Zobrazeno 1 - 10 of 13 pro vyhledávání: '"H K Spencer"'
2
New 1-(heterocyclylalkyl)-4-(propionanilido)-4-piperidinyl methyl ester and methylene methyl ether analgesics
Autor: J. R. Bagley, Theodore C. Spaulding, B. M. Doorley, S A Thomas, Michael H. Ossipov, Frieda G. Rudo, H. K. Spencer, Mark J. Benvenga, T. P. Jerussi
Publikováno v: Journal of Medicinal Chemistry. 34:827-841
A series of new 1-(heterocyclyalkyl)-4-(propionanilido)-4-piperidinyl methyl esters and methylene methyl ethers have been synthesized and pharmacologically evaluated. In the mouse hot-plate test, the majority of compounds exhibited an analgesia (ED50
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b2488784bafa855e397dd63e2b3563
https://doi.org/10.1021/jm00106a051
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3
Synthesis and pharmacological evaluation of a series of new 3-methyl-1,4-disubstituted-piperidine analgesics
Autor: N, Lalinde, J, Moliterni, D, Wright, H K, Spencer, M H, Ossipov, T C, Spaulding, F G, Rudo
Publikováno v: Journal of medicinal chemistry. 33(10)
The synthesis and intravenous analgesic activity of a series of 3-methyl-4-(N-phenyl amido)piperidines, entries 34-79, is described. The methoxyacetamide pharmacophore produced a series of compounds with optimal analgesic potency and short duration o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3bf85374972f0bfee284a332a5940512
https://pubmed.ncbi.nlm.nih.gov/2170652
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6
New 4-(heteroanilido)piperidines, structurally related to the pure opioidagonist fentanyl, with agonist and/or antagonist properties
Autor: B. M. Doorley, J. R. Bagley, Frieda G. Rudo, H. K. Spencer, Theodore C. Spaulding, R. L. Wynn
Publikováno v: Journal of Medicinal Chemistry. 32:663-671
A research program based on certain heterocyclic modifications (12-50) of the fentanyl (1) molecule has generated a novel class of opioids. In the mouse hot-plate test, these compounds were weaker analgesics than 1. Two types of antagonists were obse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9dfa6e13dd177be45ef1443d649851
https://doi.org/10.1021/jm00123a028
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7
Synthesis and pharmacological evaluation of 4,4-disubstituted piperidines
Autor: Diamantidis G, J. A. Colapret, Theodore C. Spaulding, Frieda G. Rudo, H. K. Spencer
Publikováno v: Journal of medicinal chemistry. 32(5)
A new class of piperidine derivatives is added to the increasing family of compounds related to fentanyl and carfentanil. Herein, we describe the synthesis and pharmacology of a number of 1-(arylethyl)-4-(acylamino)-4-[(acyloxy)-methyl]piperidines su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb464eeaabc7257169cc05cd27b6c6cf
https://pubmed.ncbi.nlm.nih.gov/2709383
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