Zobrazeno 1 - 10
of 49
pro vyhledávání: '"H Martin Seidel"'
Autor:
Andrew T Miller, Carol Dahlberg, Mark L Sandberg, Ben G Wen, Daniel R Beisner, John A H Hoerter, Albert Parker, Christian Schmedt, Monique Stinson, Jacqueline Avis, Cynthia Cienfuegos, Mark McPate, Pamela Tranter, Martin Gosling, Paul J Groot-Kormelink, Janet Dawson, Shifeng Pan, Shin-Shay Tian, H Martin Seidel, Michael P Cooke
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inosi
Externí odkaz:
https://doaj.org/article/60911ac9821349a2a5779985bf95458d
Autor:
Sean B. Joseph, Paul Vincent Rucker, Peter McNamara, Michael Badman, Todd Groessl, Chianelli Donatella, Bo Liu, Alan Chu, Yugang Liu, Badry Bursulaya, H. Martin Seidel, Young Kim, John Nelson, Valentina Molteni, David C. Tully, David J Huang, Wendy Richmond, Andrew Phimister, Dingjiu Bao, Jane Wu, Thierry Schlama, Jason Roland, Eloy D. Hernandez, Bryan Laffitte, Jocelyn Zoll, Mahavir Prashad, Ignacio Sancho-Martinez, Robert Hill, Xiaodong Liu, James Schmeits
Publikováno v:
Journal of medicinal chemistry. 63(8)
Farnesoid X receptor (FXR) agonists are emerging as important potential therapeutics for the treatment of nonalcoholic steatohepatitis (NASH) patients, as they exert positive effects on multiple aspects of the disease. FXR agonists reduce lipid accum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308b3ff9affec6142819020e4a0d2b6c
https://pubmed.ncbi.nlm.nih.gov/31940200
https://pubmed.ncbi.nlm.nih.gov/31940200
Autor:
Stuart H Cole, Alana Althage, Xiaohan Xu, Shifeng Pan, Peter Gergely, Jörg H W Distler, Eric C. Svensson, Chun Li, Jennifer L. Harris, Christiane Maier, H. Martin Seidel, Nicholas Ng, Mindy H. Hsieh, Georg Schett, Jun Liu, Chih-Wei Chen, Thuong Trinh-Minh, Christian Beyer, Shelly Meeusen
Publikováno v:
Annals of the Rheumatic Diseases. 76:773-778
ObjectivesWnt signalling has been implicated in activating a fibrogenic programme in fibroblasts in systemic sclerosis (SSc). Porcupine is an O-acyltransferase required for secretion of Wnt proteins in mammals. Here, we aimed to evaluate the antifibr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1df10048412b094c49ab3e342e4081c
https://doi.org/10.1136/annrheumdis-2016-210294
https://doi.org/10.1136/annrheumdis-2016-210294
Autor:
H. Martin Seidel, Matthew Mangan, Gary D. Glick, William R. Roush, Edward James Olhava, Eicke Latz
Publikováno v:
Nature reviews / Drug discovery 17(8), 588-606 (2018). doi:10.1038/nrd.2018.97
Danger signals are a hallmark of many common inflammatory diseases, and these stimuli can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR- and pyrin domain-containing 3). Once activated, NLRP3 nucleates the assem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452c81946964c3bb37c11c4f5711bbe1
Autor:
Nanxin Li, Loren Jon, Fangxian Sun, Van Phung, AnneMarie Culazzo, Bin Hu, Jennifer L. Harris, Allen G. Li, Min Lu, Bo Liu, Zhicheng Wang, Yi Fan, Francisco Adrian, Susan McCormack, Ha-Soon Choi, Francois Gessier, Pamela A. Albaugh, Mahavir Prashad, Celine Tompkins, Andreas Kreusch, Chopiuk Greg, Valentina Molteni, Yong Jia, Tami Hood, Guoxun Liu, Apurva Chaudhary, Auzon Steffy, Tove Tuntland, H. Martin Seidel, Paul Vincent Rucker, Jianwei Che, Jie Li
Publikováno v:
ACS Medicinal Chemistry Letters. 6:562-567
Deregulated kinase activities of tropomyosin receptor kinase (TRK) family members have been shown to be associated with tumorigenesis and poor prognosis in a variety of cancer types. In particular, several chromosomal rearrangements involving TRKA ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd6c239d95be6f608edf1a7c739d3d29
https://doi.org/10.1021/acsmedchemlett.5b00050
https://doi.org/10.1021/acsmedchemlett.5b00050
Autor:
Young Kim, Tove Tuntland, H. Martin Seidel, Thomas H. Marsilje, Nanxin Li, Wei Pei, You-Qun He, Xiaoming Cui, Wendy Richmond, Markus Warmuth, Auzon Steffy, Alex Aycinena, Sungjoon Kim, W. Perry Gordon, Donald S. Karanewsky, AnneMarie Culazzo Pferdekamper, Jin Yunho, Jonathan Chang, Ruo Steensma, Jennifer L. Harris, Bo Liu, Sean B. Joseph, Yelena Sarkisova, Christian C. Lee, Todd Groessl, Bei Chen, Wenshuo Lu, Chopiuk Greg, Tao Jiang, Kevin Johnson, Tetsuo Uno, Pierre-Yves Michellys, Jiqing Jiang, Andrew Phimister, Allen G. Li, Nathanael S. Gray, Badry Bursulaya, Frank Sun, Yongqin Wan, Jie Li
Publikováno v:
Journal of Medicinal Chemistry. 56:5675-5690
The synthesis, preclinical profile, and in vivo efficacy in rat xenograft models of the novel and selective anaplastic lymphoma kinase inhibitor 15b (LDK378) are described. In this initial report, preliminary structure–activity relationships (SARs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85881c6ed23d1f9f401bd84a59439c2
https://doi.org/10.1021/jm400402q
https://doi.org/10.1021/jm400402q
Autor:
Auzon Steffy, Mindy H. Hsieh, Jie Li, H. Martin Seidel, Shifeng Pan, Wenqi Gao, Shailaja Kasibhatla, Dong Han, Celin Tompkins, Chun Li, Jun Liu, Nicholas Ng, Guobao Zhang, Dai Cheng, Fangxian Sun, Jennifer L. Harris
Publikováno v:
ACS medicinal chemistry letters. 7(7)
Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. We developed and performed a cellular high-throughput screen for inhibitors of Wnt secretion and pathway activation. A lead structure (GNF-1331) was identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13036703f64bfa25d4b056666a43468c
https://pubmed.ncbi.nlm.nih.gov/27437076
https://pubmed.ncbi.nlm.nih.gov/27437076
Autor:
Edward James Olhava, William R. Roush, Gary D. Glick, Matthew Mangan, H. Martin Seidel, Eicke Latz
Publikováno v:
Nature Reviews Drug Discovery. 17:688-688
Nature Reviews Drug Discovery 17, 588–606 (2018) A sentence mentioning the authors of reference 122 has been amended to include both corresponding authors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0e65d7c68395702d2e4e1be69f87d4e
https://doi.org/10.1038/nrd.2018.149
https://doi.org/10.1038/nrd.2018.149
Autor:
Yun He, Donald S. Karanewsky, Pingda Ren, Nathanael S. Gray, Xia Wang, Weitong Dong, Tracy A. Spalding, Jianwei Che, Zhiliang Wang, Mark L. Sandberg, Guobao Zhang, Yi Liu, H. Martin Seidel, Russell Romeo, Shin Shay Tian, Maya Iskandar, Taebo Sim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6691-6695
A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src-family kinases (SFKs). These type II inhibitors were optimized using a cellular Lck-dependent proliferation assay an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e0a8f71536c325ab9049aea3885d9d2
https://doi.org/10.1016/j.bmcl.2009.09.123
https://doi.org/10.1016/j.bmcl.2009.09.123
Autor:
Tracy A. Spalding, Enrique Saez, Yongping Xie, Andrea Gerken, Robert Epple, Vân T. B. Nguyêñ-Trân, Xing Wang, Donald S. Karanewsky, Cara Cuc Ngo, David S. Huang, Christopher Cow, Ross Russo, John Wityak, Tove Tuntland, H. Martin Seidel, Shin-Shay Tian, Mihai Azimioara, Maya Iskandar
Publikováno v:
Journal of Medicinal Chemistry. 53:77-105
The discovery, synthesis, and optimization of compound 1 from a high-throughput screening hit to highly potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) agonists are reported. The synthesis and structure-activity rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::489777559d3d46598f5c54e284a36080
https://doi.org/10.1021/jm9007399
https://doi.org/10.1021/jm9007399