Zobrazeno 1 - 3
of 3
pro vyhledávání: '"H L, Glansbeek"'
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 78(2)
A severe consequence of rheumatoid arthritis is depletion of proteoglycans (PGs) from articular cartilage leading to functional impairment of this tissue. We investigated whether local administration of anabolic factors (transforming growth factors-b
Publikováno v:
The Journal of rheumatology. 24(3)
To elucidate the role of transforming growth factor-beta (TGF-beta) and the small proteoglycans biglycan and decorin in the repair of articular cartilage after proteoglycan depletion.Limited and reversible proteoglycan depletion was induced by inject
Publikováno v:
Agents and actions. Supplements. 39
TGF-beta inhibits the proteoglycan synthesis of freshly isolated articular chondrocytes while TGF-beta stimulates the proteoglycan synthesis of articular chondrocytes cultured for 14 days. To investigate if this differential effect was the result of