Zobrazeno 1 - 10
of 186
pro vyhledávání: '"H J Smits"'
Autor:
Fabienne Kocher, Violetta Applegate, Jens Reiners, Astrid Port, Dominik Spona, Sebastian Hänsch, Amin Mirzaiebadizi, Mohammad Reza Ahmadian, Sander H. J. Smits, Johannes H. Hegemann, Katja Mölleken
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract To enter epithelial cells, the obligate intracellular pathogen Chlamydia pneumoniae secretes early effector proteins, which bind to and modulate the host-cell’s plasma membrane and recruit several pivotal endocytic host proteins. Here, we
Externí odkaz:
https://doaj.org/article/2a73c453c2a44f94808310ce7e6a6a97
Autor:
Manuel T. Anlauf, Florestan L. Bilsing, Jens Reiners, Olivia Spitz, Eymen Hachani, Sander H. J. Smits, Lutz Schmitt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Type I secretion systems (T1SS) facilitate the secretion of substrates in one step across both membranes of Gram-negative bacteria. A prime example is the hemolysin T1SS which secretes the toxin HlyA. Secretion is energized by the ABC transp
Externí odkaz:
https://doaj.org/article/a0598cad15ab4e3883050d21aafba132
Autor:
Flaminia Mazzone, Moritz K. T. Klischan, Julian Greb, Sander H. J. Smits, Jörg Pietruszka, Klaus Pfeffer
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Toxoplasmosis is a zoonotic disease caused by Toxoplasma gondii, an apicomplexan parasite that infects approximately a third of the world’s human population. This disease can cause serious complications during pregnancy and can be fatal in immunoco
Externí odkaz:
https://doaj.org/article/6cc11104dc5b4666968309a56f7a9d1c
Autor:
Pablo Perez-Garcia, Jennifer Chow, Elisa Costanzi, Marno Gurschke, Jonas Dittrich, Robert F. Dierkes, Rebecka Molitor, Violetta Applegate, Golo Feuerriegel, Prince Tete, Dominik Danso, Stephan Thies, Julia Schumacher, Christopher Pfleger, Karl-Erich Jaeger, Holger Gohlke, Sander H. J. Smits, Ruth A. Schmitz, Wolfgang R. Streit
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Polyethylene terephthalate (PET) is a commodity polymer known to globally contaminate marine and terrestrial environments. Today, around 80 bacterial and fungal PET-active enzymes (PETases) are known, originating from four bacterial and two
Externí odkaz:
https://doaj.org/article/3f5a06e0963f4ed9ae54ed7aaef0b43a
Autor:
Isabelle N. Erenburg, Sebastian Hänsch, Feby M. Chacko, Anna Hamacher, Sebastian Wintgens, Fabian Stuhldreier, Gereon Poschmann, Olivia Spitz, Kai Stühler, Sebastian Wesselborg, Johannes H. Hegemann, Sander H. J. Smits, Stefanie Weidtkamp-Peters, Lutz Schmitt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native con
Externí odkaz:
https://doaj.org/article/37bf837447c345038a8921ad00a7000f
Autor:
Mohanraj Gopalswamy, Tobias Kroeger, David Bickel, Benedikt Frieg, Shahina Akter, Stephan Schott-Verdugo, Aldino Viegas, Thomas Pauly, Manuela Mayer, Julia Przibilla, Jens Reiners, Luitgard Nagel-Steger, Sander H. J. Smits, Georg Groth, Manuel Etzkorn, Holger Gohlke
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Acute myeloid leukemia (AML) is a malignant disease of immature myeloid cells and the most prevalent acute leukemia among adults. The oncogenic homo-tetrameric fusion protein RUNX1/ETO results from the chromosomal translocation t(8;21) and i
Externí odkaz:
https://doaj.org/article/aeaec08cbc53466ab4dd597d8162db4f
Autor:
Julia Gottstein, Julia Zaschke-Kriesche, Sandra Unsleber, Irina Voitsekhovskaia, Andreas Kulik, Lara V. Behrmann, Nina Overbeck, Kai Stühler, Evi Stegmann, Sander H. J. Smits
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Treatment of bacterial infections is one of the major challenges of our time due to the evolved resistance mechanisms of pathogens against antibiotics. To circumvent this problem, it is necessary to understand the mode of action of the drug
Externí odkaz:
https://doaj.org/article/498c4eaaaf0242af97e1f185298e7d9b
Autor:
C. Vivien Knospe, Michael Kamel, Olivia Spitz, Astrid Hoeppner, Stefanie Galle, Jens Reiners, Alexej Kedrov, Sander H. J. Smits, Lutz Schmitt
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
The rapid emergence of microbial multi-resistance against antibiotics has led to intense search for alternatives. One of these alternatives are ribosomally synthesized and post-translationally modified peptides (RiPPs), especially lantibiotics. They
Externí odkaz:
https://doaj.org/article/305800b6f87e4c338dd295b22eaecb64
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The ABC transporter hemolysin B (HlyB) is the key protein of the HlyA secretion system, a paradigm of type 1 secretion systems (T1SS). T1SS catalyze the one-step substrate transport across both membranes of Gram-negative bacteria. The HlyA T1SS is co
Externí odkaz:
https://doaj.org/article/f6a089f934d645288f2198cd5e385bcb
Autor:
Athanasios Papadopoulos, Max Busch, Jens Reiners, Eymen Hachani, Miriam Baeumers, Julia Berger, Lutz Schmitt, Karl-Erich Jaeger, Filip Kovacic, Sander H. J. Smits, Alexej Kedrov
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Pseudomonas aeruginosa is a wide-spread opportunistic human pathogen and a high-risk factor for immunodeficient people and patients with cystic fibrosis. The extracellular lipase A belongs to the virulence factors of P. aeruginosa. Prior to the secre
Externí odkaz:
https://doaj.org/article/8c75dcca33a443e49cbb010527fa90cd