Zobrazeno 1 - 10
of 382
pro vyhledávání: '"H Nariuchi"'
Publikováno v:
The Journal of Immunology. 162:6433-6441
Bioactive IL-12 is composed of two subunits, p35 and p40. In the APC-Th cell interaction, p40 mRNA accumulation in APC was shown to be up-regulated by stimulation with CD40 ligand (CD40L) on Th cells. However, the CD40-CD40L interaction scarcely indu
Publikováno v:
Journal of Experimental Medicine. 184:1449-1459
We have revealed that about one and a half thousand tiny clusters, filled with one thousand closely packed lymphocytes, can be found throughout the murine small and large intestinal mucosa. They are located in crypt lamina propria (cryptopatches; CP)
Publikováno v:
The Journal of Immunology. 156:3932-3938
The mechanism of IL-12 production has been studied by stimulating macrophages or B cell lines with LPS, Staphylococcus aureus, or phorbol diester. However, since IL-12 plays an important role in the activation of T cells interacting with APC, it is i
Autor:
Naoki Ikeda, Shuichi Kaneko, Kenichi Kobayashi, Yasuni Nakanuma, Nakaba Fujioka, S Su, M Unoura, H Nariuchi, Kenichi Harada, Naofumi Mukaida
Publikováno v:
Infection and Immunity. 63:4812-4817
Acute lethality was induced in rabbits by the sequential injection of Propionibacterium acnes and lipopolysaccharide (LPS). P. acnes induced the infiltration of inflammatory cells into the liver lobules during the early phase, and LPS in the late pha
Publikováno v:
The Journal of Immunology. 155:4692-4701
In the present experiments, TCR-CD3-associated early activation signal transduction pathways were examined in Th1 and Th2 clones by the stimulation with soluble monovalent anti-CD3 which resulted in efficient production of IL-2 and IL-4 in Th1 and Th
Publikováno v:
The Journal of Immunology. 154:1644-1652
DDD/1 (DDD) mice contrast strikingly with DDD-mtv-2/mtv-2 (DDD-mtv-2) congenics in their marked lymph node (LN) T cell paucity. To clarify the possible difference in LN function between them, reciprocal LN grafting experiments were conducted. DDD-mtv
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 120:636-640
We described previously that 10B atoms delivered by monoclonal antibody (mAb) exerted a cytotoxic effect on AH66 cells in a dose-dependent manner upon thermal neutron irradiation in vitro. In the present study, the delivering capacity of boronated an
Publikováno v:
The Journal of Immunology. 152:4919-4928
In these experiments, effects of IL-12 on the proliferation and IL-2R expression of Th1 and Th2 clones were studied. Although neither Th1 nor Th2 clones proliferated on an Ag stimulation with B cell APC, Th1 clones but not Th2 clones, exhibited IL-2-
Publikováno v:
The Journal of Immunology. 152:2130-2138
It has been reported that activated Th cells express CD40 ligand, and the interaction of the CD40 ligand and CD40 on B cells results in B cell cycle entry. In this report, mechanisms of B cell activation induced by CD40-CD40 ligand interaction were s
Publikováno v:
The Journal of Immunology. 151:6051-6061
To elucidate Th2 cell clone activation mechanism through TCR-CD3 complex, we examined the reactivity of Th2 cell clones to soluble anti-CD3 in the absence of accessory cells or costimulator. The soluble anti-CD3 stimulated IL-4 production of Th2 cell