: Dmitri V. Filippov, Gijsbert A. van der Marel, Cornelis J. M. Melief, Ferry Ossendorp, Tetje C. van der Sluis, Marcel Camps, Selina Khan, Marian M. J. H. P. Willems, Gijs G. Zom, Jan Willem Kleinovink

Publikováno v: Journal for ImmunoTherapy of Cancer, 6(1), 146
Journal for ImmunoTherapy of Cancer
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-13 (2018)

Background Ligands for the Toll-like receptor (TLR) family can induce activation of cells of the innate immune system and are widely studied for their potential to enhance adaptive immunity. Conjugation of TLR2-ligand Pam3CSK4 to synthetic long pepti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb052180a741c8e229a769bfd4117ac4
http://hdl.handle.net/1887/67737

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An Enantioselective Organocatalytic Approach to Both Enantiomers of Lasubine II

Autor: Marian M. J. H. P. Willems, Floris L. van Delft, Ferdi van der Pijl, Jorge M. M. Verkade, Floris P. J. T. Rutjes, Peter J. L. M. Quaedflieg

Publikováno v: Journal of Organic Chemistry, 74, 3207-3210
Journal of Organic Chemistry, 74, 8, pp. 3207-3210

A concise stereoselective route providing access to both enantiomers of the bioactive quinolizidine alkaloid lasubine II has been developed. The enantioselectivity was introduced by taking advantage of a proline-catalyzed asymmetric Mannich reaction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3e3ad9163363edca482605671ec0519
https://doi.org/10.1021/jo900141f

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