Výsledky vyhledávání

Increased Generation of CD8+ T Cell Clones in p53 Mutant Mice

Autor: X, Zhou, S, Wong, J, Walter, T, Jacks, H N, Eisen

Publikováno v: The Journal of Immunology. 162:3957-3960

Very few cultured CD8+ T cell clones can normally be obtained from a single mouse and maintained in long-term culture. To improve the yield, we immunized p53 mutant mice with peptides of Sendai virus (FAPGNYPAL) and influenza virus (ASNENMETM) origin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba1f15fc0bb7c397cf393ea8f097602a
https://doi.org/10.4049/jimmunol.162.7.3957

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Tissue distribution of natural peptides derived from a ubiquitous dehydrogenase, including a novel liver-specific peptide that demonstrates the pronounced specificity of low affinity T cell reactions

Autor: M X Wu, T J Tsomides, H N Eisen

Publikováno v: The Journal of Immunology. 154:4495-4502

The peptides recognized by CD8+ CTL normally arise by proteolysis of intracellular proteins. To learn whether these peptides are generated similarly in diverse cell types, we examined the variety and abundance of naturally processed peptides that der

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45c8c9ac4f075309f1f3794b4166c4de
https://doi.org/10.4049/jimmunol.154.9.4495

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Variations in the number of peptide-MHC class I complexes required to activate cytotoxic T cell responses

Autor: S Kageyama, T J Tsomides, Y Sykulev, H N Eisen

Publikováno v: The Journal of Immunology. 154:567-576

We determined equilibrium constants for the binding of 16 peptides (based on four T cell epitopes) to three MHC class I proteins (A2, Kb, and Ld) on intact cells and estimated the number of accessible peptide-binding sites on these cells. From these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::415a3589412b2af0c659120990de9f14
https://doi.org/10.4049/jimmunol.154.2.567

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Akademický článek

Targeting Nuclear Receptor Coactivator SRC‐1 Prevents Colorectal Cancer Immune Escape by Reducing Transcription and Protein Stability of PD‐L1.

Autor: Hong, Yilin¹ (AUTHOR), Chen, Qiang^2,3 (AUTHOR), Wang, Zinan¹ (AUTHOR), Zhang, Yong¹ (AUTHOR), Li, Bei¹ (AUTHOR), Guo, Hanshi¹ (AUTHOR), Huang, Chuanzhong⁴ (AUTHOR), Kong, Xu⁵ (AUTHOR), Mo, Pingli¹ (AUTHOR), Xiao, Nengming¹ (AUTHOR), Xu, Jianming⁶ (AUTHOR), Ye, Yunbin⁴ (AUTHOR) zjyunbin@fjmu.edu.cn, Yu, Chundong^1,5 (AUTHOR) cdyu@xmu.edu.cn

Publikováno v: Advanced Science. 9/4/2024, Vol. 11 Issue 33, p1-18. 18p.

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Cognate peptide-induced destruction of CD8+ cytotoxic T lymphocytes is due to fratricide

Autor: M W Su, P R Walden, D B Golan, H N Eisen

Publikováno v: The Journal of Immunology. 151:658-667

In the absence of other cells, cloned CTL in culture can undergo massive destruction upon the addition of a peptide that is recognized, in association with the CTL's class I MHC proteins, by the CTL's Ag-specific TCR. To determine whether the destruc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8039c005462580f0f3d6604c328788a6
https://doi.org/10.4049/jimmunol.151.2.658

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