Zobrazeno 1 - 10
of 147
pro vyhledávání: '"H Joseph Yost"'
Autor:
Maria de Los Angeles Serrano, Bradley L Demarest, Tarlynn Tone-Pah-Hote, Martin Tristani-Firouzi, H Joseph Yost
Publikováno v:
PLoS Biology, Vol 17, Iss 9, p e3000087 (2019)
Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, t
Externí odkaz:
https://doaj.org/article/f8a5e13434264e2abe55149100bed06e
Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish
Publikováno v:
eLife, Vol 6 (2017)
Zebrafish Gdf3 (Dvr1) is a member of the TGFβ superfamily of cell signaling ligands that includes Xenopus Vg1 and mammalian Gdf1/3. Surprisingly, engineered homozygous mutants in zebrafish have no apparent phenotype. Elimination of Gdf3 in oocytes o
Externí odkaz:
https://doaj.org/article/bf9e13f67c85450584df8940c935529f
Autor:
Dustin Nash, Cammon B Arrington, Brett J Kennedy, Mark Yandell, Wilfred Wu, Wenying Zhang, Stephanie Ware, Lynn B Jorde, Peter J Gruber, H Joseph Yost, Neil E Bowles, Steven B Bleyl
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131514 (2015)
Most isolated congenital heart defects are thought to be sporadic and are often ascribed to multifactorial mechanisms with poorly understood genetics. Total Anomalous Pulmonary Venous Return (TAPVR) occurs in 1 in 15,000 live-born infants and occurs
Externí odkaz:
https://doaj.org/article/5d296e46b76342a9aa6f37b0d2e1d6c3
Autor:
Shiela C Samson, Tania Ferrer, Chuanchau J Jou, Frank B Sachse, Sunita S Shankaran, Robin M Shaw, Neil C Chi, Martin Tristani-Firouzi, H Joseph Yost
Publikováno v:
PLoS Biology, Vol 11, Iss 12, p e1001727 (2013)
The 3-O-sulfotransferase (3-OST) family catalyzes rare modifications of glycosaminoglycan chains on heparan sulfate proteoglycans, yet their biological functions are largely unknown. Knockdown of 3-OST-7 in zebrafish uncouples cardiac ventricular con
Externí odkaz:
https://doaj.org/article/13b0f2752e574d0fbe47499f334df7c3
Autor:
Colin T Maguire, Bradley L Demarest, Jonathon T Hill, James D Palmer, Arthur R Brothman, H Joseph Yost, Maureen L Condic
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53372 (2013)
Human amniotic fluid contains cells that potentially have important stem cell characteristics, yet the programs controlling their developmental potency are unclear. Here, we provide evidence that amniocytes derived from multiple patients are marked b
Externí odkaz:
https://doaj.org/article/69e633d15c1149fdbeb764e369c1dab9
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23457 (2011)
Plasmid DNA minipreps are fundamental techniques in molecular biology. Current plasmid DNA minipreps use alkali and the anionic detergent SDS in a three-solution format. In addition, alkali minipreps usually require additional column-based purificati
Externí odkaz:
https://doaj.org/article/0020a24ca37c4f0bba1ff980b07608bd
Autor:
Craig Sable, Jennifer S. Li, Martin Tristani‐Firouzi, Angela Fagerlin, Robert M. Silver, Mark Yandel, H. Joseph Yost, Andrea Beaton, James Dale, Mark Emmanuel Engel, David Watkins, Christopher Spurney, Asheley C. Skinner, Sarah C. Armstrong, Svati H. Shah, Norrina Allen, Matthew Davis, Lifang Hou, Linda Van Horn, Darwin Labarthe, Donald Lloyd‐Jones, Bradley Marino
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 7 (2023)
The American Heart Association's Strategically Focused Children's Research Network started in July 2017 with 4 unique programs at Children's National Hospital in Washington, DC; Duke University in Durham, North Carolina; University of Utah in Salt La
Externí odkaz:
https://doaj.org/article/a1c23aa891184b32b4c7b9d4ca6b6793
Autor:
Shahram Eisa-Beygi, Meng-Ming Hu, Suresh N. Kumar, Brooke E. Jeffery, Ross F. Collery, Nghia (Jack) Vo, Bhawika S. Lamichanne, H. Joseph Yost, Matthew B. Veldman, Brian A. Link
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology.
BACKGROUND: The goal of this study was to identify and characterize cell-cell interactions that facilitate endothelial tip cell fusion downstream of BMP (bone morphogenic protein)-mediated venous plexus formation. METHODS: High resolution and time-la
Autor:
Calum A. MacRae, Korak Chakraborti, H. Joseph Yost, Zachary P. Harmer, Manu Beerens, Jing-Ruey J. Yeh, Chelsea Herdman, Randall T. Peterson, Saba Parvez
Publikováno v:
Science
Screen time for CRISPR CRISPR-Cas9 has been used to edit the genomes of organisms ranging from fruit flies to primates, but it has not been used in large-scale genetic screens in animals because generating, validating, and keeping track of large numb
Autor:
Sergiusz Wesolowski, Alex Henrie, Martin Tristani-Firouzi, Vikrant Deshmukh, Michael D. Puchalski, Karen Eilbeck, Mark Yandell, Thomas A. Miller, Rashmee U. Shah, Rebecca K. Delaney, H. Joseph Yost, Derek Weyhrauch, Edgar Javier Hernandez, Bruce E. Bray, Gordon Lemmon
Publikováno v:
PLOS digital health. 1(1)
Understanding the conditionally-dependent clinical variables that drive cardiovascular health outcomes is a major challenge for precision medicine. Here, we deploy a recently developed massively scalable comorbidity discovery method called Poisson Bi