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Autor:
H L Lamain, A J J Van Ooyen, R F Evers, J. A. Van Mourik, M Ph Verbeet, Hans Pannekoek, A Leyte
Publikováno v:
XIth International Congress on Thrombosis and Haemostasis.
Factor VIII (FVIII) consists of an obvious domain structure that can be represented as A1-A2-B-A3-C1-C2 (Vehar et al., 1984, Nature 312, 337). In order to determine the domains involved in the procoagulant activity of FVIII, we constructed mutant FVI