Zobrazeno 1 - 10
of 85
pro vyhledávání: '"H J Hoeijmakers"'
Autor:
Steffen Erkelenz, Marta Grzonka, Antonios Papadakis, Heiner Schaal, Jan H. J. Hoeijmakers, Ákos Gyenis
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-13 (2024)
Rbm3 (RNA-binding motif protein 3) is a stress responsive gene, which maintains cellular homeostasis and promotes survival upon various harmful cellular stimuli. Rbm3 protein shows conserved structural and molecular similarities to heterogeneous nucl
Externí odkaz:
https://doaj.org/article/b7fdbcb105a146a39dbe9107f8d6a92e
Autor:
Diana A. Llerena Schiffmacher, Shun-Hsiao Lee, Katarzyna W. Kliza, Arjan F. Theil, Masaki Akita, Angela Helfricht, Karel Bezstarosti, Camila Gonzalo-Hansen, Haico van Attikum, Matty Verlaan-de Vries, Alfred C. O. Vertegaal, Jan H. J. Hoeijmakers, Jurgen A. Marteijn, Hannes Lans, Jeroen A. A. Demmers, Michiel Vermeulen, Titia K. Sixma, Tomoo Ogi, Wim Vermeulen, Alex Pines
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to c
Externí odkaz:
https://doaj.org/article/ae22f3558ad948a0bf15ffe295f5314c
Autor:
Yupeng He, Wei Yang, Luojiao Huang, Marlien Admiraal‐van Mever, Rawi Ramautar, Amy Harms, Yvonne Rijksen, Renata M.C. Brandt, Sander Barnhoorn, Kimberly Smit, Dick Jaarsma, Peter Lindenburg, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Thomas Hankemeier
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 868-882 (2024)
Abstract Background Sarcopenia is characterized by loss of skeletal muscle mass and function, and is a major risk factor for disability and independence in the elderly. Effective medication is not available. Dietary restriction (DR) has been found to
Externí odkaz:
https://doaj.org/article/1ec04aabc7c74f87acd7dc184a5a718a
Autor:
Sander Barnhoorn, Marcel E Meima, Robin P Peeters, Veerle M Darras, Selmar Leeuwenburgh, Jan H J Hoeijmakers, Wilbert P Vermeij, W Edward Visser
Publikováno v:
European Thyroid Journal, Vol 12, Iss 6, Pp 1-10 (2023)
Background: Thyroid hormone signaling is essential for development, metabolism, and response to stress but declines during aging, the cause of which is unknown. DNA damage accumulating with time is a main cause of aging, driving many age-related dise
Externí odkaz:
https://doaj.org/article/f7af7f3f184c4cbe9795ae267498776b
Autor:
C. A. J. Oudmaijer, R. C. Minnee, R. A. Pol, W. M. C. van den Boogaard, D. S. J. Komninos, J. van de Wetering, M. H. van Heugten, E. J. Hoorn, J. S. F. Sanders, J. H. J. Hoeijmakers, W. P. Vermeij, J. N. M. IJzermans
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-10 (2022)
Abstract Background One of the main effectors on the quality of life of living-kidney donors is postoperative fatigue. Caloric restriction (CR) and short-term fasting (STF) are associated with improved fitness and increased resistance to acute stress
Externí odkaz:
https://doaj.org/article/1e6c93f2a303480c980a078fa097cbce
Autor:
María Björk Birkisdóttir, Lisanne J. Van’t Sant, Renata M. C. Brandt, Sander Barnhoorn, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2023)
Dietary restriction (DR) is a universal anti-aging intervention, which reduces age-related nervous system pathologies and neurological decline. The degree to which the neuroprotective effect of DR operates by attenuating cell intrinsic degradative pr
Externí odkaz:
https://doaj.org/article/7c717516e8b847deb8a36a926fa4cca9
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Externí odkaz:
https://doaj.org/article/44a09dce31cb497bae23d58181211464
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging. Interventions that either prevent DNA damage or enhance DNA repair are thus likely to extend health- a
Externí odkaz:
https://doaj.org/article/8c65fef761fc4154867530db3ca88371
Autor:
Lisanne J. van’t Sant, Joshua J. White, Jan H. J. Hoeijmakers, Wilbert P. Vermeij, Dick Jaarsma
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-20 (2021)
Abstract Fluorescent staining of newly transcribed RNA via metabolic labelling with 5-ethynyluridine (EU) and click chemistry enables visualisation of changes in transcription, such as in conditions of cellular stress. Here, we tested whether EU labe
Externí odkaz:
https://doaj.org/article/ef45f63d26b14d52901530cdf2a81f48
Autor:
Gustavo S. Kajitani, Carolina Quayle, Camila C. M. Garcia, Wesley L. Fotoran, Juliana F. R. dos Santos, Gijsbertus T. J. van der Horst, Jan H. J. Hoeijmakers, Carlos F. M. Menck
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Ultraviolet (UV) radiation is one of the most genotoxic, universal agents present in the environment. UVB (280-315 nm) radiation directly damages DNA, producing cyclobutane pyrimidine dimers (CPDs) and pyrimidine 6-4 pyrimidone photoproducts (6-4PPs)
Externí odkaz:
https://doaj.org/article/1f02638873fb413699c79902773da7fe