Výsledky vyhledávání

Bioactivation of aromatic amines by recombinant human cytochrome P4501A2 expressed in Ames tester strain bacteria: a substitute for activation by mammalian tissue preparations

Autor: P D, Josephy, L S, DeBruin, H L, Lord, J N, Oak, D H, Evans, Z, Guo, M S, Dong, F P, Guengerich

Publikováno v: Cancer research. 55(4)

The most widely used bioassay in genetic toxicology is the Ames test, which combines a bacterial mutagenicity assay (reversion of Salmonella typhimurium histidine-auxotrophic tester strains) with an exogenous bioactivation system (hepatic postmitocho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30d811e327f3301131d0e83ed79abe3d
https://pubmed.ncbi.nlm.nih.gov/7850792

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Dimethylnitrosamine genotoxicity: does N-acetyltransferase activity play a role?

Autor: P D Josephy, Victor Snieckus, H L Lord

Publikováno v: Carcinogenesis. 15(3)

Dimethylnitrosamine (DMN) genotoxicity was evaluated in two test systems: induction of the umu operon (as measured by expression of a lacZ gene fusion) and mutagenicity (as measured by the Ames assay). Three Salmonella typhimurium strains were used;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e15d87ffe81f877df9dd0f5eba5892
https://pubmed.ncbi.nlm.nih.gov/8118932

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Salmonella typhimurium strains expressing human arylamine N-acetyltransferases: metabolism and mutagenic activation of aromatic amines

Autor: D M, Grant, P D, Josephy, H L, Lord, L D, Morrison

Publikováno v: Cancer research. 52(14)

Epidemiological studies have established the carcinogenic risk of occupational exposure to aromatic amines such as benzidine, beta-naphthylamine, and 4-aminobiphenyl. Metabolic activation of these chemicals to reactive, genotoxic electrophiles, via e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b41e83f5fdacf5fb6e23b38879e3ea7f
https://pubmed.ncbi.nlm.nih.gov/1617672

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Reevaluation of the effect of ellagic acid on N-methyl-N-nitrosourea DNA alkylation and mutagenicity

Autor: H L Lord, Victor Snieckus, P D Josephy

Publikováno v: Chemical research in toxicology. 3(3)

N-Methyl-N-nitrosourea (MNU) is a reactive, mutagenic methylating agent. MNU methylates DNA at various sites, including guanine N7, guanine O6, and adenine N3. Dixit and Gold [(1986) Proc. Natl. Acad. Sci. U.S.A. 83, 8039-8043] reported that ellagic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fc051d0285dc277f3d99e2517a8ed4
https://pubmed.ncbi.nlm.nih.gov/2131830

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Re-evaluation of the effect of ellagic acid on dimethylnitrosamine mutagenicity

Autor: H L Lord, P D Josephy, Victor Snieckus

Publikováno v: Mutagenesis. 4(6)

Dimethylnitrosamine (DMN) is activated to mutagenic species in the Ames test (Salmonella typhimurium strain TA100) by hamster hepatic S9 preparation. This S9 activity is induced by administration of ethanol to the animals. The organic solvents dimeth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fc4d510c43717ae143dd1aabbf1903
https://pubmed.ncbi.nlm.nih.gov/2695758

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