Zobrazeno 1 - 10
of 14
pro vyhledávání: '"H J, Pieniaszek"'
Publikováno v:
Alimentary pharmacologytherapeutics. 30(3)
Summary Background Oral tablet formulations of metoclopramide are effective therapies for gastroparesis and gastro-oesophageal reflux disease; however, difficulty swallowing tablets or nausea/vomiting may reduce patient adherence to therapy. Because
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f1e8765ebe0b158a9a2d5949e5530f
https://pubmed.ncbi.nlm.nih.gov/19459829
https://pubmed.ncbi.nlm.nih.gov/19459829
Autor:
A S, Joshi, H J, Pieniaszek, E E, Vokes, N J, Vogelzang, A F, Davidson, L E, Richards, M F, Chai, M, Finizio, M J, Ratain
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(2)
Losoxantrone is an anthrapyrazole derivative in Phase III development in the U.S. for solid tumors, notably breast cancer. To obtain information on the routes of elimination of the drug, a study was conducted in four patients with advanced solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65b3e4df6fcbcf98e17bcbe4c9047eec
https://pubmed.ncbi.nlm.nih.gov/11159796
https://pubmed.ncbi.nlm.nih.gov/11159796
Autor:
J S, Barrett, J, Yu, R, Kapil, P, Padovani, F, Brown, W F, Ebling, M H, Corjay, T M, Reilly, J M, Bozarth, S A, Mousa, H J, Pieniaszek
Publikováno v:
Biopharmaceuticsdrug disposition. 20(6)
The disposition of XV459, a potent, selective GP IIb/IIIa antagonist, has been examined following intravenous administration of XP280, the benzenesulphonate salt, and 3H-SA202, the trifluroacetic acid salt, to male guinea pigs. A liquid chromatograph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3dfb7efe39f7c05835ccca95de12832
https://pubmed.ncbi.nlm.nih.gov/10701702
https://pubmed.ncbi.nlm.nih.gov/10701702
Autor:
H. J. Pieniaszek, J. M. Read, P. N. Confalone, G. O. Page, A. F. Davidson, L. E. Richards, S. Shatzmiller, K. F. Blom
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 27(2)
1. Using synthetic standards and/or spectral data, seven moricizine metabolites were structurally identified in human urine. Two novel metabolites were identified as phenothiazine-2-carbamic acid and ethyl [10-(3-aminopropionyl) phenothiazin-2-yl] ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd73c54b17a148dd0b42b7f1d15a2152
https://pubmed.ncbi.nlm.nih.gov/9058534
https://pubmed.ncbi.nlm.nih.gov/9058534
Publikováno v:
Pharmaceutical research. 12(12)
To examine the pharmacokinetics of warfarin after administration of single oral doses (2, 5, and 10 mg) to healthy male volunteers.A sensitive reverse-phase HPLC method was used to quantify warfarin plasma concentrations as low as 6 ng/ml. Blood samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec739c15ab9f137a3a7149ef643658ac
https://pubmed.ncbi.nlm.nih.gov/8786959
https://pubmed.ncbi.nlm.nih.gov/8786959
Publikováno v:
Research communications in chemical pathology and pharmacology. 81(2)
A single dose pharmacokinetic study with modified human Interleukin-1 Beta (IL-1 beta or DuP 118) was performed by injecting 5 micrograms/kg of drug into the jugular vein of three beagle dogs. Serial 5-ml plasma samples were removed from the dogs ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9c64de4151b8341c9f81fe1d1b474171
https://pubmed.ncbi.nlm.nih.gov/8210701
https://pubmed.ncbi.nlm.nih.gov/8210701
Publikováno v:
Research communications in chemical pathology and pharmacology. 75(3)
We studied the influence of chronic moricizine hydrochloride (MRZ) treatment on the drug's pharmacokinetics and on drug metabolizing enzyme activities in rats. Separate groups of 8 rats (4 males and 4 females) were treated with 40 and 100 mg/kg oral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4e34399782c78746f6b517274b2171e
https://pubmed.ncbi.nlm.nih.gov/1509197
https://pubmed.ncbi.nlm.nih.gov/1509197
Autor:
R. N. Fogoros, Charles C. Whitney, Denise L. Howrie, W. L. Schary, H. J. Pieniaszek, Randy P. Juhl, Lewis W. Dittert
Publikováno v:
European Journal of Clinical Pharmacology. 32:607-610
Moracizine (ethmozine) is a phenothiazine derivative with demonstrated antiarrhythmic activity. To characterize the pharmacokinetics and material balance relationships in humans, we have given 14C-moracizine X HCl as a single oral dose of 500 mg (50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff377e9085f8b29370d43d7d6f38aa1d
https://doi.org/10.1007/bf02455996
https://doi.org/10.1007/bf02455996
Autor:
Barrett, J. S., Hainer, J. W., Kornhauser, D. M., Gaskill, J. L., Hua, T. A., Sprogel, P., Johansen, K., Lier, J. J. van, Knebel, W., Jr., H. J. Pieniaszek
Publikováno v:
Thrombosis Research; 2001, Vol. 101 Issue: 4 p243-254, 12p
Autor:
H J, Pieniaszek, T R, Bates
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 198(1)
The effect of multiple oral administration of the hypocholesterolemic agent cholestyramine (a strongly basic anion-exchange resin) on the metabolism of salicylazosulfapyridine by microflora present in the colon and cecum was assessed in conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e98d23afe19a774d1b2dcbefd5103eb
https://pubmed.ncbi.nlm.nih.gov/6792
https://pubmed.ncbi.nlm.nih.gov/6792