Zobrazeno 1 - 10
of 75
pro vyhledávání: '"H Laustsen A"'
Autor:
Cecilie Knudsen, Selma B. Belfakir, Pelle Degnegaard, Jonas A. Jürgensen, Aleksander M. Haack, Rasmus U. W. Friis, Søren H. Dam, Andreas H. Laustsen, Georgina M. S. Ross
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bothrops and Lachesis are two of Brazil’s medically most relevant snake genera, causing tens of thousands of bites annually. Fortunately, Brazil has good accessibility to high-quality antivenoms at the genus and inter-genus level, enabling
Externí odkaz:
https://doaj.org/article/a71f334444ad48048cf817459bf6016a
Autor:
Christoffer V. Sørensen, Julián Fernández, Anna Christina Adams, Helen H. K. Wildenauer, Sanne Schoffelen, Line Ledsgaard, Manuela B. Pucca, Michael Fiebig, Felipe A. Cerni, Tulika Tulika, Bjørn G. Voldborg, Aneesh Karatt-Vellatt, J. Preben Morth, Anne Ljungars, Lise M. Grav, Bruno Lomonte, Andreas H. Laustsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Improved therapies are needed against snakebite envenoming, which kills and permanently disables thousands of people each year. Recently developed neutralizing monoclonal antibodies against several snake toxins have shown promise in preclini
Externí odkaz:
https://doaj.org/article/99301d927d1f464bb9fbaf12412f986c
Autor:
William Laprade, Keirah E. Bartlett, Charlotte R. Christensen, Taline D. Kazandjian, Rohit N. Patel, Edouard Crittenden, Charlotte A. Dawson, Marjan Mansourvar, Darian S. Wolff, Thomas Fryer, Andreas H. Laustsen, Nicholas R. Casewell, José María Gutiérrez, Steven R. Hall, Timothy P. Jenkins
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Snakebite envenoming is a global public health issue that causes significant morbidity and mortality, particularly in low-income regions of the world. The clinical manifestations of envenomings vary depending on the snake's venom, with paral
Externí odkaz:
https://doaj.org/article/6bbe56adfb85480a807ac5e7250494ff
Autor:
Christoffer V. Sørensen, Line Ledsgaard, Helen H. K. Wildenauer, Camilla H. Dahl, Tasja W. Ebersole, Markus-Frederik Bohn, Anne Ljungars, Timothy P. Jenkins, Andreas H. Laustsen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Antibodies with cross-reactive binding and broad toxin-neutralizing capabilities are advantageous for treating indications such as infectious diseases and animal envenomings. Such antibodies have been successfully selected against closely re
Externí odkaz:
https://doaj.org/article/dc0f626d0f1e4380a0b1f8a7a0308d17
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 29 (2023)
Abstract Snakebite envenoming is a significant global health challenge, and for over a century, traditional plasma-derived antivenoms from hyperimmunized animals have been the primary treatment against this infliction. However, these antivenoms have
Externí odkaz:
https://doaj.org/article/44dd0191766d4bb287cb302dcc0846fd
Autor:
Monica L. Fernández-Quintero, Anne Ljungars, Franz Waibl, Victor Greiff, Jan Terje Andersen, Torleif T. Gjølberg, Timothy P. Jenkins, Bjørn Gunnar Voldborg, Lise Marie Grav, Sandeep Kumar, Guy Georges, Hubert Kettenberger, Klaus R. Liedl, Peter M. Tessier, John McCafferty, Andreas H. Laustsen
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTBeyond potency, a good developability profile is a key attribute of a biological drug. Selecting and screening for such attributes early in the drug development process can save resources and avoid costly late-stage failures. Here, we review
Externí odkaz:
https://doaj.org/article/40e1d35a06264ee9a178e72c2e9b24b1
Publikováno v:
International Journal of Circumpolar Health, Vol 82, Iss 1 (2023)
ABSTRACTRigorous lung function prediction equations for the Inuit are lacking. We used spirometry from 351 Inuit and 29 people of other ancestry obtained during an occupational survey in Greenland to determine how to obtain valid lung function predic
Externí odkaz:
https://doaj.org/article/b583fa7986df403e92f38d7c7cf40b92
Autor:
Knudsen, Cecilie, Jürgensen, Jonas A., D. Knudsen, Pelle, Oganesyan, Irina, Harrison, Julian A., Dam, Søren H., Haack, Aleksander M., Friis, Rasmus U.W., Vitved, Lars, Belfakir, Selma B., Ross, Georgina M.S., Zenobi, Renato, H. Laustsen, Andreas
Publikováno v:
In Analytica Chimica Acta 1 September 2023 1272
Autor:
Line Ledsgaard, Jack Wade, Timothy P. Jenkins, Kim Boddum, Irina Oganesyan, Julian A. Harrison, Pedro Villar, Rachael A. Leah, Renato Zenobi, Sanne Schoffelen, Bjørn Voldborg, Anne Ljungars, John McCafferty, Bruno Lomonte, José M. Gutiérrez, Andreas H. Laustsen, Aneesh Karatt-Vellatt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The treatment of snakebite envenoming is currently suboptimal. Existing antivenoms often lack efficacy and may cause adverse reactions. Here, the authors derive, develop, and demonstrate the utility of toxin-specific broadly-neutralizing human monocl
Externí odkaz:
https://doaj.org/article/e25513bb2bca42949088d83d90b24bca
Autor:
Andrea Martos-Esteban, Olivia J. S. Macleod, Isabella Maudlin, Konstantinos Kalogeropoulos, Jonas A. Jürgensen, Mark Carrington, Andreas H. Laustsen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract African trypanosomes, such as Trypanosoma brucei, are flagellated protozoa which proliferate in mammals and cause a variety of diseases in people and animals. In a mammalian host, the external face of the African trypanosome plasma membrane
Externí odkaz:
https://doaj.org/article/52bcd530f9fe4bbc8ab500c9fce4cd8f