Zobrazeno 1 - 10
of 140
pro vyhledávání: '"H I Yamamura"'
Autor:
K A, Witt, J D, Huber, R D, Egleton, M J, Roberts, M D, Bentley, L, Guo, H, Wei, H I, Yamamura, T P, Davis
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 298(2)
Poly(ethylene glycol), or PEG, conjugation to proteins and peptides is a growing technology used to enhance efficacy of therapeutics. This investigation assesses pharmacodynamic and pharmacokinetic characteristics of PEG-conjugated [D-Pen2,D-Pen5]-en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9d159d7ffaa430ac874a6a8b31d06b0
https://pubmed.ncbi.nlm.nih.gov/11454951
https://pubmed.ncbi.nlm.nih.gov/11454951
Autor:
S, Liao, M, Shenderovich, K E, Kövér, Z, Zhang, K, Hosohata, P, Davis, F, Porreca, H I, Yamamura, V J, Hurby
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 57(4)
Replacement of Phe3 in the endogenous delta-opioid selective peptide deltorphin I with four optically pure stereoisomers of the topographically constrained, highly hydrophobic novel amino acid beta-isopropylphenylalanine (beta-iPrPhe) produced four p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbb3879b61397fd067265c81455e4346
https://pubmed.ncbi.nlm.nih.gov/11328484
https://pubmed.ncbi.nlm.nih.gov/11328484
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(1)
Reverse transcription-polymerase chain reaction was used to identify the pertussis toxin (Ptx)-sensitive G protein alpha-subunit pool in Chinese hamster ovary (CHO) and mouse fibroblast (B82) cells. We detected the presence of mRNA for G(ialpha2), G(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d41f9c3ee53e46495b697f36638bdb5
https://pubmed.ncbi.nlm.nih.gov/10604950
https://pubmed.ncbi.nlm.nih.gov/10604950
Autor:
R M, Quock, T H, Burkey, E, Varga, Y, Hosohata, K, Hosohata, S M, Cowell, C A, Slate, F J, Ehlert, W R, Roeske, H I, Yamamura
Publikováno v:
Pharmacological reviews. 51(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7658ef75a8f46af37d06b8df34ce76b2
https://pubmed.ncbi.nlm.nih.gov/10471416
https://pubmed.ncbi.nlm.nih.gov/10471416
Autor:
H, Bartosz-Bechowski, P, Davis, J, Slaninova, E, Malatynska, D, Stropova, F, Porreca, H I, Yamamura, V J, Hruby
Publikováno v:
The journal of peptide research : official journal of the American Peptide Society. 53(3)
We report here on the binding affinity and bioassay results of cyclic enkephalin analogs comprising a cyclic moiety and C-terminal fragment of MERGL, where ME denotes methionine enkephalin. MERGL (YGGFMRGL) has been suggested to be cleaved enzymatica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::699e2f14fb5c50be1bfddbb012878ad1
https://pubmed.ncbi.nlm.nih.gov/10231722
https://pubmed.ncbi.nlm.nih.gov/10231722
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 284(2)
The coding sequence of the human m2 receptor gene was amplified by polymerase chain reaction and stably transfected into a murine fibroblast cell line (B82). We have compared the human M2 clonal cell line (HM2-B10) with the previously established B82
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1c22a004fc30c78082ff1eed0c4494e
https://pubmed.ncbi.nlm.nih.gov/9454790
https://pubmed.ncbi.nlm.nih.gov/9454790
Autor:
E V, Varga, X, Li, D, Stropova, T, Zalewska, R S, Landsman, R J, Knapp, E, Malatynska, K, Kawai, A, Mizusura, H, Nagase, S N, Calderon, K, Rice, V J, Hruby, W R, Roeske, H I, Yamamura
Publikováno v:
Molecular pharmacology. 50(6)
In the present study, we replaced the third extracellular loop of the human delta-opioid receptor with that of the human mu-opioid receptor. A modified polymerase chain reaction overlap extension method was used to achieve the exact splicing in the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a2a23aa3dcf79250e583887ac158822a
https://pubmed.ncbi.nlm.nih.gov/8967985
https://pubmed.ncbi.nlm.nih.gov/8967985
Autor:
E, Malatynska, Y, Wang, R J, Knapp, S, Waite, S, Calderon, K, Rice, V J, Hruby, H I, Yamamura, W R, Roeske
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(3)
The SNC-80 series of nonpeptidic agonists for the delta-opioid receptor are being developed as potential analgesic drugs. It is important to understand their acute and chronic effects at human delta-opioid receptors. Thus, we measured the ability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::70a4c531bbeacfa6d4d1469151a57c2e
https://pubmed.ncbi.nlm.nih.gov/8819489
https://pubmed.ncbi.nlm.nih.gov/8819489
Autor:
R J, Knapp, G, Santoro, I A, De Leon, K B, Lee, S A, Edsall, S, Waite, E, Malatynska, E, Varga, S N, Calderon, K C, Rice, R B, Rothman, F, Porreca, W R, Roeske, H I, Yamamura
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
The racemic compound (+/-)-BW373U86 ¿(+/-)-4-((alpha R*)- alpha-((2S*,5R*)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxy- benzyl)-N,N-diethylbenzamide dihydrochloride} is a potent delta opioid receptor agonist in the mouse vas deferens assay with li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0df12c232e3c9a3243f2d836a034905b
https://pubmed.ncbi.nlm.nih.gov/8667189
https://pubmed.ncbi.nlm.nih.gov/8667189
Publikováno v:
Journal of medicinal chemistry. 38(18)
Eight analogues of Dyn A(1-11)-NH2 incorporating the enzymatically stable psi(CH2-NH) isosteric peptide bond replacement were synthesized and tested for binding affinity at the central opioid mu, delta, and kappa receptors in guinea pig brain (GPB) h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6af75a62d3a524a8a2e3e84fcee6da3
https://pubmed.ncbi.nlm.nih.gov/7658433
https://pubmed.ncbi.nlm.nih.gov/7658433