Zobrazeno 1 - 10
of 15
pro vyhledávání: '"H L, Ostergaard"'
Autor:
N N Berg, H L Ostergaard
Publikováno v:
The Journal of Immunology. 159:1753-1757
Stimulation through the TCR is known to induce tyrosine phosphorylation of a number of proteins, which leads to functional activation of T cells. Identification of the substrates that become phosphorylated and defining their interactions with other s
Publikováno v:
The Journal of Immunology. 155:5095-5103
CD45 is a transmembrane protein tyrosine phosphatase required for signal transduction through the Ag receptor complexes of T and B lymphocytes. Herein, we demonstrate that immobilized mAbs to the external domain of CD45 induce rapid and dramatic morp
Autor:
N N Berg, H L Ostergaard
Publikováno v:
The Journal of Immunology. 155:1694-1702
Purified intercellular adhesion molecule-1 (ICAM-1), a ligand of the LFA-1, was used to analyze the contribution of ICAM-1 to the activation of CTL. ICAM-1 facilitates degranulation when co-immobilized with substimulatory amounts of anti-CD3. This fa
Autor:
R Garner, C D Helgason, E A Atkinson, M J Pinkoski, H L Ostergaard, O Sorensen, A Fu, P H Lapchak, A Rabinovitch, J E McElhaney
Publikováno v:
The Journal of Immunology. 153:5413-5421
The mechanism(s) by which CTL induce target cell lysis have not been clearly elucidated. Perforin and the cytotoxic cell proteinases (granzymes) contained within the granules of CTL and NK, have been implicated, but abundant evidence for the existenc
Autor:
Ian S. Trowbridge, H L Ostergaard
Publikováno v:
The Journal of Experimental Medicine
Antibody-mediated CD4 crosslinking results in increased tyrosine phosphorylation and tyrosine kinase activity of the associated p56lck. Treatment with anti-CD4 and anti-Ig also induced the phosphorylation of p56lck in a CD45- mutant cell line, indica
Autor:
J O, Ebinu, S L, Stang, C, Teixeira, D A, Bottorff, J, Hooton, P M, Blumberg, M, Barry, R C, Bleakley, H L, Ostergaard, J C, Stone
Publikováno v:
Blood. 95(10)
Stimulation of the T-cell receptor (TCR) alters a number of intracellular signaling pathways including one that involves protein tyrosine kinases, phospholipase C-gamma1 (PLC-gamma1), diacylglycerol (DAG), and calcium messengers. By a divergent pathw
Two distinct domains of the beta-subunit of glucosidase II interact with the catalytic alpha-subunit
Autor:
C W, Arendt, H L, Ostergaard
Publikováno v:
Glycobiology. 10(5)
Recent purification and cDNA cloning of the endoplasmic reticulum processing enzyme glucosidase II have revealed that it is composed of two soluble proteins: a catalytic alpha-subunit and a beta-subunit of unknown function, both of which are highly c
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(6)
Requirements for T cell activation are not fully established. One model is that receptor occupancy and down-regulation are essential for activation, and another, not necessarily mutually exclusive, model is that sustained signals are important. Here
Autor:
N N, Berg, H L, Ostergaard
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 159(4)
Stimulation through the TCR is known to induce tyrosine phosphorylation of a number of proteins, which leads to functional activation of T cells. Identification of the substrates that become phosphorylated and defining their interactions with other s
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 155(11)
CD45 is a transmembrane protein tyrosine phosphatase required for signal transduction through the Ag receptor complexes of T and B lymphocytes. Herein, we demonstrate that immobilized mAbs to the external domain of CD45 induce rapid and dramatic morp