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DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the RB1 gene promoter

Autor: Helen Dimaras, Anthony Raizis, Brenda L. Gallie, P M George, H M Racher, A Foucal

Publikováno v: Epigenetics

DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB(−/-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42cf74e15f496c1c948762ffa38ee51
https://doi.org/10.1080/15592294.2020.1834911

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