Zobrazeno 1 - 10
of 44
pro vyhledávání: '"H L Sharp"'
Publikováno v:
Journal of Lipid Research, Vol 17, Iss 3, Pp 294-297 (1976)
An enzyme assay was developed to measure the conversion of the bile acid precursor, 3α, 7α, 12α-trihydroxy-5β-cholestan-26-oic acid (THCA), into cholic acid using homogenates of human liver biopsies. The average rate of metabolism of THCA into ch
Externí odkaz:
https://doaj.org/article/34891b2839574516aea90d01e4f57a05
Autor:
H L Sharp, J P Richards, J F Glover, Timothy Mant, L Sjostrom, Terence Bennett, Alan Rushton, M R Downham, A Rosul, Sheila M. Gardiner, T R Auton
Publikováno v:
British Journal of Clinical Pharmacology. 56:505-512
Aims We aim to modulate the renin–angiotensin system (RAS) by active immunization against angiotensin I hormone (AI), potentially providing a novel conjugate vaccine treatment for hypertension in man. Methods Immunization studies in rat and human s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e030243087d11c9927bbf54c600563f1
https://doi.org/10.1046/j.1365-2125.2003.01926.x
https://doi.org/10.1046/j.1365-2125.2003.01926.x
Autor:
Phillip John Morgan, Terence Bennett, M R Downham, H L Sharp, T R Auton, J F Glover, Harry Martin, Alan Rushton, Julie E. March, P.A. Kemp, Sheila M. Gardiner
Publikováno v:
British Journal of Pharmacology. 129:1178-1182
Male, Sprague-Dawley rats were actively immunized with novel angiotensin vaccines, and their pressor responses to exogenous angiotensin I (AI) and angiotensin II (AII) were assessed in vivo. Serum antibody titres were also measured. The most effectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7d4603f08ccfdce58a3fbe8a57f1610
https://doi.org/10.1038/sj.bjp.0703178
https://doi.org/10.1038/sj.bjp.0703178
Autor:
M R, Downham, T R, Auton, A, Rosul, H L, Sharp, L, Sjöström, A, Rushton, J P, Richards, T G K, Mant, S M, Gardiner, T, Bennett, J F, Glover
Publikováno v:
British journal of clinical pharmacology. 56(5)
We aim to modulate the renin-angiotensin system (RAS) by active immunization against angiotensin I hormone (AI), potentially providing a novel conjugate vaccine treatment for hypertension in man.Immunization studies in rat and human subjects compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::915725f8b1e4042dfb2aeeac8ada08e4
https://pubmed.ncbi.nlm.nih.gov/14651724
https://pubmed.ncbi.nlm.nih.gov/14651724
Autor:
S M, Gardiner, T R, Auton, M R, Downham, H L, Sharp, P A, Kemp, J E, March, H, Martin, P J, Morgan, A, Rushton, T, Bennett, J F, Glover
Publikováno v:
British journal of pharmacology. 129(6)
1. Male, Sprague-Dawley rats were actively immunized with novel angiotensin vaccines, and their pressor responses to exogenous angiotensin I (AI) and angiotensin II (AII) were assessed in vivo. Serum antibody titres were also measured. 2. The most ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a96c0d0e48a270ba4ac7ef1f9d60ab6
https://pubmed.ncbi.nlm.nih.gov/10725266
https://pubmed.ncbi.nlm.nih.gov/10725266
Autor:
S J, Schwarzenberg, H L, Sharp
Publikováno v:
Pediatric clinics of North America. 43(1)
Wilson's disease, genetic and neonatal hemochromatosis, protoporphyria, tyrosinemia, and alpha1-antitrypsin deficiency are updated. Cost effectiveness of screening is discussed. Current therapies are evaluated, including the role of transplantation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ee55e7172bc80afea6675a6ea089a55
https://pubmed.ncbi.nlm.nih.gov/8596684
https://pubmed.ncbi.nlm.nih.gov/8596684
Publikováno v:
Hepatology (Baltimore, Md.). 13(5)
In an effort to better understand chronic liver transplant rejection, we studied 110 children and adults who survived for at least 2 mo after the transplant procedure. Chronic rejection was defined using a combination of clinical and histopathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c86322c9bfd08c7435b27a8a793a6808
https://pubmed.ncbi.nlm.nih.gov/2029992
https://pubmed.ncbi.nlm.nih.gov/2029992
Publikováno v:
The Journal of laboratory and clinical medicine. 90(3)
Patients with a metabolic block in the conversion of THCA into cholic acid develop cirrhosis and hemolysis, and die of hepatic failure. In these patients, THCA is largely conjugated to taurine (tauro-THCA) and excreted instead of being converted into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::360e2dc21fca4840f9fd1e1c1f8ec478
https://pubmed.ncbi.nlm.nih.gov/894105
https://pubmed.ncbi.nlm.nih.gov/894105
Publikováno v:
Surgical neurology. 6(2)
Report of the successful use of a decompressive craniectomy for the encephalopathy of Reye's syndrome with increased intracranial pressure. The patient had failed to respond to all medical management.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::db06b16d4e5eff3577aa24efaa80f196
https://pubmed.ncbi.nlm.nih.gov/951659
https://pubmed.ncbi.nlm.nih.gov/951659
Publikováno v:
Transplantation proceedings. 19(1 Pt 3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2f784549783ea062ff65e1ff805fc63
https://pubmed.ncbi.nlm.nih.gov/3274537
https://pubmed.ncbi.nlm.nih.gov/3274537