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Publikováno v: Therapies. 59:323-328

The round table elected to focus its discussion on trials that, in terms of their importance, are likely to modify medical practices and behaviour. Such trials may be pre- or postmarketing studies. For the findings of a trial to result in a change in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bdafdfab1745bbb29bf6a7a6c4bb6ae
https://doi.org/10.2515/therapie:2004061

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Public Information about Clinical Trials and Research

Publikováno v: Therapies. 58:197-208

Be it to restore the confused image of clinical research in relation to the lay public, or to develop new ways of accruing healthy volunteers or patients for clinical trials, there is a need to draft some guidance on how best to provide information o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abf0a25a1a812cbc97c8727395f32631
https://doi.org/10.2515/therapie:2003032

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Can anaerobic threshold be used as an end-point for therapeutic trials in heart failure?

Autor: P Gueret, J F Aupetit, Faiez Zannad, H Kolsky, Alain Cohen-Solal

Publikováno v: European Heart Journal. 15:236-241

Anaerobic threshold (AT), proposed as a non-invasive index of exercise tolerance, independent of patient motivation, is considered more reliable than exercise duration in assessing the effect of drug therapy in chronic heart failure (CHF). However, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da7c8542ccf0fd8c55472d8abbd30a38
https://doi.org/10.1093/oxfordjournals.eurheartj.a060482

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Hemodynamics, Tolerability, and Pharmacokinetics of Linsidomine (SIN-1) Infusion During the Acute Phase of Uncomplicated Myocardial Infarction

Autor: A Foucher-Lavergne, Ph Beaufils, H. Kolsky, O Spreux-Varoquaux, J Delonca

Publikováno v: Journal of Cardiovascular Pharmacology. 22:779-784

To determine a dose regimen and evaluate the hemodynamic effects of linsidomine administered by continuous intravenous (i.v.) infusion, 10 patients were studied during the acute phase of uncomplicated myocardial infarction (MI). Systolic, diastolic,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3824db1ee9ae5f83dc2663babcf7acf6
https://doi.org/10.1097/00005344-199312000-00001

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Gastroduodenal tolerability of medium dose enteric-coated aspirin: a placebo controlled endoscopic study of a new enteric-coated formulation versus regular formulation in healthy volunteers

Autor: I Mahé, H Kolsky, A Deverly, J F Bergmann, J P Barbier, H Blondon

Publikováno v: Fundamental & Clinical Pharmacology. 14:155-157

We compared, in a cross-over study, the toxicity of 300 mg enteric-coated aspirin with regular aspirin used for the prevention of cardiovascular events. In terms of endoscopic haemorrhagic lesions, enteric-coated aspirin is less gastrotoxic than regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b77d7fb291a0aa64b7d7c04e18744a
https://doi.org/10.1111/j.1472-8206.2000.tb00404.x

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Multicentre study of the determination of peak oxygen uptake and ventilatory threshold during bicycle exercise in chronic heart failure

Autor: H Kolsky, J G Kayanakis, J F Aupetit, Faiez Zannad, Alain Cohen-Solal, P Gueret

Publikováno v: European Heart Journal. 12:1055-1063

Assessment of the ventilatory threshold (VT) has been proposed to assess exercise tolerance more objectively, particularly in clinical trials, but reproducibility, interobserver variability and feasibility of the graphical methods for determination o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bdf486596dd7c64df51870dbd35d40e
https://doi.org/10.1093/oxfordjournals.eurheartj.a059837

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[Characteristics of a cohort of 4,000 French patients with angina. The ELAN study]

Autor: L, Guize, P, Ducimetière, S M, Consoli, H, Kolsky, P, Raynaud, J M, Walch, A, Paul-Dauphin, I, Duprat-Lomon

Publikováno v: Archives des maladies du coeur et des vaisseaux. 93(3)

The ELAN (Etude Longitudinale dans l'ANgor) study was carried out to evaluate factors influencing the occurrence of death, myocardial infarction and revascularization procedures in patients with known angina pectoris. Analysis of baseline data collec

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https://pubmed.ncbi.nlm.nih.gov/11004967

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[One-year follow-up of a population of patients with angina. Factors influencing mortality and occurrence of cardiovascular events. Results of the ELAN study]

Autor: L, Guize, P, Ducimetière, S M, Consoli, H, Kolsky, P, Raynaud, J M, Walch, A, Paul-Dauphin, I, Duprat-Lomon

Publikováno v: Archives des maladies du coeur et des vaisseaux. 93(3)

The ELAN (Etude longitudinale dans l'angor) study was carried out both to acquire better knowledge of the occurrence of major cardiovascular events (myocardial infarction, revascularization surgery, death) in patients followed up for angina pectoris,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7492c0c3bdc2621e825cf51980f2592a
https://pubmed.ncbi.nlm.nih.gov/11004968

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Can anaerobic threshold be used as an end-point for therapeutic trials in heart failure? Lessons from a multicentre randomized placebo-controlled trial. The VO2 French Study Group

Autor: A, Cohen-Solal, J F, Aupetit, P, Gueret, H, Kolsky, F, Zannad

Publikováno v: European heart journal. 15(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d4298a437165914b74849e4098ec672c
https://pubmed.ncbi.nlm.nih.gov/8005126

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