Zobrazeno 1 - 10
of 16
pro vyhledávání: '"H L, Liber"'
Publikováno v:
Cancer research. 59(13)
To explore further the possibility that some forms of mutated p53 may increase mutagenesis in a positive manner, a double p53 knockout cell line was created, using a promoterless gene targeting approach. The identity of these p53-null cells was confi
Publikováno v:
Radiation research. 147(2)
Previous work with two closely related human lymphoblast cell lines demonstrated that WTK1 cells are more resistant than TK6 cells to X-ray-induced cytotoxicity, but more mutable at both the TK and HPRT loci. It was subsequently determined that WTK1
Autor:
Y Y, Chuang, H L, Liber
Publikováno v:
Radiation research. 146(5)
Relatively little work has been done on the influence of the position of the cell in the cell cycle on ionizing radiation-induced mutagenesis. We synchronized WTK1 human lymphoblastoid cells with 200 microM lovastatin for 48 h; under these conditions
Publikováno v:
Radiation research. 143(3)
Previous work showed that WTK1 human lymphoblastoid cells are radioresistant but more sensitive to X-ray-induced mutation than the closely related line TK6. In addition, WTK1 cells contain a mutant p53 while in TK6 cells p53 is wild-type. In this wor
Autor:
F, Xia, H L, Liber
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 48
Publikováno v:
Cancer research. 55(1)
Previous work identified TK6 and WTK1 as human lymphoblast cell lines from one donor that have different capacities to catalyze recombination and that vary significantly in their response to ionizing radiation. WTK1 cells are more resistant to the to
Publikováno v:
Radiation research. 136(2)
Mutants at the hprt locus isolated after treatment of cells of the human lymphoblastoid cell line TK6 with X rays were examined by Northern blot and cDNA sequence analysis. In previous work, Southern blot analysis showed that approximately 25% of the
Autor:
C M, Denault, H L, Liber
Publikováno v:
Radiation research. 135(1)
The effects of cysteamine and hypoxia on X-ray-induced mutation in human lymphoblast cells have been investigated. Irradiation of these cells under these two sets of radioprotective conditions resulted in a fourfold lower mutant fraction at the hprt
Publikováno v:
Radiation research. 132(3)
The human lymphoblast cell line TK6 was exposed to the alpha-particle-emitting radon daughter 212Bi by adding DTPA-chelated 212Bi directly to the cell suspension. Cytotoxicity and mutagenicity at two genetic loci were measured, and the molecular natu
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1(7)
We previously reported that some Hodgkin's disease patients had elevated hprt mutant frequencies in peripheral blood lymphocytes long after cessation of therapy. To determine if these elevations in mutant frequency represent true persistently elevate