Zobrazeno 1 - 7
of 7
pro vyhledávání: '"H P, Schane"'
Publikováno v:
Endocrinology. 114:1983-1989
The synthetic steroid nivazol lacks three of the substituents considered to be important for glucocorticoid activity, i.e. the 3-keto, the 11-hydroxy, and the 20-keto groups. Nevertheless, in the rat, nivazol has the activity profile of a glucocortic
Autor:
A. J. Anzalone, Gordon O. Potts, H. C. Neumann, Malcolm R. Bell, Robert G. Christiansen, John E. Creange, H. P. Schane, U. J. Salvador
Publikováno v:
Journal of medicinal chemistry. 27(7)
Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory act
Publikováno v:
Journal of medicinal chemistry. 20(3)
Metabolites of danazol (17 alpha-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol), an orally effective pituitary gonadotropin inhibitory agent devoid of estrogenic and progestational activites, were isolated from urine of a female subject who had taken d
Publikováno v:
Drugs. 19(5)
Publikováno v:
Fertility and sterility. 30(1)
Azastene (4,4,17alpha-trimethylandrost-5-eno[2,3-d]isoxazol-17-ol), when given orally to rats at a dose of 12 mg/kg once on day 10 of pregnancy, induced resorption of all fetuses and a precipitous decline of circulating progesterone levels in all tes
Publikováno v:
Chemischer Informationsdienst. 8
Metabolites of danazol (17 alpha-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol), an orally effective pituitary gonadotropin inhibitory agent devoid of estrogenic and progestational activites, were isolated from urine of a female subject who had taken d
Publikováno v:
Fertility and sterility. 30(3)
Azastene is an orally effective "luteolytic" agent in rhesus monkeys. In nonpregnant monkeys it reverses the human chorionic gonadotropin-stimulated increase in progesterone production and delay in the onset of menstruation, and, in inseminated monke