Výsledky vyhledávání - "H M, Bandara"

Akademický článek

Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

Autor: Washim Khan, Yan-Hong Wang, Narayan D. Chaurasiya, N. P. Dhammika Nanayakkara, H. M. Bandara Herath, Kerri A. Harrison, Gray Dale, Donald A. Stanford, Eric P. Dahl, James D. McChesney, Waseem Gul, Mahmoud A. ElSohly, David Jollow, Babu L. Tekwani, Larry A. Walker

Publikováno v: Frontiers in Pharmacology, Vol 13 (2023)

Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic drug

Externí odkaz: https://doaj.org/article/801eb27d382a49469704097ef32cf698

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Akademický článek

Formation primaquine-5,6-orthoquinone, the putative active and toxic metabolite of primaquine via direct oxidation in human erythrocytes

Autor: Pius S. Fasinu, N. P. Dhammika Nanayakkara, Yan-Hong Wang, Narayan D. Chaurasiya, H. M. Bandara Herath, James D. McChesney, Bharathi Avula, Ikhlas Khan, Babu L. Tekwani, Larry A. Walker

Publikováno v: Malaria Journal, Vol 18, Iss 1, Pp 1-8 (2019)

Abstract Background The activity and haemolytic toxicity associated with primaquine has been linked to its reactive metabolites. The reactive metabolites are thought to be primarily formed through the action of cytochrome P450-mediated pathways. Huma

Externí odkaz: https://doaj.org/article/bef9c2cb44b441a495645be8bf521194

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