Zobrazeno 1 - 10
of 19
pro vyhledávání: '"H L Tiffany"'
Publikováno v:
Journal of Leukocyte Biology. 60:147-152
We have cloned a human cDNA for a novel CC chemokine receptor (CC CKR) designated CC CKR5 that has 48–75% amino acid identity to other CC CKRs. CC CKR5 mRNA was detected constitutively in primary adherent monocytes but not in primary neutrophils or
Publikováno v:
Journal of Leukocyte Biology. 58:49-54
We evaluated two independent models of eosinophil differentiation for their ability to synthesize the ribonuclease toxins eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP). Cells from the done 15 subline of HL-60 (human promye
Autor:
H L Tiffany, Helene F. Rosenberg
Publikováno v:
Journal of Leukocyte Biology. 56:502-506
Monoclonal antibodies EG1 and EG2 have the unique ability to distinguish the storage from the secreted forms of the eosinophil cationic protein (ECP). EG2 has been used extensively as a marker for activated, secreting eosinophils, despite the fact th
Publikováno v:
Journal of Biological Chemistry. 269:26381-26389
Human neutrophils are highly responsive to the chemokine interleukin-8 (IL-8) owing to high levels of expression of two related receptors encoded by the single copy genes il8ra and il8rb located on chromosome 2q34-q35. To identify nuclear factors tha
Publikováno v:
Biochemical and Biophysical Research Communications. 201:174-179
The human genes for two N-formylpeptide phagocyte chemoattractant receptors (gene symbols FPR1 and FPRL1) cross-hybridize with each other and with FPRL2, a human gene of unknown expression and function. The FPR1 product is approximately 1000-fold mor
Autor:
U. Francke, Xu Li, Douglas B. Kuhns, Philip M. Murphy, Ji-Liang Gao, H L Tiffany, David H. McDermott
Publikováno v:
The Journal of Experimental Medicine
The chemokine beta family is comprised of at least six distinct cytokines that regulate trafficking of phagocytes and lymphocytes in mammalian species; at least one of these, macrophage inflammatory protein 1 alpha (MIP-1 alpha), also regulates the g
Publikováno v:
The Journal of Immunology. 145:2227-2234
Platelet activating factor (PAF) and the active cleavage product of the fifth component of complement, C5a, are potent anaphylotoxins and mediators of inflammation. Both substances engage distinct guanine nucleotide binding regulatory protein-coupled
Autor:
Philip M. Murphy, H L Tiffany
Publikováno v:
Journal of Biological Chemistry. 265:11615-11621
Stimulation of phagocytic cells with micromolar concentrations of extracellular ATP primes the production of toxic oxygen metabolites in response to chemoattractants and independently activates a secretory response in vitro. It is hypothesized that e
Publikováno v:
Biochemical and biophysical research communications. 253(3)
Human fractalkine and its apparent murine counterpart neurotactin are the only members identified so far of the CX3C subfamily of chemokines. Recently, a human fractalkine receptor was identified and named CX3CR1. Here we have identified a mouse coun
Autor:
B, Nardelli, H L, Tiffany, G W, Bong, P A, Yourey, D K, Morahan, Y, Li, P M, Murphy, R F, Alderson
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(1)
The receptor specificity and signal transduction pathway has been identified and characterized for a truncated form of myeloid progenitor inhibitory factor-1 (MPIF-1(24-99)). MPIF-1 binds specifically to sites, in particular CCR1, shared with macroph