Zobrazeno 1 - 6
of 6
pro vyhledávání: '"H M, Cherwinski"'
Publikováno v:
Journal of Biological Chemistry. 266:11738-11745
We have studied Ca2+ mobilization mediated by the constitutively expressed muscarinic receptor on a subclone of PC-12 cells. The subclone, ACH2, was isolated with a flow cytometer by selection of single cells that exhibited a strong intracellular Ca2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56d729fff97e1cdf6ffd57944708899e
https://doi.org/10.1016/s0021-9258(18)99019-8
https://doi.org/10.1016/s0021-9258(18)99019-8
Publikováno v:
Journal of Neurochemistry. 56:983-989
Single cell Ca2+ mobilization was studied by nonparametric, quantitative flow cytometry using a sort-selected subclone of PC-12 cells. The response of the parent PC-12 population to bradykinin (BK) was very heterogeneous and of a relatively low magni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271cb9590d461f3af62f818fd27db892
https://doi.org/10.1111/j.1471-4159.1991.tb02018.x
https://doi.org/10.1111/j.1471-4159.1991.tb02018.x
Autor:
H M, Cherwinski, R G, Cohn, P, Cheung, D J, Webster, Y Z, Xu, J P, Caulfield, J M, Young, G, Nakano, J T, Ransom
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(2)
Leflunomide is a novel immunosuppressive compound that is effective in the treatment of animal models of autoimmune disease and human rheumatoid arthritis. The mechanism of action is unknown. Here we show that leflunomide blocked 1) increases in nucl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e73377462f7e2718ce5d8a4508573288
https://pubmed.ncbi.nlm.nih.gov/7473131
https://pubmed.ncbi.nlm.nih.gov/7473131
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 44(8)
Leflunomide is an anti-inflammatory and immunosuppressive agent which blocks proliferation of transformed cells and mitogen stimulated normal lymphocytes but does not block T cell signalling mechanisms at antiproliferative concentrations. These prope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f6d87b1187a004fc74fd71e2813a3f
https://pubmed.ncbi.nlm.nih.gov/8581517
https://pubmed.ncbi.nlm.nih.gov/8581517
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(1)
Leflunomide is a novel and effective immunosuppressant that holds promise as a therapeutic agent, but the mechanism of action is unknown. Here we provide evidence that leflunomide is a general cytostatic agent for a wide range of cells. The IC50 for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9baeb83093eb7308f738f632f8876207
https://pubmed.ncbi.nlm.nih.gov/7529314
https://pubmed.ncbi.nlm.nih.gov/7529314
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 148(10)
Stimulation of an IL-2-dependent variant of the Th2 clone D10.G4.1 with antibodies (Ab) specific for CD3 epsilon or the TCR-alpha beta caused either activation of the clone to secrete the autocrine lymphokine IL-4, or lethal activation in which the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e83082b0f56a27642a90ee5602860c45
https://pubmed.ncbi.nlm.nih.gov/1533650
https://pubmed.ncbi.nlm.nih.gov/1533650