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Elektronická kniha

Autor: H. J. Fromm

Enzyme kinetics has undergone very rapid growth and development during the past fifteen years and has been well received by the biochemical community. A cursory glance at the current biochem ical literature reveals the increasing popularity of enzy

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Akademický článek

Cordycepin Modulates Microglial M2 Polarization Coupled with Mitochondrial Metabolic Reprogramming by Targeting HKII and PDK2.

Autor: Zhong, Xin¹, Gong, Shiqiang^1,2, Meng, Linghui³, Yao, Weifan^1,2, Du, Ke¹, Jiao, Linchi¹, Ma, Guowei¹, Liang, Jingwei¹, Wei, Binbin¹, Jin, Xin¹, Tong, Junhui¹, Dong, Jianru¹, Liu, Mengyu¹, Gao, Menglin¹, Jia, Huachao¹, Jiang, Wenjuan⁴, Yu, Zhihua⁵, Wang, Yanzhe⁴, Sun, Xiaohong⁶ xhsun@cmu.edu.cn, Wei, Minjie^1,2 mjwei@cmu.edu.cn

Publikováno v: Advanced Science. 8/21/2024, Vol. 11 Issue 31, p1-18. 18p.

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Environment of tryptophan 57 in porcine fructose-1,6-bisphosphatase studied by time-resolved fluorescence and site-directed mutagenesis

Autor: J, Wen, S W, Nelson, R B, Honzatko, H J, Fromm, J W, Petrich

Publikováno v: Photochemistry and photobiology. 74(5)

The environment of Trp57, introduced by the mutation of a tyrosine in the dynamic loop of porcine liver fructose-1,6-bisphosphatase (FBPase), was examined using time-resolved fluorescence and directed mutation. The Trp57 enzyme was studied previously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::359f413365fd5b9160b8eadf98a914e8
https://pubmed.ncbi.nlm.nih.gov/11723795

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Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes relevant to allosteric regulation

Autor: A E, Aleshin, C, Kirby, X, Liu, G P, Bourenkov, H D, Bartunik, H J, Fromm, R B, Honzatko

Publikováno v: Journal of molecular biology. 296(4)

Hexokinase I, the pacemaker of glycolysis in brain tissue, is composed of two structurally similar halves connected by an alpha-helix. The enzyme dimerizes at elevated protein concentrations in solution and in crystal structures; however, almost all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fd37f9c8bd9d511af83c2dda8c5df70
https://pubmed.ncbi.nlm.nih.gov/10686099

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Adenylosuccinate synthetase: recent developments

Autor: R B, Honzatko, M M, Stayton, H J, Fromm

Publikováno v: Advances in enzymology and related areas of molecular biology. 73

By exerting strategic control on purine nucleotide biosynthesis, and by engaging GTP-dependent transphosphorylation of IMP to activate loss of an oxygen atom during catalysis, adenylosuccinate synthetase remains as enzyme that justifiably fascinates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::42d65cc2daf4d5795980490edb9cdc40
https://pubmed.ncbi.nlm.nih.gov/10218106

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Regulation of hexokinase I: crystal structure of recombinant human brain hexokinase complexed with glucose and phosphate

Autor: A E, Aleshin, C, Zeng, H D, Bartunik, H J, Fromm, R B, Honzatko

Publikováno v: Journal of molecular biology. 282(2)

Hexokinase I, the pacemaker of glycolysis in brain tissue and red blood cells, is comprised of two similar domains fused into a single polypeptide chain. The C-terminal half of hexokinase I is catalytically active, whereas the N-terminal half is nece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f76174a62446946f2ff02511d36f42f
https://pubmed.ncbi.nlm.nih.gov/9735292

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