Zobrazeno 1 - 10
of 13
pro vyhledávání: '"H I, Roach"'
Publikováno v:
Current Drug Targets. 8:271-282
Osteoarthritis, a degenerative joint disease, is the most disabling condition of the Western world. It affects first and foremost the articular cartilages and leads to a molecular and supramolecular destruction of the extracellular cartilage matrix.
Autor:
X. B. Yang, D. W. Green, H. I. Roach, N. M. P. Clarke, H. C. Anderson, S. M. Howdle, K. M. Shakesheff, R. O. C. Oreffo
Publikováno v:
Connective Tissue Research. 44:312-317
Publikováno v:
The Journal of Bone and Joint Surgery. British volume. :880-887
Chondrocytes of the growth plate are generally assumed to undergo apoptosis, but the mechanisms which induce this cell death are not known. The Fas receptor is a mediator of the apoptotic signal in some systems. We studied its expression in situ in g
Publikováno v:
Cell Biology International. 18:927-936
The relationship between differentiation and concerted cell death was studied using ultrastructural, histochemical and immunochemical methods in solid rat fibrosarcoma Sa-45 grown in the presence of demineralized bone matrix. The control tumour consi
Publikováno v:
Clinical and experimental rheumatology. 24(3)
Collagen fibril degeneration involves initially the cleavage within the triple helix by the collagenases 1 (MMP-1) and 3 (MMP-13), but then mainly involves also the gelatinases A (MMP-2) and B (MMP-9). The objective of this study was to determine the
Publikováno v:
Apoptosis : an international journal on programmed cell death. 9(3)
Evidence has accumulated in recent years that programmed cell death (PCD) is not necessarily synonymous with the classical apoptosis, as defined by Kerr & Wyllie (J Path, 1973, 111:255–261), but that cells use a variety of pathways to undergo cell
Autor:
H I, Roach, N M, Clarke
Publikováno v:
The Journal of bone and joint surgery. British volume. 82(4)
Chondrocytes at the lower zone of the growth plate must be eliminated to facilitate longitudinal growth; this is generally assumed to involve apoptosis. We attempted to provide definitive electron-microscopic evidence of apoptosis in chondrocytes of
Autor:
H I, Roach
Publikováno v:
The Histochemical journal. 31(1)
The activities of acid and alkaline phosphatases were localized by enzyme histochemistry in the chondroepiphyses of 5 week old rabbits. Using paraformaldehyde-lysine-periodate as fixative, the activity of acid phosphatase was particularly well preser
Publikováno v:
The Journal of bone and joint surgery. British volume. 80(5)
Chondrocytes of the growth plate are generally assumed to undergo apoptosis, but the mechanisms which induce this cell death are not known. The Fas receptor is a mediator of the apoptotic signal in some systems. We studied its expression in situ in g