Zobrazeno 1 - 10
of 156
pro vyhledávání: '"H M, Grey"'
Autor:
S, Southwood, J, Sidney, A, Kondo, M F, del Guercio, E, Appella, S, Hoffman, R T, Kubo, R W, Chesnut, H M, Grey, A, Sette
Publikováno v:
The Journal of Immunology. 160:3363-3373
The peptide binding specificities of HLA-DRB1*0401, DRB1*0101, and DRB1*0701 have been analyzed by the use of large collections of synthetic peptides corresponding to naturally occurring sequences. The results demonstrated that nearly all peptides bi
Autor:
J Alexander, C Oseroff, J Sidney, P Wentworth, E Keogh, G Hermanson, F V Chisari, R T Kubo, H M Grey, A Sette
Publikováno v:
The Journal of Immunology. 159:4753-4761
Transgenic mice expressing chimeric human (alpha1 and alpha2 HLA-A11 domains) and murine (alpha3, transmembrane, and cytoplasmic H-2Kb domains) class I molecules were derived. These mice were used as a model system to study the immunogenicity of huma
Publikováno v:
The Journal of Immunology. 157:3480-3490
The HLA-B7-like binding supertype includes several different HLA-B molecules. Herein, the primary and secondary anchor specificities of the five most common HLA-B7-like molecules (B*0702, B*3501, B51, B*5301, and B*5401) were defined by the use of mo
Autor:
A Kondo, J Sidney, S Southwood, M F del Guercio, E Appella, H Sakamoto, E Celis, H M Grey, R W Chesnut, R T Kubo, A Sette
Publikováno v:
The Journal of Immunology. 155:4307-4312
The binding capacity of large sets of peptides corresponding to naturally occurring sequences and carrying previously defined A24-specific motifs was analyzed. It was found that only a minority (9-25%) of the motif-carrying peptides bound the relevan
Autor:
M E Ressing, A Sette, R M Brandt, J Ruppert, P A Wentworth, M Hartman, C Oseroff, H M Grey, C J Melief, W M Kast
Publikováno v:
The Journal of Immunology. 154:5934-5943
Human papillomavirus type 16 (HPV16) is strongly associated with cervical carcinogenesis. The HPV16 E6 and E7 oncoproteins are constitutively expressed in the majority of cervical tumor cells and are, therefore, attractive targets for CTL-mediated im
Publikováno v:
The Journal of Immunology. 154:685-693
Direct MHC binding assays with radiolabeled peptides and HLA class I-expressing mammalian cells such as EBV-transformed B cell lines and PHA-activated blasts have been developed. Significant binding of the radiolabeled probe could be obtained if the
Autor:
R T Kubo, A Sette, H M Grey, E Appella, K Sakaguchi, N Z Zhu, D Arnott, N Sherman, J Shabanowitz, H Michel
Publikováno v:
The Journal of Immunology. 152:3913-3924
Allele-specific motifs for the human MHC class I molecules, HLA-A1, A3, A11, and A24 were characterized by three complementary approaches. First, amino acid sequence analysis of acid eluted peptide pools from affinity purified class I molecules defin
Autor:
A Sette, J Sidney, C Oseroff, M F del Guercio, S Southwood, T Arrhenius, M F Powell, S M Colón, F C Gaeta, H M Grey
Publikováno v:
The Journal of Immunology. 151:3163-3170
In the present study, we describe the definition of a DRB1*0401 (DR4w4)-specific motif. The strategy used entailed a three-step process: 1) screening a large set of unrelated peptide ligands to identify good MHC binders; 2) truncation analysis of sev
Publikováno v:
The Journal of Immunology. 148:2446-2451
The T cell independence of complex polysaccharide Ag has suggested the possibility that carbohydrates may be incapable of T cell recognition because of a failure to interact with MHC restriction elements and/or a failure of MHC/carbohydrate complexes