Zobrazeno 1 - 10
of 125
pro vyhledávání: '"H Kirk Hammond"'
Autor:
Young Song, Joseph Leem, Mehul Dhanani, M Dan McKirnan, Yasuhiro Ichikawa, Julie Braza, Elizabeth O Harrington, H Kirk Hammond, David M Roth, Hemal H Patel
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0281550 (2023)
Role of blood-based factors in development and progression of heart failure (HF) is poorly characterized. Blood contains factors released during pathophysiological states that may impact cellular function and provide mechanistic insights to HF manage
Externí odkaz:
https://doaj.org/article/72a857b7ce3f4c92a22888e4870cf155
Autor:
Young Chul Kim, Agnieszka D Truax, Dimosthenis Giamouridis, N Chin Lai, Tracy Guo, H Kirk Hammond, Mei Hua Gao
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0224428 (2019)
IntroductionUrocortin 2 (Ucn2) is a 38-amino acid peptide of the corticotropin-releasing factor family. Intravenous (IV) delivery of an adeno-associated virus vector serotype 8 encoding Ucn2 (AAV8.Ucn2) increases insulin sensitivity and glucose dispo
Externí odkaz:
https://doaj.org/article/a76d1ce9339e432589e71472f8999c89
Autor:
Caroline Bull Melsom, Marie-Victoire Cosson, Øivind Ørstavik, Ngai Chin Lai, H Kirk Hammond, Jan-Bjørn Osnes, Tor Skomedal, Viacheslav Nikolaev, Finn Olav Levy, Kurt Allen Krobert
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218110 (2019)
PurposeWe previously reported that inhibitory G protein (Gi) exerts intrinsic receptor-independent inhibitory activity upon adenylyl cyclase (AC) that regulates contractile force in rat ventricle. The two major subtypes of AC in the heart are AC5 and
Externí odkaz:
https://doaj.org/article/79ca3f0a931a43d6af8fdd3172083fc6
Autor:
Yasuhiro Ichikawa, Alice E Zemljic-Harpf, Zheng Zhang, M Dan McKirnan, Ana Maria Manso, Robert S Ross, H Kirk Hammond, Hemal H Patel, David M Roth
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177660 (2017)
Anthracyclines are chemotherapeutic drugs known to induce heart failure in a dose-dependent manner. Mechanisms involved in anthracycline cardiotoxicity are an area of relevant investigation. Caveolins bind, organize and regulate receptors and signali
Externí odkaz:
https://doaj.org/article/785157a1d7cc406e9698745e0dd63ed3
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0181282 (2017)
Increased expression of adenylyl cyclase type 6 (AC6) has beneficial effects on the heart through cyclic adenosine monophosphate (cAMP)-dependent and cAMP-independent pathways. We previously generated a catalytically inactive mutant of AC6 (AC6mut) t
Externí odkaz:
https://doaj.org/article/a04ae54f71fd4853b07adb6d4178d6d9
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161536 (2016)
Methods commonly used clinically to assess cardiac function in patients with heart failure include ejection fraction (EF), exercise treadmill testing (ETT), and symptom evaluation. Although these approaches are useful in evaluating patients with hear
Externí odkaz:
https://doaj.org/article/c23badb4a5e440369a12873708eeaac4
Autor:
Mei Hua Gao, Ngai Chin Lai, Tong Tang, Tracy Guo, Ruoying Tang, Byeong Jo Chun, Hong Wang, Nancy N Dalton, Jorge Suarez, Wolfgang H Dillmann, H Kirk Hammond
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72151 (2013)
So many clinical trials of positive inotropes have failed, that it is now axiomatic that agents that increase cAMP are deleterious to the failing heart. An alternative strategy is to alter myocardial Ca(2+) handling or myofilament response to Ca(2+)
Externí odkaz:
https://doaj.org/article/76ec15caafda425fa06285823978e134
Publikováno v:
Human Gene Therapy. 33:1091-1100
We used transverse aortic constriction (TAC) in mice to test the hypothesis thatiurocortin 2/i(iUcn2/i) gene transfer would increase left ventricular (LV) systolic and diastolic function in the pressure-stressed LV. Three groups were studied: (1) con
Autor:
Mei Hua Gao, Dimosthenis Giamouridis, H. Kirk Hammond, Young Chul Kim, N. Chin Lai, Raag Bhargava, Dorota Skowronska-Krawczyk, Bing Xia, Tracy Guo, Louise Lantier, Viet Anh Nguyen Huu
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 220-233 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Type 1 diabetes affects 20 million patients worldwide. Insulin is the primary and commonly the sole therapy for type 1 diabetes. However, only a minority of patients attain the targeted glucose control and reduced adverse events. We tested urocortin
Autor:
Young Chul Kim, N. Chin Lai, Tracy Guo, Bing Xia, Zhenxing Fu, Mei Hua Gao, Dimosthenis Giamouridis, H. Kirk Hammond
Publikováno v:
Hum Gene Ther
Diabetes mellitus is associated with increased risk of heart failure. It has been previously demonstrated in mice that a single injection of adeno-associated virus 8 encoding urocortin 2 (AAV8.UCn2) increases glucose disposal in models of insulin res