Zobrazeno 1 - 10
of 139
pro vyhledávání: '"H L, Bradlow"'
Autor:
B. Zumoff, Deborah Axelrod, H. L. Bradlow, K. Frenkel, R. B. Alvarez-Vasquez, M. C. Newman, D. W. Sepkovic
Publikováno v:
Hormone and Metabolic Research. 35:358-361
Whether postmenopausal hormone-replacement therapy (HRT) increases the risk of breast cancer remains controversial, despite numerous epidemiological studies. We approached the question from a biochemical rather than an epidemiological direction - we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ca648c2dfb0121f16440ad828f91b2e
https://doi.org/10.1055/s-2003-41357
https://doi.org/10.1055/s-2003-41357
Publikováno v:
Carcinogenesis. 24:991-1005
Studies of circulating estrogen levels in relation to pre-menopausal breast cancer risk have yielded inconsistent results. Various estrogen metabolites might affect the risk differently. Estradiol metabolism occurs primarily via two mutually exclusiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b207fae6323cd7e8fda86a216d2447c3
https://doi.org/10.1093/carcin/bgg047
https://doi.org/10.1093/carcin/bgg047
Publikováno v:
Nutrition and Cancer. 41:57-63
Indole-3-carbinol (I3C) or, more correctly, its acid condensation products act as chemoprotective agents via several mechanisms. It induces the expression of cytochrome P-450 1A1, which shifts the estrogen metabolic pathway in favor of C-2 hydroxylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df24351478a6283d194ad3cd1bb3615b
https://doi.org/10.1080/01635581.2001.9680612
https://doi.org/10.1080/01635581.2001.9680612
Autor:
Andrea Micheli, Daniel W. Sepkovic, Vittorio Krogh, Holger J. Schünemann, Jun Yang, Martin Stanulla, H. L. Bradlow, Jo L. Freudenheim, Maurizio Trevisan, Paola Muti, Franco Berrino
Publikováno v:
Epidemiology. 11:635-640
Experimental and clinical evidence suggests that 16alpha-hydroxylated estrogen metabolites, biologically strong estrogens, are associated with breast cancer risk, while 2-hydroxylated metabolites, with lower estrogenic activity, are weakly related to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95cdc817b225262765dff9203c2011b0
https://doi.org/10.1097/00001648-200011000-00004
https://doi.org/10.1097/00001648-200011000-00004
Autor:
Seymour Garte, H. L. Bradlow, Osborne Mp, Trachman J, Emanuela Taioli, Daniel W. Sepkovic, Samantha Garbers, Ganguly S
Publikováno v:
Cancer Detection Prevention. 23:232-237
The endogenous metabolism of estrogens is primarily oxidative and involves hydroxylation of the steroid at either C2 (2-OHE1) or C16 (16-OHE1). While the 2-OHE1 metabolites are essentially devoid of peripheral biological activity, 16-OHE1 is an estro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09faa2f2111e0ec6f9097443c4da0058
https://doi.org/10.1046/j.1525-1500.1999.09912.x
https://doi.org/10.1046/j.1525-1500.1999.09912.x
Publikováno v:
Journal of Lipid Research, Vol 19, Iss 7, Pp 850-855 (1978)
In order to devise a convenient method for measuring the rate of formation of bile acids from cholesterol in man, [24,25-3H] cholesterol was prepared by catalytic tritiation of desmosterol where the delta5-unsaturation was protected by conversion to
Externí odkaz:
https://doaj.org/article/a0e04a710d0641e095d5aa1f6e2e11b7
Publikováno v:
Journal of Lipid Research, Vol 27, Iss 2, Pp 183-195 (1986)
Bile acid production has been quantitated in seven subjects by methods that compare the results of two independent approaches, namely, quantitation of cholesterol side-chain oxidation and fecal bile acid excretion. Six hypertriglyceridemic (HT) subje
Externí odkaz:
https://doaj.org/article/68c3c148d1f54d50b38320f1911b1a7d
Autor:
Orazia M. Granata, Michael P. Osborne, F. Arcuri, Luigi Castagnetta, H. L. Bradlow, Nitin T. Telang
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
Scopus-Elsevier
Targeted overexpression of the c-myc oncogene induces neoplastic transformation in immortalized, non-tumorigenic mouse mammary epithelial cells (MMEC). Experiments in the present study were conducted to examine whether cellular transformation induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffad473a6b9cb42e139f02c5e2045e7
https://doi.org/10.1038/bjc.1998.255
https://doi.org/10.1038/bjc.1998.255
Publikováno v:
Scopus-Elsevier
Increased 16alpha-hydroxylation of estradiol has been shown to be associated with heightened cancer risk in estrogen responsive tissue. Certain types of human papillomavirus (HPV) are cofactors for cancer in the cervix, an estrogen sensitive tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3923d8006cb92cc5c1684ec8dce929
https://doi.org/10.3181/00379727-217-44239
https://doi.org/10.3181/00379727-217-44239