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Akademický článek
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Autor:
H L, Kong, R G, Crystal
Publikováno v:
JNCI Journal of the National Cancer Institute. 90:273-286
Based on the concept that solid tumors cannot grow without the generation of new blood vessels, there is growing interest in the use of antiangiogenesis agents to inhibit tumor growth. This review summarizes the concepts of using gene transfer vector
Autor:
Karil Abrahamsen, D Brough, H L Kong, A Lizonova, Andrea Mastrangeli, Erik Falck-Pedersen, Ronald G. Crystal
Publikováno v:
Journal of Virology. 71:8946-8951
A strategy for constructing replication-defective adenovirus vectors from non-subgroup C viruses has been successfully demonstrated with adenovirus type 7 strain a (Ad7a) as the prototype. An E1A-deleted Ad7a reporter virus expressing the chloramphen
Publikováno v:
Alimentary pharmacologytherapeutics. 16(11)
Chronic hepatitis B virus carriers receiving chemotherapy develop a high hepatitis B virus reactivation rate (38-53%) with a high mortality (37-60%). Few studies have characterized the efficacy of lamivudine in the treatment of chemotherapy-induced h
Publikováno v:
Pharmaceutical research. 18(6)
To develop a two-dimensional simulation platform for the transport of doxorubicin to the hepatoma. To examine the temporal and spatial variation of doxorubicin concentration and its penetration into the tumor and the surrounding normal tissues.Simula
Autor:
H L, Kong
Publikováno v:
Singapore medical journal. 40(3)
Autor:
H L, Kong
Publikováno v:
Annals of the Academy of Medicine, Singapore. 28(1)
The appropriate use of animal tumour models has a pivotal role in the evaluation of any new anti-cancer therapy. Indeed, animal models of human diseases have been emphasised in the early development and evaluation of gene therapy. Given that most can
Publikováno v:
Singapore medical journal. 37(6)
Haemolysis is an uncommon first manifestation of Wilson's disease. We describe a young woman who presented with episodic haemolysis and abnormal liver functions; the diagnosis of Wilson's disease was not made until nine months later. She responded we
Publikováno v:
Singapore medical journal. 33(5)
We report a 54-year-old Chinese man with Cushing's syndrome from bilateral adrenal adenomata in whom surgery was contraindicated because of his intercurrent medical conditions. Instead, he was successfully treated with aminoglutethimide 0.75 gm/day (