Zobrazeno 1 - 10
of 12
pro vyhledávání: '"H M, van Beuningen"'
Autor:
E.N. Blaney Davidson, W.B. van den Berg, F.A.J. van de Loo, H. M. van Beuningen, Elly L. Vitters, P.M. van der Kraan
Publikováno v:
Arthritis and Rheumatism, 56, 12, pp. 4065-73
Arthritis and Rheumatism, 56, 4065-73
Arthritis and Rheumatism, 56, 4065-73
Contains fulltext : 51836.pdf (Publisher’s version ) (Closed access) OBJECTIVE: Osteoarthritis (OA) is characterized by cartilage damage, synovial fibrosis, and osteophyte formation. Both transforming growth factor beta (TGFbeta) and bone morphogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34655d054c68e876fba7e9f7247eae4e
https://doi.org/10.1002/art.23034
https://doi.org/10.1002/art.23034
Publikováno v:
Osteoarthritis ISBN: 9783540651277
Osteoarthritis (OA) is characterized by focal lesions of the articular cartilage, and concomitant hypertrophic reactions in the bone compartment. The latter includes sclerosis in the subchondral bone and new bone formation at the joint margins, the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f980e926ed1d44d6e8dafb1d5c6fa708
https://doi.org/10.1007/978-3-642-60026-5_10
https://doi.org/10.1007/978-3-642-60026-5_10
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 78(2)
A severe consequence of rheumatoid arthritis is depletion of proteoglycans (PGs) from articular cartilage leading to functional impairment of this tissue. We investigated whether local administration of anabolic factors (transforming growth factors-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::73651fd587cf60d3af71bec6fb211f20
https://pubmed.ncbi.nlm.nih.gov/9484711
https://pubmed.ncbi.nlm.nih.gov/9484711
Autor:
W.B. van den Berg, F. van de Loo, B. van den Brand, Sharon Veenbergen, Miranda B. Bennink, P.M. van der Kraan, H. M. van Beuningen, Esmeralda Blaney-Davidson
Publikováno v:
Annals of the Rheumatic Diseases. 71:160.4-161
Background The intracellular suppressor of cytokine signaling (SOCS)-proteins are inducible and negative regulators in receptor signaling pathways of several cytokines, toll-like receptor ligands and some growth factors. We previously have shown in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08d2f2b04a4f8c734c6593cca0bf36b1
https://doi.org/10.1136/annrheumdis-2012-eular.1987
https://doi.org/10.1136/annrheumdis-2012-eular.1987
Autor:
P.L.E.M. van Lent, W.B. van den Berg, E.N. Blaney Davidson, M. H. van den Bosch, P.M. van der Kraan, Arjen B. Blom, F. A. van de Loo, H. M. van Beuningen
Publikováno v:
Annals of the Rheumatic Diseases. 72:A807.1-A807
Background Many osteoarthritis (OA) patients show significant synovial involvement. Recently, we found strong upregulation of canonical Wnts 2b and 16 and WISP1, a downstream protein, in the synovium in two murine OA models. Wnt signaling has been im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33bad871c4db4bac02624c11f7c6f69b
https://doi.org/10.1136/annrheumdis-2013-eular.2393
https://doi.org/10.1136/annrheumdis-2013-eular.2393
Autor:
H. M. van Beuningen, Anna M. Blom, M. H. van den Bosch, P.M. van der Kraan, E.N. Blaney Davidson, F. van de Loo, P.L.E.M. van Lent, W.B. van den Berg
Publikováno v:
Annals of the Rheumatic Diseases. 71:56.2-57
Background Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly induced expression of canonical Wnts 2b and 16 and WISP1, a downstream protein, in knee joints in two exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d7e838225bdbc627bd4d6427f2553ea
https://doi.org/10.1136/annrheumdis-2012-eular.1696
https://doi.org/10.1136/annrheumdis-2012-eular.1696
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 71(2)
High concentrations of active transforming growth factor-beta (TGF-beta) have been found in synovial fluids from arthritic joints. TGF-beta stimulates articular cartilage proteoglycan synthesis and suppresses proteoglycan degradation in vitro. In an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ae8d83c43be06588140079f1c62649d6
https://pubmed.ncbi.nlm.nih.gov/8078307
https://pubmed.ncbi.nlm.nih.gov/8078307
Publikováno v:
Agents and actions. Supplements. 39
Repeated intraarticular injections of transforming growth factor beta cause stimulation of articular cartilage proteoglycan synthesis, influx of inflammatory cells, fibrosis and osteophyte formation. When injected together with interleukin-1, TGF-bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ee915f806c8d634c5a4d033dd67011f
https://pubmed.ncbi.nlm.nih.gov/8456624
https://pubmed.ncbi.nlm.nih.gov/8456624
Publikováno v:
International journal of experimental pathology. 73(3)
We investigated the in-vivo proteoglycan synthesis in specific areas of murine knee joint articular cartilage after the induction of degenerative joint disease by means of 35S-sulphate autoradiography. Degenerative joint disease was induced either by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25ae70d927715446a5ccee285bed353d
https://pubmed.ncbi.nlm.nih.gov/1320394
https://pubmed.ncbi.nlm.nih.gov/1320394
Publikováno v:
Journal of experimental pathology (Oxford, England). 71(1)
A single intra-articular injection with bacterial collagenase in the right knee joints of 10-week-old male C57bl10 mice led to osteoarthritic lesions within a few weeks in these joints. The collagenase-induced osteoarthritis was characterized by seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12beccb5d71cc1d7bec87cfc134c5432
https://pubmed.ncbi.nlm.nih.gov/2155638
https://pubmed.ncbi.nlm.nih.gov/2155638