Zobrazeno 1 - 10
of 646
pro vyhledávání: '"H Kok"'
Autor:
Mihir D. Wechalekar, Lin-Pierre Zhao, Monika M. Kutyna, Lih En Hong, Joule Li, Kevin Hung, Hamish S. Scott, Anna Brown, Christopher C. Hahn, Karin Kassahn, Dariusz Ladon, David T. Yeung, Daniel Thomas, Mrinal Patnaik, Susanna Proudman, Lionel Ades, Mithun V. Shah, Chung H. Kok, Devendra K. Hiwase
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/8a363b1a155c4c5b8cf3f98ef635b878
Autor:
Chung H. Kok, Verity A. Saunders, Phuong Dang, Naranie Shanmuganathan, Deborah White, Susan Branford, David Yeung, Timothy P. Hughes
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Variability in the molecular response to frontline tyrosine kinase inhibitor (TKI) therapy in chronic myeloid leukemia may be partially driven by differences in the level of kinase inhibition induced. We measured in vivo BCR::ABL1 kinase inh
Externí odkaz:
https://doaj.org/article/d6731b0c86394c2e83b0f1889d8f076d
Autor:
Benjamin C. S. Leow, Chung H. Kok, David T. Yeung, Timothy P. Hughes, Deborah L. White, Laura N. Eadie
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract In Chronic Myeloid Leukemia, the transition from drug sensitive to drug resistant disease is poorly understood. Here, we used exploratory sequencing of gene transcripts to determine the mechanisms of drug resistance in a dasatinib resistant
Externí odkaz:
https://doaj.org/article/e5ec46d7ff8f4e43a4e9a2c6a3fe195d
Autor:
Per Borghammer, Mie Kristine Just, Jacob Horsager, Casper Skjærbæk, Anna Raunio, Eloise H. Kok, Sara Savola, Shigeo Murayama, Yuko Saito, Liisa Myllykangas, Nathalie Van Den Berge
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract The dual-hit hypothesis of Parkinson’s disease (PD) originally postulated that a neurotropic pathogen leads to formation of α-synuclein pathology in the olfactory bulb (OB) and dorsal motor nucleus of the vagus (DMV) and then invades the
Externí odkaz:
https://doaj.org/article/23baeb5a880245f5a53d389e0b383104
Autor:
Gerald A. Hebbink, Pauline H. M. Janssen, Jurjen H. Kok, Lorenzo Menarini, Federica Giatti, Caterina Funaro, Salvatore Fabrizio Consoli, Bastiaan H. J. Dickhoff
Publikováno v:
Pharmaceutics, Vol 15, Iss 11, p 2575 (2023)
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control. Compared to batch blending, c
Externí odkaz:
https://doaj.org/article/cec59121470c455ca55a7b1e7f2fb005
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/c06f9165d2d145a4a7c1a1328970f8ab
Autor:
Yazad D. Irani, Chung H. Kok, Jade Clarson, Naranie Shanmuganathan, Susan Branford, David T. Yeung, David M. Ross, Timothy P. Hughes, Agnes S. M. Yong
Publikováno v:
Blood Advances. 7:2364-2374
Dysregulation of immune-checkpoint receptors has been reported at diagnosis of chronic myeloid leukemia (CML), however, their role in the maintenance of remission after tyrosine kinase inhibitor (TKI) cessation is unclear. We assessed programmed cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::863ea30bd050ebfe93a90f31baaa89cd
https://doi.org/10.1182/bloodadvances.2022008854
https://doi.org/10.1182/bloodadvances.2022008854
Autor:
Marc García-Montolio, Cecilia Ballaré, Enrique Blanco, Arantxa Gutiérrez, Sergi Aranda, Antonio Gómez, Chung H. Kok, David T. Yeung, Timothy P. Hughes, Pedro Vizán, Luciano Di Croce
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Polycomb group (PcG) of proteins are a group of highly conserved epigenetic regulators involved in many biological functions, such as embryonic development, cell proliferation, and adult stem cell determination. PHD finger protein 19 (PHF19) is an as
Externí odkaz:
https://doaj.org/article/26af3eba155649eea25f4e22142fbec5
Autor:
Pauline H M, Janssen, Alberto, Berardi, Jurjen H, Kok, Anthony W, Thornton, Bastiaan H J, Dickhoff
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics, 180, 251-259. ELSEVIER SCIENCE BV
Besides factors such as disintegrant and lubricant, the raw material properties of filler excipients can have an impact on the disintegration behavior of a tablet. The current research aims to model the impact of lactose properties on disintegration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd74c4c40046ef0f1a87cbb1fef3cbc7
https://hdl.handle.net/11370/55fcdd77-0c96-4c06-9052-c2f36ed86ff2
https://hdl.handle.net/11370/55fcdd77-0c96-4c06-9052-c2f36ed86ff2
Autor:
D. A. Casolari, T. Nguyen, C. M. Butcher, D. G. Iarossi, C. N. Hahn, S. C. Bray, P. Neufing, W. T. Parker, J. Feng, K. Z. Y. Maung, A. Wee, L. Vidovic, C. H. Kok, P. G. Bardy, S. Branford, I. D. Lewis, S. W. Lane, H. S. Scott, D. M. Ross, R. J. D’Andrea
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract We describe a novel ERBB1/EGFR somatic mutation (p. C329R; c.985 T > C) identified in a patient with JAK2V617F Polycythaemia Vera (PV). This substitution affects a conserved cysteine residue in EGFR domain 2 and leads to the formation of a l
Externí odkaz:
https://doaj.org/article/b3f3e98ac3f74378a5acf9fa8bc21d11