Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial

Autor: Erin A Bohula, Benjamin M Scirica, Silvio E Inzucchi, Darren K McGuire, Anthony C Keech, Steven R Smith, Estella Kanevsky, Sabina A Murphy, Lawrence A Leiter, Jamie P Dwyer, Ramon Corbalan, Christian Hamm, Lee Kaplan, Jose Carlos Nicolau, Ton Oude Ophuis, Kausik K Ray, Mikhail Ruda, Jindrich Spinar, Tushar Patel, Wenfeng Miao, Carlos Perdomo, Bruce Francis, Shobha Dhadda, Marc P Bonaca, Christian T Ruff, Marc S Sabatine, Stephen D Wiviott, Silvio Inzucchi, Anthony Keech, Andrew Satlin, Conville Brown, Andrzej Budaj, Jamie Dwyer, Armando Garcia-Castillo, Milan Gupta, Kauski Ray, Neil Weissman, Harvey D White, J Amerena, M Arstall, D Colquhoun, R Jayasinghe, A Lee, R Lehman, R Moses, J Proietto, P Purnell, J Waites, P Blombery, D Cross, M Worthley, M d'Emden, J Selvanayagam, RE Oqueli, A Whelan, P Garrahy, F de Looze, D Ninio, J Horowitz, M William, M Suranyi, G Wittert, M Le May, AS Pandey, S Vizel, R Labonte, Y Beaudry, C Fortin, A Bell, S Kouz, É St-Amour, I Bata, F St Maurice, R Chehayeb, C Constance, G Wong, A Hess, J Liutkus, P Poirier, I Teitelbaum, J Berlingieri, J Cha, M Hartleib, M Heffernan, D Twum-Barima, V Pandith, R Aronson, R Goldenberg, B Ajala, A Jain, S Ross, H Bajaj, H Khandwala, Z Yared, N Gupta, J Bédard, S Wharton, F Blouin, D Savard, D Shukla, J Cobos, G Godoy, L Perez, C Pincetti, V Saavedra Guajardo, P Varleta, C Conejeros, F Lanas, E Bayram Llamas, E Cardona Muñoz, R Garcia, J Garza Ruiz, G Llamas Esperon, E Lopez Rosas, G Melendez Mier, G Ramos, H Hart, D Scott, I Ternouth, J Benatar, J Elliott, R Cutfield, P Manning, M Williams, K Ferrier, R Scott, S Wilson, R Leikis, BK Nirmalaraj, E Krzyżagórska, P Miękus, M Bronisz, E Mirek-Bryniarska, K Łanda, A Stasiewski, T Żechowicz, D Zytkiewicz-Jaruga, J Korecki, M Ogórek, L Pawłowicz, M Piepiorka, J Skierkowska, A Stankiewicz, E Szyprowska, R Witek, A Bochenek, P Kończakowski, Ł Wojnowski, M Wujkowski, K Cymerman, R Korzeniak, P Mąder, B Mikłaszewicz, P Stachlewski, A Goch, W Pomiećko, M Skórski, L Romanowski, K Jusiak, E Laskowska-Derlaga, R Bijata-Bronisz, J Kaźmierczak, R Goldberg, D Henderson, E Korban, K Rohr, E Claxton, R Weiss, D Angiolillo, F Boccalandro, K Chu, E Thorn, P Randhawa, N Singh, G Bittar, T Guarnieri, S Saeed, S Sharma, M Shepard, W French, P Desai, R Bernstein, W Rogers, R Singal, R Schneider, J Shanes, S Ong, J Condit, S Donahoe, D Brill, D Einhorn, R Ebrahimi, A Labroo, R Graf, J Scott, J Hoekstra, P Jetty, G Luckasen, P O'Donnell, W Gonte, D Pomposini, M Quadrel, M Koren, D Schlager, E Schramm, D Singal, S Lupovitch, A Soni, P Seigel, J Roberts, J Soufer, S Reza, E Quinlan, T Moretto, B First, M Khan, S Chilka, H Colfer, A Teklinski, K Wallace-Wilding, H Ellison, D Muse, S Aronoff, A Higgins, S Patel, V Elinoff, A Karim, V Awasty, R Chuang, H Roseman, P Dugano-Daphnis, M Albert, K Sheikh, H Bays, S Kaster, M Goldstein, D Rubino, G Calatayud, H Snyder, T Williams, K Hershon, M Hagan, S Isserman, B Kahn, J Anderson, MP Gimness, A Raisinghani, M Christina, M Raikhel, E Gillespie, E Portnay, M Heiman, M Qureshi, J Lee, R Blonder, F Cucher, G Miller, D Kotlaba, G Cornett, J Beavins, C Augenbraun, S Reinhardt, A Bartkowiak, A Salacata, T Blevins, S Benjamin, J Diener, W George, B Barker, R Richwine, D Baldari, A Alfieri, A Barreto, L Zhang, R Shah, E Hendrix, V Subramaniyam, S Hurley, M Lillestol, M O'Donoghue, S Shayani, E Ryan, R Call, L Zemel, A Chang, A Kivitz, B Freyne, V Bland, K Shore, E Mostel, E Uzoaga, N Andrawis, N Gabra, A Ghitis, K Sabatino, D Browder, S Varma, S Smith, R Fink, GR Aycock, WD Doty, T Alfonso, S Eshaghian, R Karlsberg, S Zarich, C Landau, M McKenzie, R Krause, W Davis, T Haddad, S Voyce, C Alford, J LeDoux, D O'Dea, J Park, V Aroda, A Getaneh, B Graham, R Bhagwat, D Korn, G Ruoff, A Wiseman, I Lieber, J Fialkow, JM Gonzalez-Campoy, C Bayron, B Bertolet, J Lash, C Gerrish, D Robertson, J Rosenfeld, M Seidner, J Agaiby, J Silverfield, D Sugimoto, B Lubin, M Alhaddad, H Lui, G Lakin, S Chokshi, D Donovan, W Felten, S Minton, C Kimmelstiel, J Kuvin, C Still, W Byars, J Talano, V Desai, AJ Bradley, S Baker, M Chane, A Mercado, S Baron, B Harris, N Mayer, M Concha, K Carr, L Chaykin, J Willis, A Clay, E Fenstad, J Furda, P Peterson, M Chang, L Aronne, D Jones, R Prashad, M Benson, R Stegemoller, K Longshaw, J Saleh, W Jennings, R Detweiler, D Viswanath, R Patel, S Lederman, D Weinstein, R Korabathina, V Singh, J Rosen, R Estevez, P Levin, R McNeill, V Kalen, J Reed, R Ashley, L Herman, Y Tsai, D Kayne, A White, I Hussain, L Tami, K Cohen, J Robinson, D Fuchs-Ertman, G Platt, L Belardo, R Reddy, C Rosendorff, F Saba, S Powell, K Anderson, M Abidi, S Rezkalla, A Paraschos, J Wilson, M Moursi, A Shah, V Nadar, L Stonesifer, M Bialow, K Cannon, W Ellison, M Stedman, J Brown, W Harper, KJ Lucas, M DiGiovanna, H Rodbard, M Biscoveanu, C Davis, J Hall, R Littlefield, T Gorman, D Kereiakes, FM Chang, H Tatu, D Cheung, J Kaine, T Knutson, T Logemann, G Pueblitz, J Bianco, B Henson, M Neustel, M Gelernt, W Nelson, K Moriarty, G Lefebvre, K Maw, L Rink, P Behn, H Studdard, G Argoud, T O'Connor, P Krichmar, G Raad, J Pereles-Ortiz, C Sorli, A Cohen, K Pettis, B Cavanaugh, C Phillips, J Wahlen, D Radin, J Rider, E Kosinski, W Leimbach, A Odhav, J Hakas, A Tan, M Howell, D Wombolt, N Fishman, P Shah, P Wylie, C Arauz-Pacheco, A Cavale, A George, R Kroll, J Krantzler, N Tahirkheli, M Jabro, M Newell, P Mullen, N Gencheff, J Meli, K Vora, L Kotek, K Pyzdrowski, H Paez, J Moran, A Tannenbaum, K Deck, R Busch, L Levinson, M Azizad, J Whitaker, B Fox, C Huffman, M Ashraf, J Diogo, R Kushner, J Tallet, V Channamsetty, D Suh, M Atieh, J Navas, V Young, S Shaw, I Dor, B Duffy, P Rubin, D Lewis, W Kaye, R Benton, J Burbano, D Hotchkiss, A Magno, A Alberton, J Collins, O Alvarado, M Stich, S Mahal, J Liu, M Hong, J Dy, B Block, J Lamantia, J Pritchard, M Davis, S Srivastava, S Bilazarian, R Rosario, M McCartney, V Blumberg, R Rajan, E Martin, S Wright, C Brinson, J Johnston, M Graves, M Dominguez, W McKenzie, R Abadier, C Tran, R Castello, E Morawski, J White, F Morris, A Perez, P Trueba, M Sanchez, J Andersen, R Kastelic, J Khan, H Rodriguez, W Izquierdo, A Matias, L Essandoh, C Ince

Publikováno v: Lancet (London, England). 392(10161)

BACKGROUND: There is a direct relationship between bodyweight and risk of diabetes. Lorcaserin, a selective serotonin 2C receptor agonist that suppresses appetite, has been shown to facilitate sustained weight loss in obese or overweight patients. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a4e189e200fa6beb5d4585cfb676ca
https://pubmed.ncbi.nlm.nih.gov/30740430

Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis

Autor: C W, Loomis, H, Khandwala, G, Osmond, M P, Hefferan

Publikováno v: The Journal of pharmacology and experimental therapeutics. 296(3)

Tactile allodynia can be modeled in experimental animals by acutely blocking spinal glycine or GABA(A) receptors with intrathecal (i.t.) strychnine (STR) or bicuculline (BIC), respectively. To test the hypothesis that glycine and GABA effect cooperat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::99dd1a1844f682c6d080f63437b4f9ab
https://pubmed.ncbi.nlm.nih.gov/11181903

IMpact of flash glucose Monitoring in pEople with type 2 Diabetes Inadequately controlled with non-insulin Antihyperglycaemic ThErapy (IMMEDIATE): A randomized controlled trial.

Autor: Aronson R; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Brown RE; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Chu L; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Bajaj HS; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Khandwala H; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Abitbol A; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Malakieh N; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Goldenberg R; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada.

Publikováno v: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 Apr; Vol. 25 (4), pp. 1024-1031. Date of Electronic Publication: 2023 Jan 11.

Goal achievement of HbA1c and LDL-cholesterol in a randomized trial comparing colesevelam with ezetimibe: GOAL-RCT.

Autor: Bajaj HS; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada.; Leadership Sinai Center for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada., Brown RE; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Jiandani D; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Venn K; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Al-Asaad H; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Khandwala H; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Steen O; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Abdel-Salam S; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada., Aronson R; LMC Diabetes & Endocrinology, Toronto, Ontario, Canada.

Publikováno v: Diabetes, obesity & metabolism [Diabetes Obes Metab] 2020 Oct; Vol. 22 (10), pp. 1722-1728. Date of Electronic Publication: 2020 Jun 18.

Diabetes Canada Position Statement for People With Types 1 and 2 Diabetes Who Fast During Ramadan.

Autor: Bajaj HS; LMC Diabetes & Endocrinology, Brampton, Ontario, Canada; Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada; STOP Diabetes Foundation, Brampton, Ontario, Canada. Electronic address: harpreet.bajaj@lmc.ca., Abouhassan T; Schulich School of Medicine and Dentistry, Windsor, Ontario, Canada; Erie-St. Clair LHIN 1 Diabetes Lead, Windsor, Ontario, Canada., Ahsan MR; Division of Cardiac Surgery, St Michael's Hospital, Toronto, Ontario, Canada., Arnaout A; University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada; Division of Endocrinology and Metabolism, The Ottawa Hospital, Ottawa, Ontario, Canada., Hassanein M; Endocrinology, Dubai Hospital, Dubai Health Authority, Dubai, United Arab Emirates; Postgraduate Diabetes Education, Cardiff University, Cardiff, United Kingdom; Diabetes and Ramadan International Alliance., Houlden RL; Division of Endocrinology, Queen's University, Kingston, Ontario, Canada., Khan T; STOP Diabetes Foundation, Brampton, Ontario, Canada; LMC Diabetes & Endocrinology, Oakville, Ontario, Canada; Harvard T. H. Chan School of Public Health, Harvard University, Cambridge, Massachusetts, United States., Khandwala H; LMC Diabetes & Endocrinology, Etobicoke, Ontario, Canada., Verma S; Division of Cardiac Surgery, St Michael's Hospital, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, Ontario, Canada.

Publikováno v: Canadian journal of diabetes [Can J Diabetes] 2019 Feb; Vol. 43 (1), pp. 3-12. Date of Electronic Publication: 2018 Apr 27.