Výsledky vyhledávání - "H J, Schlicht"

Accumulation of 8-Hydroxy-2’- Deoxyguanosine Adducts in HBx Recombinant HepG2 Cells and HBx Transgenic Mice

Autor: Wolfgang H. Caselmann, Peter Hans Hofschneider, Christian Rabe, Kurt Reifenberg, Maria Brauchle, Ralph Gehrke, Eberhard Hildt, Uwe Gruetzner, H J Schlicht, Volker Schmitz

Publikováno v: Digestion. 70:117-126

Background/Aims: Transgenic mice overexpressing hepatitis B x protein (HBx) show an increased susceptibility to mutations if exposed to mutagens. Also involved in HBx signalling, reactive oxygen intermediates (ROI) can induce DNA adducts such as 8-hy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25fe50804cfda9f9ff04cb0f68a4f98
https://doi.org/10.1159/000080930

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The Hepatitis B Virus e Antigen Cannot Pass the Murine Placenta Efficiently and Does Not Induce CTL Immune Tolerance in H-2bMicein Utero

Autor: Jens Wild, Reinhold Schirmbeck, Iris Gastrock-Balitsch, Ralph Hanano, Kurt Reifenberg, Tom Deutschle, H J Schlicht

Publikováno v: Virology. 243(1):45-53

The function of the secretory core gene product (HBeAg) of the human hepatitis B virus is unclear. It has been discussed that this protein may be passed from the mother to the fetus, where it might induce immunologic tolerance. Here we have examined

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7539de7fa57552d782415df07ce3bf

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Long-term expression of the hepatitis B virus core-e- and X-proteins does not cause pathologic changes in transgenic mice

Autor: Hans-Peter Pudollek, Eva Maria Schmitteckert, Kurt Reifenberg, H J Schlicht, Gabriele Spindler, Jürgen Löhler, Josef Köck

Publikováno v: Journal of Hepatology. 26:119-130

Background/Aims: Chronic infections with the human hepatitis B virus can result in liver cirrhosis and primary hepatocellular carcinoma. The reasons for these long-term effects are unclear. The aim of this study was to generate transgenic mice expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a491c182ffa6d01c6e083a47e0e697
https://doi.org/10.1016/s0168-8278(97)80018-9

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Uptake of duck hepatitis B virus into hepatocytes occurs by endocytosis but does not require passage of the virus through an acidic intracellular compartment

Autor: H J Schlicht, J Köck, E M Borst

Publikováno v: Journal of Virology. 70:5827-5831

The infectious entry pathway of duck hepatitis B virus (DHBV) was investigated with primary duck hepatocytes. Virus uptake was measured by a selective PCR technique which allows for the detection of a successful infection without the need for viral r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56657d5c0df8caed182e42baf3c15db3
https://doi.org/10.1128/jvi.70.9.5827-5831.1996

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Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus

Autor: L Theilmann, P Galle, H J Schlicht, J Köck

Publikováno v: Hepatology. 23:405-413

There have been numerous reports suggesting that human peripheral blood mononuclear cells (PBMCs) can be productively infected with human hepatitis B virus (HBV). We therefore examined whether the PBMCs can be used to establish an in vitro infection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::483a35e2493af905305d6012749939c5
https://doi.org/10.1002/hep.510230303

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Further Characterization of 2 Types of Precore Variant Hepatitis B Virus Isolates from Hong Kong

Autor: William F. Carman, H J Schlicht, Edward C. Holmes, Karin Hanrieder, Winifred Boner

Publikováno v: Journal of Infectious Diseases. 171:1461-1467

0.Two precore variants of hepatitis B virus occur in chronic carriers in the Chinese community in Hong Kong. One variant has a serine at amino acid (aa) 15, and the other has a stop codon at aa 28, which inhibits production of hepatitis B e (HBe) ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b750a141d776e81082ac59bc93103c95
https://doi.org/10.1093/infdis/171.6.1461

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Human cytomegalovirus UL97 kinase confers ganciclovir susceptibility to recombinant vaccinia virus

Autor: Karin Schneider, C Metzger, Anke Lüske, Detlef Michel, Thomas Mertens, H J Schlicht

Publikováno v: Journal of Virology. 68:8423-8427

We analyzed whether the phosphotransferase encoded by the UL97 open reading frame of human cytomegalovirus (HCMV) alone is sufficient to confer ganciclovir (GCV) susceptibility to a foreign virus. Two vaccinia virus recombinants (T1 and A5) containin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2653e627be7ee0e1987d4b4f82c4a7d4
https://doi.org/10.1128/jvi.68.12.8423-8427.1994

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Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity

Autor: H J Schlicht, J Köck

Publikováno v: Journal of Virology. 67:4867-4874

Hepadnaviruses contain a relaxed circular DNA genome (RC-DNA) with discontinuities in both strands. Upon infectious entry into a host cell, this genome is converted into a covalently closed superhelical form (CCC-DNA), which later serves as the templ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ebd018889072d724af4af10ba99634
https://doi.org/10.1128/jvi.67.8.4867-4874.1993

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Definition of a minimal optimal cytotoxic T-cell epitope within the hepatitis B virus nucleocapsid protein

Autor: L. Galati, Francis V. Chisari, A Vitiello, H J Schlicht, S Guilhot, P Fowler, Amalia Penna, R C Chesnut, Gabriele Missale, Antonio Bertoletti

Publikováno v: Journal of Virology. 67:2376-2380

Residues 11 to 27 of the hepatitis B virus nucleocapsid antigen contain a cytotoxic T-cell epitope that is recognized by cytotoxic T cells from virtually all HLA-A2-positive patients with acute hepatitis B virus infection. Using panels of truncated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb053d5b8e58817631549eae39435e5
https://doi.org/10.1128/jvi.67.4.2376-2380.1993

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