Výsledky vyhledávání - "H P, Hetherington"

Regional energetic dysfunction in hippocampal epilepsy

Autor: H. P. Hetherington, Jung H. Kim, A. Cohen-Gadol, Jullie W. Pan, Cynthia Pan, Dennis D. Spencer

Publikováno v: Acta neurologica Scandinavica. 111(4)

Objectives – There is increasing evidence for a dysfunctional metabolic network in human mesial temporal lobe epilepsy (MTLE). To further describe this, we evaluated the bioenergetic status in unilateral MTLE inter-regionally and in relation to neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d096d3eab52c69c2da638b8424ba4df3
https://pubmed.ncbi.nlm.nih.gov/15740571

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Metabolic differences between multiple sclerosis subtypes measured by quantitative MR spectroscopy

Autor: H P Hetherington, John N. Whitaker, Khurram Bashir, Lauren B. Krupp, Patricia K. Coyle, J W Pan

Publikováno v: Multiple sclerosis (Houndmills, Basingstoke, England). 8(3)

We used quantitative magnetic resonance (MR) spectroscopic imaging with T1-based image segmentation to evaluate the subtypes of multiple sclerosis (MS) (eight patients each group of relapsing-remitting [RR], secondary progressive [SP] and primary pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d16b9ba301225fe379bc757d8364811
https://pubmed.ncbi.nlm.nih.gov/12120690

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Measurement of beta-hydroxybutyrate in acute hyperketonemia in human brain

Autor: J W, Pan, F W, Telang, J H, Lee, R A, de Graaf, D L, Rothman, D T, Stein, H P, Hetherington

Publikováno v: Journal of neurochemistry. 79(3)

We report the measurement of D-beta-hydroxybutyrate (BHB) in the brains of six normal adult subjects during acute infusions of BHB. We used high field in vivo (1)H magnetic resonance (MR) spectroscopy in the occipital lobe in conjunction with an acut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8411c3dfa259df9095af5c32f3281f01
https://pubmed.ncbi.nlm.nih.gov/11701757

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Quantitative (31)P spectroscopic imaging of human brain at 4 Tesla: assessment of gray and white matter differences of phosphocreatine and ATP

Autor: H P, Hetherington, D D, Spencer, J T, Vaughan, J W, Pan

Publikováno v: Magnetic resonance in medicine. 45(1)

This report describes the implementation and application of a multicompartment analysis of (31)P spectroscopic imaging data to determine the tissue-specific heterogeneities in metabolite content in the human brain and surrounding tissue. Using this i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd4e9a6adc098e60ad577b96b0af6169
https://pubmed.ncbi.nlm.nih.gov/11146485

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Spectroscopic imaging of glutamate C4 turnover in human brain

Autor: J W, Pan, D T, Stein, F, Telang, J H, Lee, J, Shen, P, Brown, G, Cline, G F, Mason, G I, Shulman, D L, Rothman, H P, Hetherington

Publikováno v: Magnetic resonance in medicine. 44(5)

One-dimensional spectroscopic imaging of (13)C-4-glutamate turnover is performed in the human brain with a 6 cc nominal voxel resolution at 4T. Data were acquired with an indirect detection approach using a short spin echo single quantum (1)H-(13)C h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b69add10d5391fcbd880fbc1f947f919
https://pubmed.ncbi.nlm.nih.gov/11064400

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Measurements of human brain ethanol T(2) by spectroscopic imaging at 4 T

Autor: M K, Sammi, J W, Pan, F W, Telang, D, Schuhlein, P E, Molina, N D, Volkow, C S, Springer, H P, Hetherington

Publikováno v: Magnetic resonance in medicine. 44(1)

Previous MRS measurements of ethanol in human brain have yielded a range of transverse relaxation times for ethanol methyl resonance at 1.5 T (200-380 ms). To determine the T(2) of the methyl proton resonance of ethanol in human brain, 8 x 8 spectros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04e10391a64269fb7528901e6a26ba27
https://pubmed.ncbi.nlm.nih.gov/10893519

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Statistically driven identification of focal metabolic abnormalities in temporal lobe epilepsy with corrections for tissue heterogeneity using 1H spectroscopic imaging

Autor: W J, Chu, R I, Kuzniecky, J W, Hugg, B, Abou-Khalil, F, Gilliam, E, Faught, H P, Hetherington

Publikováno v: Magnetic resonance in medicine. 43(3)

1H spectroscopic imaging of N-acetyl-aspartate, creatine, and choline has proven to be a sensitive indicator for the lateralization of seizure foci in temporal lobe epilepsy. Previous studies have used right-left comparisons to identify the epileptog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::caed2b83c929f79f596525ec8bb45906
https://pubmed.ncbi.nlm.nih.gov/10725878

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Non-P(i) buffer capacity and initial phosphocreatine breakdown and resynthesis kinetics of human gastrocnemius/soleus muscle groups using 0.5 s time-resolved (31)P MRS at 4.1 T

Autor: B R, Newcomer, M D, Boska, H P, Hetherington

Publikováno v: NMR in biomedicine. 12(8)

High-time-resolution (0.5 s) (31)P MRS has been used to evaluate the initial phosphoreatine (PCr) breakdown and resynthesis kinetics, to calculate the non-P(i)(/non-bicarbonate) buffer capacity (betanon-P(i)(/non-bicarb)), and to calculate the consta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bce25599079750c4181320e986c49ca3
https://pubmed.ncbi.nlm.nih.gov/10668047

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31P MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake

Autor: D E, Larson-Meyer, B R, Newcomer, G R, Hunter, H P, Hetherington, R L, Weinsier

Publikováno v: NMR in biomedicine. 13(1)

The reliability, relation to whole-body maximal oxygen uptake (VO(2max)), and force-level sensitivity of (31)P MRS markers of mitochondrial function were studied in 39 normal-weight women. Following 90 s isometric plantar-flexion exercises at 45, 70

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa6ee972deefb420ba85d037181ca2f3
https://pubmed.ncbi.nlm.nih.gov/10668050

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Spectroscopic imaging of the uptake kinetics of human brain ethanol

Autor: H P, Hetherington, F, Telang, J W, Pan, M, Sammi, D, Schuhlein, P, Molina, N D, Volkow

Publikováno v: Magnetic resonance in medicine. 42(6)

Previous measurements of the ratio of brain to venous blood alcohol have ranged from 21-100%, depending on the experimental model, pulse sequence, and the concentration reference used. The goal of this study was to evaluate the uptake kinetics and vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a27645679717d653d8b96d81551f99e2
https://pubmed.ncbi.nlm.nih.gov/10571922

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