Výsledky vyhledávání

Pathogenesis of malignant ascites: Starling’s law of capillary hemodynamics revisited

Autor: Jouke T. Tamsma, Arend E Meinders, H. J. Keizer

Publikováno v: Annals of Oncology. 12:1353-1357

Peritonitis carcinomatosa, indicating the presence of malignant cells in the peritoneal cavity, is a well-known complication of malignant disease. As a result, so-called malignant ascites develops. Malignant ascites is a debilitating condition for wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2c5e0881d4f4c041810ff1ba386243
https://doi.org/10.1023/a:1012504904713

Zobrazit plný text záznamu

Population pharmacokinetics and exploratory pharmacodynamics of ifosfamide and metabolites after a 72-h continuous infusion in patients with soft tissue sarcoma

Autor: Sjoerd Rodenhuis, Ron A. A. Mathot, H. J. Keizer, Jos H. Beijnen, Jan Ouwerkerk, Jan H.M. Schellens, T. Kerbusch

Publikováno v: European Journal of Clinical Pharmacology. 57:467-477

Objective: The population pharmacokinetics and pharmacodynamics of the cytostatic agent ifosfamide and its main metabolites 2- and 3-dechloroethylifosfamide and 4-hydroxyifosfamide were assessed in patients with soft tissue sarcoma. Methods: Twenty p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f898a951a2cb1716a0d0211353b7f1b4
https://doi.org/10.1007/s002280100322

Zobrazit plný text záznamu

Evaluation of the autoinduction of ifosfamide metabolism by a population pharmacokinetic approach using NONMEM

Autor: H. J. Keizer, Thomas Kerbusch, J. Ouwerkerk, A. D. R. Huitema, Jan H.M. Schellens, Ron A. A. Mathot, Jos H. Beijnen

Publikováno v: British Journal of Clinical Pharmacology. 49:555-561

Aims This study investigated the population pharmacokinetics of ifosfamide in 15 patients treated for soft tissue sarcoma with 9 or 12 g m−2 ifosfamide by means of a 72 h continuous i.v. infusion. Methods A model was developed using nonlinear mixed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17142a962c7891241b890e4a7aaae9cc
https://doi.org/10.1046/j.1365-2125.2000.00217.x

Zobrazit plný text záznamu

Prediction models for the histology of residual masses after chemotherapy for metastatic testicular cancer

Autor: Ewout W. Steyerberg, H. J. Keizer, J. D. F. Habbema

Publikováno v: International Journal of Cancer. 83:856-859

Patients with metastatic non-seminomatous testicular cancer can be cured by cisplatin-based chemotherapy. After chemotherapy, surgical resection is a generally accepted treatment to remove remnants of the initial metastases since residual tumor may s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48f6f5f190620f6c27f487bc5292676f
https://doi.org/10.1002/(sici)1097-0215(19991210)83:6<856::aid-ijc31>3.0.co

Zobrazit plný text záznamu

Use of granisetron in patients refractory to previous treatment with antiemetics

Autor: H J Keizer, J Milliez, A E Schindler, J Carmichael, D Cupissol, P Scheidel

Publikováno v: Anti-Cancer Drugs. 9:381-385

A multicenter, open-label, compassionate-use trial studied the antiemetic efficacy and tolerability of granisetron in patients who had failed other antiemetic therapies in previous cycles of cytostatic chemotherapy. The antiemetics that had been used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99bc413a026a9fe3c67db9af4eb96ca1
https://doi.org/10.1097/00001813-199806000-00002

Zobrazit plný text záznamu

Isolated Liver Perfusion with Mitomycin C in the Treatment of Colorectal Cancer Metastases Confined to the Liver

Autor: H. J. Keizer, A. Marinelli, U. R. Tjaden, J.H. van Bockel, L. M. de Brauw, C.J.H. van de Velde, H. Beerman

Publikováno v: Japanese Journal of Clinical Oncology. 26:341-350

We evaluated the technical feasibility of isolated liver perfusion (ILP) in the treatment of patients with colorectal cancer metastases confined to the liver, and investigated whether ILP allows exposure of the tumor to high concentrations of mitomyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327dfec865210a76297cae9075f59f63
https://doi.org/10.1093/oxfordjournals.jjco.a023243

Zobrazit plný text záznamu

Prediction of residual retroperitoneal mass histology after chemotherapy for metastatic nonseminomatous germ cell tumor: multivariate analysis of individual patient data from six study groups

Autor: Jonathan E. Messemer, H. J. Keizer, Guy C. Toner, John P. Donohue, H. Schraffordt Koops, Sophie D. Fosså, Ewout W. Steyerberg, Dt Sleijfer, P.F.A. Mulders, K. Ney

Publikováno v: Journal of Clinical Oncology. 13:1177-1187

PURPOSE To develop a statistical model that predicts the histology (necrosis, mature teratoma, or cancer) after chemotherapy for metastatic nonseminomatous germ cell tumor (NSGCT). PATIENTS AND METHODS An international data set was collected comprisi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1f6923d79233c0aa92b9ae6e25b83e
https://doi.org/10.1200/jco.1995.13.5.1177

Zobrazit plný text záznamu

Inhibition of fluorouracil catabolism in cancer patients by the antiviral agent (E)-5-(2-bromovinyl)-2′-deoxyuridine

Autor: H. J. Keizer, E. De Clercq, U.R. Tjaden, E. A. De Bruijn

Publikováno v: Journal of cancer research and clinical oncology

The thymidine analogue (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdUrd), which is an antiviral agent effective against herpes simplex virus type 1 and varicella zoster virus, has also proved to be a potent inhibitor of dihydrouracil dehydrogenase, the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537bb5bac7d4c02bc8627d2d212b613e
https://doi.org/10.1007/bf01221032

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání