Zobrazeno 1 - 10
of 22
pro vyhledávání: '"H L, Sham"'
Autor:
Patel Ketan M, Jien-Heh J. Tien, Lawrence Kolaczkowski, Joseph B. Paterson, Arthur J. Cooper, and Peter J. Stengel, Jih-Hua Liu, Daniel J. Plata, Patricia A. Oliver-Shaffer, David A. Riley, Daniel A. Dickman, H. L. Sham, Eric J. Stoner, John E. Lallaman
Publikováno v:
Organic Process Research & Development. 4:264-269
A large scale process for the synthesis of HIV protease inhibitor candidate ABT-378 has been developed which utilizes an intermediate common to the synthesis of ritonavir, Abbott's first generation compound. The synthesis relies on the sequential acy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ee1d1cf451e53c6ebab1944c57cf71
https://doi.org/10.1021/op990202j
https://doi.org/10.1021/op990202j
Autor:
H. L. Sham, Warren M. Kati, A Buko, G T Wang, W Rosenbrook, D A Montgomery, L Miesbauer, J O McCall, D W Norbeck
Publikováno v:
Archives of Biochemistry and Biophysics. 362:363-375
The gene coding for the 3C protease from human rhinovirus strain 1B was efficiently expressed in an Escherichia coli strain which also overexpressed the rare argU tRNA. The protease was isolated from inclusion bodies, refolded, and exhibited a kcat/K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dccc70f7ca6d403b54da0d76bcb187e8
https://doi.org/10.1006/abbi.1998.1038
https://doi.org/10.1006/abbi.1998.1038
Autor:
D. J. Kempf, H. L. Sham
Publikováno v:
Current Pharmaceutical Design. 2:225-246
The protease encoded by the human immunodeficiency virus (HIV protease) mediates the maturation of newly formed HIV particles through proteolytic processing of the gag and gag-pol gene products. Because of its essential role in the HIV replication cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f7237dbbddedb755a74cf24a8816111
https://doi.org/10.2174/1381612802666220921175941
https://doi.org/10.2174/1381612802666220921175941
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd75435c24424abad73bd2e8bbbe19b
https://doi.org/10.1002/chin.199102322
https://doi.org/10.1002/chin.199102322
Autor:
H. L. Sham
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28fda94bd19c6b369606efe7bdc06529
https://doi.org/10.1002/chin.199603301
https://doi.org/10.1002/chin.199603301
Autor:
H. L. Sham, Kent D. Stewart, Kennan C. Marsh, Chang H. Park, Thomas Herrin, Xiang-Peng Kong, C. Zhao, Dale J. Kempf, David A. Betebenner, J. J. Plattner, Akhter Molla, T. Robins, D. W. Norbeck, Shuqun Lin, Ayda Saldivar, N. Lyons, Darold L. Madigan, W. Jun. Rosenbrook, Edith McDonald, Jon F. Denissen, Norman Wideburg, Suthida Vasavanonda
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a6f00d92d07b9ab95319d0efe6ff86a
https://doi.org/10.1002/chin.199619188
https://doi.org/10.1002/chin.199619188
Autor:
Earl R. Kern, William Rosenbrook, H. L. Sham, S. Hayashi, Jacob J. Plattner, Robert N. Swanson, Jacob J. Clement, J Erickson, D. W. Norbeck, Thomas Herrin
Publikováno v:
Journal of Medicinal Chemistry. 33:1281-1285
Given the complex involvement of herpesviruses in the pathogenesis of AIDS, an agent capable of controlling the replication of both HIV and herpesviruses may offer special benefits in AIDS therapy. In response to this need, we report here the synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35062d389edcb3a49383abf6d4301fb
https://doi.org/10.1021/jm00167a002
https://doi.org/10.1021/jm00167a002
Publikováno v:
Biochemical and biophysical research communications. 244(2)
The kinetics of inhibition of purified influenza neuraminidases from A/Tokyo/3/67 and B/Memphis/3/89 influenza viruses by (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylic acid (GS4071) were investigated. Progress curve exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9fdf1b37b42c5b517ca90a0c3e5c5d
https://pubmed.ncbi.nlm.nih.gov/9514938
https://pubmed.ncbi.nlm.nih.gov/9514938
Autor:
H. L. Sham, Sudthida Vasavanonda, Edith McDonald, J. J. Plattner, Shuqun Lin, D. W. Norbeck, Ayda Saldivar, T. Robins, K. C. Marsh, Chen Zhao, Dale J. Kempf, Norman Wideburg, David A. Betebenner
Publikováno v:
Biochemical and biophysical research communications. 211(1)
A series of novel pseudo-symmetrical and unsymmetrical inhibitors based on the backbone modification of a peptidomimetic were synthesized and found to be highly potent inhibitors of the HIV-1 protease (IC50 = 2.9 to < 0.5 nM). These compounds also po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebdbdb1d2d8ed57a63760aa8d72c16c
https://pubmed.ncbi.nlm.nih.gov/7779082
https://pubmed.ncbi.nlm.nih.gov/7779082
Publikováno v:
Advances in experimental medicine and biology. 362
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7fb9623f74991bc56e1e1ce66083f22
https://pubmed.ncbi.nlm.nih.gov/8540356
https://pubmed.ncbi.nlm.nih.gov/8540356