Zobrazeno 1 - 10
of 22
pro vyhledávání: '"H J, Hausleiter"'
Autor:
R. Saller, P. Brockmann, A. Hellstern, D. Hellenbrecht, H J Hausleiter, M. Gatzen, G. Achtert
Publikováno v:
European Journal of Clinical Pharmacology. 45:415-418
The biliary excretion and apparent oral clearance of metoclopramide (MCL) were determined after oral administration of 1 mg MCL/kg body weight to 10 patients suffering from extrahepatic cholestasis with nasobiliary tube for drainage of the common bil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a79fc7e546de4902f2a9efd904c08f
https://doi.org/10.1007/bf00315511
https://doi.org/10.1007/bf00315511
Publikováno v:
Oncology. 50:81-85
The antiemetic effect of oral medium-dosed metoclopramide (MCL, 3.5 mg/kg b.w./cycle) and placebo for chemotherapy-induced emesis of a noncisplatin regimen was assessed for inpatients and outpatients in two double-blind placebo-controlled sequential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232b183bad47445f3705209a9d17cc29
https://doi.org/10.1159/000227153
https://doi.org/10.1159/000227153
Publikováno v:
Arzneimittel-Forschung. 41(12)
Pharmacokinetics and relative bioavailability of the marketed prajmalium bitartrate tablet (Neo-Gilurytmal, CAS 2589-47-1) compared to an oral solution were investigated in an open, randomized, single-dose two-fold crossover study in 20 healthy male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ad221bb8804769acd55630dbeec6c90
https://pubmed.ncbi.nlm.nih.gov/1815520
https://pubmed.ncbi.nlm.nih.gov/1815520
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 14:249-256
After oral administration to rats, absorption of INAA was slow but complete. Plasma level curves reached a plateau for INAA as well as for the two metabolites, which were rapidly formed (MI and Mil). The plateau concentration led to an increase of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d50c74edf4f3e897b174c3c7737178
https://doi.org/10.1007/bf03190107
https://doi.org/10.1007/bf03190107
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 7:329-339
Nach Applikation von N-Propyl-ajmalin-hydrogentartrat (N-PAB, Neo-Gilurytmal®) in den Dosierungen 10 mg i.v. und 20 mg p.o. wurden Pharmakokinetik und Metabolismus an sechs gesunden mannlichen Freiwilligen untersucht. Fur die Untersuchung wurde14C-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17f5c9a6ba7359f089e1dba82835caf1
https://doi.org/10.1007/bf03189637
https://doi.org/10.1007/bf03189637
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 12:77-82
11 patients (9m, 2f, median age 59 years) with ventricular ectopic activity of at least Lown grade III received 20 mg N-Propyl-ajmaline-bitartrate (N-PAB) p.o. Plasma concentrations of N-PAB were determined with HPLC from blood samples within 26 hour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad3310dc132ad242c12fc9d859dee0e3
https://doi.org/10.1007/bf03189865
https://doi.org/10.1007/bf03189865
Autor:
A. Hellstern, D. Hellenbrecht, L Briemann, M Hodgson, R. Saller, H J Hausleiter, G. Achtert, H. Hess, P. Mitrou, P. Brockmann
Publikováno v:
Clinical Pharmacology and Therapeutics. 37:43-47
Eleven male subjects aged 24 to 58 yr received cisplatin, 90 to 120 mg/m2 iv, in combination with other cytostatic drugs such as doxorubicin HC1 and bleomycin. To prevent emesis, two high-dose metoclopramide regimens were started 2 hr before cytostat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde8e9672109b02900406d6f04ca45b1
https://doi.org/10.1038/clpt.1985.9
https://doi.org/10.1038/clpt.1985.9
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 9:325-346
The metabolism of 7-bromo-1-methyl-2-methoxymethyl-5-(2'-chlorophenyl)-2, 3-dihydro-1H-1,4-benzodiazepine (metaclazepam, Talis) in animals and men is described. Based upon mass spectrometry fifteen metabolites could be identified. Qualitative and qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae661ce5b697aa78e68887b75c72c97b
https://doi.org/10.1007/bf03189684
https://doi.org/10.1007/bf03189684
Publikováno v:
Klinische Wochenschrift. 63:1180-1186
In order to determine whether the metabolism of the antiarrhythmic drug N-propylajmaline is under the same genetic control as sparteine metabolism, the pharmacokinetics of this antiarrhythmic drug were studied in a groups of six extensive and four po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6240cf2bfcfc2cdbe293530b7aa31e
https://doi.org/10.1007/bf01740595
https://doi.org/10.1007/bf01740595
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 419:351-356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d6accb45969e46a00e9aecb8919bd1
https://doi.org/10.1016/0378-4347(87)80299-2
https://doi.org/10.1016/0378-4347(87)80299-2